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Schizophrenia clinical trials in Chicago, IL

20 studies for Schizophrenia are looking for participants at sites in and around Chicago (within about 30 miles). Open a study to see who can join and how to contact the study team.

Relapse Prevention Trial Evaluating KarXT Treatment in Schizophrenia

RecruitingPhase 3
  • Local Institution - 0067, Chicago
  • Pillar Clinical Research -Chicago, Chicago
Ages 18 to 65 · All sexes · Updated Sep 28, 2026 · NCT07686263

A Study of the Feasibility, Safety and Tolerability of Aticaprant as Adjunctive Treatment in Participants With Schizophrenia

RecruitingPhase 1
  • Uptown Research Institute, Chicago
Ages 18 to 55 · All sexes · Updated Sep 28, 2026 · NCT07615426

NBI-1117568-SCZ3032: Long-Term Evaluation of NBI-1117568 in Adults With Schizophrenia

RecruitingPhase 3
  • Neurocrine Clinical Site, Chicago
Ages 18 to 65 · All sexes · Updated Sep 25, 2026 · NCT07114874

A Study of Brenipatide in Adult Participants With Schizophrenia

RecruitingPhase 2
  • Re:Cognition Health - Chicago, Chicago
Ages 18 to 55 · All sexes · Updated Sep 22, 2026 · NCT07410507

A Study to Evaluate the Long-term Safety and Tolerability of Xanomeline and Trospium Chloride for the Treatment of Psychiatric Disorders in Children and Adolescents

RecruitingPhase 3
  • Local Institution - 0175, Chicago
  • EmVenio Research Center - Prime Healthcare, Chicago
Ages 5 to 17 · All sexes · Updated Sep 22, 2026 · NCT07424404

52-week Open Label Safety-Tolerability Study

RecruitingPhase 3
  • Pillar Clinical Research, Chicago
Ages 18 to 65 · All sexes · Updated Sep 9, 2026 · NCT07369154

A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Schizophrenia in Adolescents (EMERGENT TEEN)

RecruitingPhase 3
  • Local Institution - 0122, Chicago
  • EmVenio Research Center - Prime Healthcare, Chicago
Ages 13 to 17 · All sexes · Updated Sep 4, 2026 · NCT07288567

A Study to Evaluate the Safety, Tolerability, and PK of an Injectable Form of KarXT

RecruitingPhase 1
  • Uptown Research Institute, Chicago
Ages 18 to 55 · All sexes · Updated Sep 2, 2026 · NCT07061288

A Long-Term Open-Label Study of ML-007C-MA in Adults With Schizophrenia

RecruitingPhase 2
  • Clinical Site, Chicago
Ages 18 to 65 · All sexes · Updated Sep 1, 2026 · NCT07459647

Study to Evaluate Weight Gain as Assessed by Change in BMI Z-score in Pediatric Subjects With Schizophrenia or Bipolar I Disorder

RecruitingPhase 3
  • Alkermes Investigator Site, Chicago
Ages 10 to 17 · All sexes · Updated Aug 14, 2026 · NCT05303064

Study to Assess the Safety, Tolerability, and Treatment Response of GXV813 in Hospitalized Adults With Schizophrenia

RecruitingPhase 2
  • Uptown Research Institute LLC, Chicago
  • Pillar Clinical Research LLC, Chicago
Ages 18 to 65 · All sexes · Updated Jul 29, 2026 · NCT07467993

Study to Evaluate LB-102 for the Treatment of Adult Patients With Acute Schizophrenia

RecruitingPhase 3
  • Pillar Clinical Research, Chicago
Ages 18 to 65 · All sexes · Updated Jul 27, 2026 · NCT07363577

A Study to Evaluate KYN-5356 in Adults With Cognitive Impairment Associated With Schizophrenia

RecruitingPhase 2
  • Uptown Research Institute, Chicago
Ages 18 to 55 · All sexes · Updated Jun 23, 2026 · NCT07191483

A Study to Evaluate the Effect of KarXT on Urological Safety

RecruitingPhase 4
  • Uptown Research Institute, Chicago
  • Pillar Clinical Research -Chicago, Chicago
Ages 18 to 65 · All sexes · Updated Jun 3, 2026 · NCT07221877

CLOZAPINE Response in Biotype-1

RecruitingPhase 4
  • University of Chicago, Chicago
Ages 18 to 60 · All sexes · Updated May 11, 2026 · NCT04580134

Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services

RecruitingObservational study
  • University of Chicago Medical Center, Chicago
Ages 18 to 40 · All sexes · Updated Mar 10, 2026 · NCT06740383

NBI-1117568-SCZ3029: Evaluation of NBI-1117568 in Inpatient Adults With Schizophrenia

RecruitingPhase 3
  • Neurocrine Clinical Site, Chicago
Ages 18 to 65 · All sexes · Updated Mar 6, 2026 · NCT06963034

Randomized Withdrawal Study in Patients With Schizophrenia

RecruitingPhase 3
  • Vanda Investigational Site, Chicago
Ages 18 to 65 · All sexes · Updated Jan 12, 2026 · NCT06961968

Study of ALTO-101 in Patients With Schizophrenia

RecruitingPhase 2
  • Site 5056, Chicago
Ages 21 to 55 · All sexes · Updated Dec 26, 2025 · NCT06502964

Safety and Efficacy of Brilaroxazine (RP5063) in Schizophrenia

RecruitingPhase 3Healthy volunteers welcome
  • Reviva site, Chicago
Ages 18 to 65 · All sexes · Updated Dec 19, 2024 · NCT05184335

About Schizophrenia

Schizophrenia is a serious brain illness that can include hearing voices that aren't there and thinking others are trying to hurt them.

More about Schizophrenia on MedlinePlus

Schizophrenia trials in other cities

Other studies in Chicago

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.