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Osteoarthritis clinical trials in Chicago, IL

8 studies for Osteoarthritis are looking for participants at sites in and around Chicago (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

A Study to Learn About Study Medicine Called Berobenatide in Adults With Knee Pain and Overweight or Obesity (VESPER-OA 1)

RecruitingPhase 3
  • Northwestern Medicine, Chicago
  • Northwestern Memorial Hospital, Diagnostic Testing Center (Phlebotomy/EKG), Chicago
  • Northwestern Memorial Hospital, Investigational Drug Service, Chicago
  • and 2 more
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT07919678

Phase 3 Pivotal Trial Comparing CARTISTEM® and Surgical Comparator for Knee Cartilage Lesions and Osteoarthritis

RecruitingPhase 3
  • Rush University Medical Center, Chicago
Ages 18 to 75 · All sexes · Updated Nov 5, 2026 · NCT07339111

Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight

RecruitingPhase 3
  • Great Lakes Clinical Trials - Ravenswood, Chicago
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07353931

A Study to Evaluate the Efficacy and Safey of PTP-001 (MOTYS™) in Knee Osteoarthritis Patients (MOTION-P)

RecruitingPhase 3
  • Chicago Clinical Research Institute, Inc., Chicago
Ages 40 to 80 · All sexes · Updated Oct 16, 2026 · NCT07219771

Patient Pain and Function in Medial Knee Osteoarthritis After Anteromedial vs Anterolateral Intra-Articular Corticosteroid Injection

Recruiting
  • Hyde Park Clinic, Chicago
Ages 40 and older · All sexes · Updated Sep 4, 2026 · NCT07804446

A Study to Assess Safety and Tolerability of PCRX-201 in Subjects With Painful Osteoarthritis of the Knee

RecruitingPhase 2
  • Rush Medical College - Division of Rheumatology, Chicago
Ages 45 to 80 · All sexes · Updated Aug 25, 2026 · NCT06884865

Genicular Artery Embolization for Knee Osteoarthritis

Recruiting
  • Northwestern University, Chicago
Ages 40 to 80 · All sexes · Updated Jul 14, 2026 · NCT07537153

Brain-Based and Clinical Phenotyping of Pain Pharmacotherapy in Knee Osteoarthritis

RecruitingPhase 4
  • Northwestern University, Chicago
Ages 41 and older · All sexes · Updated Apr 30, 2026 · NCT06245109

About Osteoarthritis

Osteoarthritis is the most common form of arthritis. It usually affects your hands, knees, hips, or spine. Learn about treatment and management.

More about Osteoarthritis on MedlinePlus

Osteoarthritis trials in other cities

Other studies in Chicago

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.