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Patient Pain and Function in Medial Knee Osteoarthritis After Anteromedial vs Anterolateral Intra-Articular Corticosteroid Injection
Does Injection Site (Anteromedial vs Anterolateral) Affect Pain Relief After Intra-Articular Corticosteroid Injection in Moderate-to-Severe Medial Knee Osteoarthritis?
Who can join
Ages 40 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * Age ≥ 40 * Clinical diagnosis of knee OA with predominant medial compartment symptoms * Radiographic moderate-to-severe medial compartment OA (KL grade 3-4 or equivalent) * Agreed to and preparing to receive a CSI of the knee as part of standard care from surgeon, regardless of past injection of the knee * Able to provide informed consent * Able to complete phone, email, or MyChart follow-ups in English Exclusion Criteria: * Predominant lateral compartment OA or patellofemoral-only OA * Inflammatory arthritis (RA, gout flare, etc.) * Suspected or confirmed joint infection or overlying cellulitis * Prior knee arthroplasty on the index knee * Planned surgery for index knee within 12-week follow-up * Inability to complete follow-up assessments * Other clinician-determined contraindication to CSI
About the study
The primary purpose of this study is to find out if there is a difference in pain experienced in patients with knee arthritis of the inside of their knee if they get a steroid injection on the inside or outside of their knee. Participants will:
1. Be randomly divided into getting their steroid injection on the inside or outside of their knee. 2. Answer a pain survey before their injection as well as over the phone 2 weeks, 6 weeks, and 12 weeks after their injection.
What is being tested
- Anteromedial Injection (procedure)
- Anterolateral Injection (procedure)
Sponsor: University of Chicago · Participants: 140 · Started: Aug 31, 2026
Contact the study team
- Malik J Scott, B.A. · Phone: 773-834-3531
Official record on ClinicalTrials.gov — NCT07804446
Locations in the U.S.
| Illinois | Bolingbrook Clinic, Bolingbrook Hyde Park Clinic, Chicago La Grange Clinic, La Grange Orland Park Clinic, Orland Park Woodridge Clinic, Woodridge |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.