Home › Major Depressive Disorder › Texas
Major Depressive Disorder clinical trials in Texas
37 studies for Major Depressive Disorder are looking for participants at sites in Texas.
Cities in Texas
- Houston16 studies
- Austin13 studies
- Grand Prairie10 studies
- Dallas9 studies
- Wichita Falls6 studies
- Plano5 studies
- Richardson5 studies
- San Antonio5 studies
- Fort Worth4 studies
- Sugar Land3 studies
A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)
- Austin Clinical Trial Partners, Austin
- FutureSearch Trials of Dallas, Dallas
- Revival Research Institute, Llc - McKinney, Tx, McKinney
- and 1 more
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07621237A Study to Evaluate the Efficacy and Safety of Esketamine for Reduction of Symptoms of Major Depressive Disorder
- John S Dunn Behavioral Sciences Center at UTHealth Houston, Houston
RecruitingPhase 3
Ages 12 to 17 · All sexes · Updated Sep 25, 2026 · NCT07227454A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
- Adams Clinical Dallas, DeSoto
- Brain Health Consultants and TMS Center, Houston
- Flourish Research San Antonio, San Antonio
RecruitingPhase 3
Ages 18 to 85 · All sexes · Updated Sep 25, 2026 · NCT06793397Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder
- DM Clinical Research, Houston
- Pillar Clinical Research, LLC, Richardson
RecruitingPhase 3
Ages 18 to 65 · All sexes · Updated Sep 25, 2026 · NCT05850689Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms
- Houston Clinical Trials LLC, Bellaire
- North Texas Clinical Trials, Fort Worth
- Baylor College of Medicine, Houston
- and 1 more
RecruitingPhase 3
Ages 18 to 74 · All sexes · Updated Sep 25, 2026 · NCT06559306Evaluation of Efficacy and Safety of Milsaperidone as Adjunctive Therapy in Patients With Major Depressive Disorder
- Vanda Investigational Site, Houston
- Vanda Investigational Site, Plano
- Vanda Investigational Site, Richardson
- and 1 more
RecruitingPhase 3
Ages 18 to 65 · All sexes · Updated Sep 24, 2026 · NCT06830044A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor
- Neurocrine Clinical Site, Austin
RecruitingPhase 4
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT07105111Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depression
- Wells Medicine, Houston
- Texas A&M (Houston Methodist Hospital Location), Houston
RecruitingPhase 1Healthy volunteers welcome
Ages 21 to 45 · All sexes · Updated Sep 15, 2026 · NCT06480201ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response
- Baylor College of Medicine, Houston
- Olympus Clinical Research, LLC, Katy
- Family Psychiatry of The Woodlands, The Woodlands
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Sep 14, 2026 · NCT07284667A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)
- Seaport Investigator Site, Dallas
- Seaport Investigator Site, Irving
- Seaport Investigator Site, Richardson
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Sep 14, 2026 · NCT07065240A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder (X-NOVA3)
- Austin Clinical Trial Partners, Austin
RecruitingPhase 3
Ages 18 to 74 · All sexes · Updated Sep 8, 2026 · NCT07076407A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression
- Draig Clinical Site, DeSoto
- Draig Clinical Site, Fort Worth
RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Sep 2, 2026 · NCT07610473Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
- University of Texas Austin Dell Medical School, Austin
- University of Texas Southwestern Medical Center at Dallas, Dallas
- CHI St. Luke's Health Baylor College of Medicine Med. Ctr, Houston
- and 1 more
Recruiting
Ages 22 to 70 · All sexes · Updated Aug 28, 2026 · NCT06423430A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression
- Draig Clinical Site, Austin
- Draig Clinical Site, Austin
- Draig Clinical Site, DeSoto
- and 2 more
RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Aug 26, 2026 · NCT07300969Accelerated Intermittent Theta Burst in Treatment-Naive Adolescents
- Dell Medical School at University of Texas at Austin, Austin
Recruiting
Ages 13 to 20 · All sexes · Updated Aug 19, 2026 · NCT06523439NBI-1065845-MDD3025: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
- Neurocrine Clinical Site, DeSoto
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Aug 11, 2026 · NCT06911112A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)
- Austin Clinical Trial Partners, Austin
RecruitingPhase 3
Ages 18 to 74 · All sexes · Updated Aug 10, 2026 · NCT07592689A Study of Brenipatide in Adult Participants With Major Depressive Disorder
- Adams Clinical Dallas, DeSoto
- Re:Cognition Health - Fort Worth, Fort Worth
- Consano Clinical Research, LLC, Shavano Park
RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Aug 6, 2026 · NCT07412756A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder
- Delricht Research - Plano, Plano
- Aim Trials, Llc, Plano
- Grayline Research Center, Wichita Falls
RecruitingPhase 3
Ages 18 to 74 · All sexes · Updated Aug 3, 2026 · NCT06775379Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder
- Austin Clinical Trial Partners, Austin
- InSite Clinical Research, LLC, DeSoto
- Grayline Research Center, Wichita Falls
RecruitingPhase 2
Ages 18 to 64 · All sexes · Updated Aug 3, 2026 · NCT06547489DBS for Depression
- University of Texas Southwestern, Dallas
Recruiting
Ages 22 to 70 · All sexes · Updated Jul 30, 2026 · NCT03437928A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder
- Elevate Synapsis, LLC, Atascocita
- Synapsis Bio, Atascocita
- Adams Clinical Dallas, DeSoto
RecruitingPhase 2
Ages 18 to 64 · All sexes · Updated Jul 27, 2026 · NCT07115329Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol
- Clinical Research Site, Austin
- Clinical Research Site, Bellaire
- Clinical Research Site, Dallas
- and 2 more
RecruitingPhase 3
Ages 18 to 65 · All sexes · Updated Jul 24, 2026 · NCT07484217A Study to Evaluate the Maintenance Effect of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
- Neurocrine Clinical Site, Bellaire
- Neurocrine Clinical Site, Stafford
- Neurocrine Clinical Site, Wichita Falls
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Jul 24, 2026 · NCT07196501Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
- Neurocrine Clinical Site, Bellaire
- Neurocrine Clinical Site, Dallas
- Neurocrine Clinical Site, DeSoto
- and 3 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Jul 24, 2026 · NCT06966401A Study to Assess Change in Disease Activity and Adverse Events of Oral Icalcaprant in Adult Participants With Major Depressive Disorder
- Austin Clinical Trial Partners /ID# 279321, Austin
- Community Clinical Research - Cross Park Drive /ID# 277935, Austin
- Houston Clinical Trials - Bellaire /ID# 277551, Bellaire
- and 1 more
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Jun 15, 2026 · NCT07276997Triage Survey for Psychiatry Research Eligibility
- Adams Clinical, Dallas, DeSoto
RecruitingObservational study
Ages 18 and older · All sexes · Updated May 20, 2026 · NCT05800925A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)
- Biobehavioral Research of Austin, Austin
- InSite Clinical Research, DeSoto
- Aim Trials, LLC, Plano
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated May 11, 2026 · NCT06524830Self Neuro-modulation Therapy for Major Depressive Disorder (MDD) With Anhedonia
- Houston Center For Advanced Psychiatric Treatment, Houston
Recruiting
Ages 22 to 75 · All sexes · Updated May 1, 2026 · NCT06982820Establishing Multimodal Brain Biomarkers for Treatment Selection in Depression
- Health Discovery Building (HDB), 1601 Trinity St., Bldg B., Z0600, Austin
RecruitingPhase 4
Ages 18 to 65 · All sexes · Updated May 1, 2026 · NCT05892744Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services
- University of Texas Southwestern Medical Center, Dallas
RecruitingObservational study
Ages 18 to 40 · All sexes · Updated Mar 10, 2026 · NCT06740383Study of ABX-002 for the Adjunctive Treatment of Major Depressive Disorder (AMPLIFY)
- Autobahn Site #153, Beaumont
- Autobahn Site #146, San Antonio
- Autobahn Site #144, Sherman
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Jan 20, 2026 · NCT06633016Psilocybin rTMS for Treatment Resistant Depression
- Health Discovery Building (HDB), 1601 Trinity St., Bldg B., Z0600, Austin
RecruitingPhase 2
Ages 22 to 65 · All sexes · Updated Nov 26, 2025 · NCT06132178Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
- Neurocrine Clinical Site, Dallas
- Neurocrine Clinical Site, Houston
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 29, 2025 · NCT06786624Study of ALTO-300 in MDD
- Site 347, Fort Worth
- Site 353, Plano
- Site 196, Richmond
RecruitingPhase 2
Ages 18 to 70 · All sexes · Updated Jul 24, 2025 · NCT05922878A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms
- Clinical Research Site, Dallas
- Clinical Research Site, Dallas
- Clinical Research Site, Friendswood
- and 2 more
RecruitingPhase 4
Ages 18 to 65 · All sexes · Updated Jan 23, 2025 · NCT06223880Neurobehavioral Therapy For Epilepsy And Major Depressive Disorder
- Michael E. DeBakey VA Medical Center, Houston
- The University of Texas health Science Center at Houston, Houston
RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Jan 9, 2025 · NCT06695767From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.