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Osteoarthritis clinical trials in Chicago, IL

9 studies for Osteoarthritis are looking for participants at sites in and around Chicago (within about 30 miles). Open a study to see who can join and how to contact the study team.

A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee

RecruitingPhase 3
  • Northwestern University, Chicago
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07153471

Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight

RecruitingPhase 3
  • Great Lakes Clinical Trials - Ravenswood, Chicago
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07353931

Phase 3 Pivotal Trial Comparing CARTISTEM® and Surgical Comparator for Knee Cartilage Lesions and Osteoarthritis

RecruitingPhase 3
  • Rush University Medical Center, Chicago
Ages 18 to 75 · All sexes · Updated Sep 17, 2026 · NCT07339111

Patient Pain and Function in Medial Knee Osteoarthritis After Anteromedial vs Anterolateral Intra-Articular Corticosteroid Injection

Recruiting
  • Hyde Park Clinic, Chicago
Ages 40 and older · All sexes · Updated Sep 4, 2026 · NCT07804446

A Study to Assess Safety and Tolerability of PCRX-201 in Subjects With Painful Osteoarthritis of the Knee

RecruitingPhase 2
  • Rush Medical College - Division of Rheumatology, Chicago
Ages 45 to 80 · All sexes · Updated Aug 25, 2026 · NCT06884865

Genicular Artery Embolization for Knee Osteoarthritis

Recruiting
  • Northwestern University, Chicago
Ages 40 to 80 · All sexes · Updated Jul 14, 2026 · NCT07537153

Brain-Based and Clinical Phenotyping of Pain Pharmacotherapy in Knee Osteoarthritis

RecruitingPhase 4
  • Northwestern University, Chicago
Ages 41 and older · All sexes · Updated Apr 30, 2026 · NCT06245109

A Study to Evaluate the Efficacy and Safey of PTP-001 (MOTYS™) in Knee Osteoarthritis Patients

RecruitingPhase 3
  • Chicago Clinical Research Institute, Inc., Chicago
Ages 40 to 80 · All sexes · Updated Apr 29, 2026 · NCT07219771

Genicular Artery Embolization for Reducing Pain in Medically Refractory Symptomatic Knee Osteoarthritis

RecruitingPhase 2
  • University of Chicago, Chicago
Ages 40 to 80 · All sexes · Updated May 15, 2025 · NCT06859164

About Osteoarthritis

Osteoarthritis is the most common form of arthritis. It usually affects your hands, knees, hips, or spine. Learn about treatment and management.

More about Osteoarthritis on MedlinePlus

Osteoarthritis trials in other cities

Other studies in Chicago

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.