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Major Depressive Disorder clinical trials in Austin, TX

13 studies for Major Depressive Disorder are looking for participants at sites in and around Austin (within about 30 miles). Open a study to see who can join and how to contact the study team.

A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 2
  • Austin Clinical Trial Partners, Austin
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07621237

A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder (X-NOVA3)

RecruitingPhase 3
  • Austin Clinical Trial Partners, Austin
Ages 18 to 74 · All sexes · Updated Sep 8, 2026 · NCT07076407

Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)

Recruiting
  • University of Texas Austin Dell Medical School, Austin
Ages 22 to 70 · All sexes · Updated Aug 28, 2026 · NCT06423430

A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression

RecruitingPhase 2
  • Draig Clinical Site, Austin
  • Draig Clinical Site, Austin
Ages 18 to 75 · All sexes · Updated Aug 26, 2026 · NCT07300969

Accelerated Intermittent Theta Burst in Treatment-Naive Adolescents

Recruiting
  • Dell Medical School at University of Texas at Austin, Austin
Ages 13 to 20 · All sexes · Updated Aug 19, 2026 · NCT06523439

A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)

RecruitingPhase 3
  • Austin Clinical Trial Partners, Austin
Ages 18 to 74 · All sexes · Updated Aug 10, 2026 · NCT07592689

Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder

RecruitingPhase 2
  • Austin Clinical Trial Partners, Austin
Ages 18 to 64 · All sexes · Updated Aug 3, 2026 · NCT06547489

Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol

RecruitingPhase 3
  • Clinical Research Site, Austin
Ages 18 to 65 · All sexes · Updated Jul 24, 2026 · NCT07484217

A Study to Assess Change in Disease Activity and Adverse Events of Oral Icalcaprant in Adult Participants With Major Depressive Disorder

RecruitingPhase 2
  • Austin Clinical Trial Partners /ID# 279321, Austin
  • Community Clinical Research - Cross Park Drive /ID# 277935, Austin
Ages 18 to 65 · All sexes · Updated Jun 15, 2026 · NCT07276997

A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)

RecruitingPhase 2
  • Biobehavioral Research of Austin, Austin
Ages 18 to 65 · All sexes · Updated May 11, 2026 · NCT06524830

Establishing Multimodal Brain Biomarkers for Treatment Selection in Depression

RecruitingPhase 4
  • Health Discovery Building (HDB), 1601 Trinity St., Bldg B., Z0600, Austin
Ages 18 to 65 · All sexes · Updated May 1, 2026 · NCT05892744

Psilocybin rTMS for Treatment Resistant Depression

RecruitingPhase 2
  • Health Discovery Building (HDB), 1601 Trinity St., Bldg B., Z0600, Austin
Ages 22 to 65 · All sexes · Updated Nov 26, 2025 · NCT06132178

Major Depressive Disorder trials in other cities

Other studies in Austin

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.