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Major Depressive Disorder clinical trials in Houston, TX
21 studies for Major Depressive Disorder are looking for participants at sites in and around Houston (within about 30 miles). Open a study to see who can join and how to contact the study team.
Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
RecruitingPhase 3
- Brain Health Consultants and TMS Center, Houston
Regulated Stimulation for Optimized Network Activity and Therapeutic Equilibrium
Recruiting
- UTHealth Houston, Houston
- Brain Health Consultants and TMS Center, Houston
ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response
RecruitingPhase 2
- Baylor College of Medicine, Houston
Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms
RecruitingPhase 3
- Baylor College of Medicine, Houston
- Houston Clinical Trials LLC, Bellaire · 7 mi away
A Study to Evaluate the Efficacy and Safety of Esketamine for Reduction of Symptoms of Major Depressive Disorder
RecruitingPhase 3
- John S Dunn Behavioral Sciences Center at UTHealth Houston, Houston
Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder
RecruitingPhase 3
- DM Clinical Research, Houston
A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder
RecruitingPhase 3
- Baylor College of Medicine, Houston
- DM Clinical Research, Houston
Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
RecruitingPhase 3
- Neurocrine Clinical Site, Houston
Double-blind, Placebo-controlled Study in Adults With Major Depressive Disorder
RecruitingPhase 2
- Baylor College of Medicine, Houston
- DM Clinical, Houston
- Houston Clinical Trials, Bellaire · 7 mi away
Study of ALTO-300 in MDD
RecruitingPhase 2
- Site 275, Houston
- Site 320, Houston
A Study to Evaluate the Maintenance Effect of Osavampator as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
RecruitingPhase 3
- Neurocrine Clinical Site, Bellaire · 7 mi away
Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
Recruiting
- CHI St. Luke's Health Baylor College of Medicine Med. Ctr, Houston
- The Methodist Hospital, Houston
Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol
RecruitingPhase 3
- Clinical Research Site, Houston
- Clinical Research Site, Bellaire · 7 mi away
Cortical rTMS as a Treatment for Depression
Recruiting
- The Menninger Clinic, Houston
Evaluation of Efficacy and Safety of Milsaperidone as Adjunctive Therapy in Patients With Major Depressive Disorder
RecruitingPhase 3
- Vanda Investigational Site, Houston
Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depression
RecruitingPhase 1Healthy volunteers welcome
- Wells Medicine, Houston
- Texas A&M (Houston Methodist Hospital Location), Houston
A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder
RecruitingPhase 2
- Elevate Synapsis, LLC, Atascocita · 20 mi away
- Synapsis Bio, Atascocita · 20 mi away
A Study to Assess Change in Disease Activity and Adverse Events of Oral Icalcaprant in Adult Participants With Major Depressive Disorder
RecruitingPhase 2
- Houston Clinical Trials - Bellaire /ID# 277551, Bellaire · 7 mi away
Self Neuro-modulation Therapy for Major Depressive Disorder (MDD) With Anhedonia
Recruiting
- Houston Center For Advanced Psychiatric Treatment, Houston
Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
RecruitingPhase 3
- Neurocrine Clinical Site, Houston
Neurobehavioral Therapy For Epilepsy And Major Depressive Disorder
RecruitingHealthy volunteers welcome
- Michael E. DeBakey VA Medical Center, Houston
- The University of Texas health Science Center at Houston, Houston
Major Depressive Disorder trials in other cities
- New York City, NY34 studies
- Boston, MA31 studies
- Atlanta, GA24 studies
- Philadelphia, PA20 studies
- Orlando, FL18 studies
- Miami, FL17 studies
- Tampa, FL17 studies
- Chicago, IL15 studies
- San Diego, CA14 studies
- Orange, CA13 studies
- Las Vegas, NV13 studies
- Austin, TX13 studies
Other studies in Houston
- Non-Small Cell Lung Cancer143 studies
- Breast Cancer126 studies
- Cancer (all types)124 studies
- Colorectal Cancer101 studies
- Metastatic Cancer100 studies
- Ovarian Cancer90 studies
- Acute Myeloid Leukemia88 studies
- Lung Cancer78 studies
- Prostate Cancer73 studies
- Endometrial Cancer69 studies
- Melanoma61 studies
- Pancreatic Cancer59 studies
From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.