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Stroke clinical trials in Chicago, IL

35 studies for Stroke are looking for participants at sites in and around Chicago (within about 30 miles). Open a study to see who can join and how to contact the study team.

Self-Directed Upper Extremity Gaming in Inpatients With Stroke

Recruiting
  • Shirley Ryan AbilityLab, Chicago
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT07806097

An Open Label Extension (OLE) Study (Following Completion of CTQJ230A12301) to Evaluate Long-term Safety and Tolerability of Pelacarsen (TQJ230)

RecruitingPhase 3
  • Rush University Medical Center, Chicago
Ages 18 to 100 · All sexes · Updated Sep 4, 2026 · NCT07517263

Treatment With Endovascular Intervention for STroke Patients With Existing Disability

RecruitingObservational study
  • University of Chicago, Chicago
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT05911568

Effect of Neural Constraints on Movement in Stroke

RecruitingEarly phase 1Healthy volunteers welcome
  • Northwestern University, Dept. of PTHMS 645 N Michigan Ave, Suite 1100, Chicago
Ages 18 to 80 · All sexes · Updated Aug 18, 2026 · NCT06666673

Movement Amplification Gait Training to Enhance Walking Balance Post-Stroke

Recruiting
  • Northwestern University, Chicago
Ages 18 to 80 · All sexes · Updated Aug 14, 2026 · NCT06400186

Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis- Magnetic Resonance Imaging

RecruitingObservational study
  • University of Illinois Hospital, Chicago
  • University of Chicago Medical Center, Chicago
Ages 18 and older · All sexes · Updated Jul 16, 2026 · NCT05907629

Alternative Therapies for Improving Physical Function in Individuals With Stroke

RecruitingHealthy volunteers welcome
  • University of Illinois at Chicago, Chicago
Ages 18 to 90 · All sexes · Updated Jul 8, 2026 · NCT03869138

The REACTplusNMES Trial: A Double-blinded RCT

Recruiting
  • University of Illinois at Chicago, Chicago
Ages 18 to 90 · All sexes · Updated Jul 7, 2026 · NCT06127602

Reactive Balance Training for Fall Prevention

RecruitingHealthy volunteers welcome
  • University of Illinois at Chicago, Chicago
Ages 18 to 90 · All sexes · Updated Jul 6, 2026 · NCT04205279

Genetic and Environmental Risk Factors for Hemorrhagic Stroke

RecruitingObservational studyHealthy volunteers welcome
  • University of Illinois Chicago, Chicago
Ages 18 and older · All sexes · Updated Jul 2, 2026 · NCT00682695

The Pivotal Study of RapidPulseTM Aspiration System

Recruiting
  • Rush University Medical Center, Chicago
Ages 18 to 80 · All sexes · Updated Jul 2, 2026 · NCT06029491

Tele-CE in Severe Stroke

Recruiting
  • Brain Plasticity Lab, Chicago
Ages 18 to 80 · All sexes · Updated Jun 17, 2026 · NCT07652970

MINT Conditioning to Improve Gait

Recruiting
  • Northwestern University, Chicago
Ages 18 to 85 · All sexes · Updated Jun 8, 2026 · NCT07041775

Combining MyoCI With Memory Reactivation to Improve Motor Recovery After Stroke

Recruiting
  • Northwestern University, Chicago
Ages 21 to 100 · All sexes · Updated May 27, 2026 · NCT04312269

Hospital Implementation of a Stroke Protocol for Emergency Evaluation and Disposition

Recruiting
  • UChicago Medicine Ingalls Memorial Hospital, Chicago
Ages 18 and older · All sexes · Updated May 20, 2026 · NCT06094478

Nomad P-KAFO Study

Recruiting
  • Shirley Ryan AbilityLab, Chicago
Ages 18 to 89 · All sexes · Updated May 11, 2026 · NCT05644522

Characterization and Clinical Trial of a Variable Friction Shoe

Recruiting
  • Shirley Ryan AbilityLab, Chicago
Ages 18 and older · All sexes · Updated May 11, 2026 · NCT06234124

Cortical Priming to Optimize Gait Rehabilitation in Stroke: a Renewal

Recruiting
  • Physical Therapy, Chicago
Ages 18 and older · All sexes · Updated May 11, 2026 · NCT04477330

Wearable MCI to Reduce Muscle Co-activation in Acute and Chronic Stroke

Recruiting
  • Northwestern University, Chicago
Ages 21 and older · All sexes · Updated Apr 8, 2026 · NCT03401762

Low Dose ColchicinE in pAtients With Peripheral Artery DiseasE to Address Residual Vascular Risk

RecruitingPhase 3
  • University of Chicago Medical Center, Chicago
Ages 18 and older · All sexes · Updated Mar 24, 2026 · NCT04774159

Locomotor Function Following Transcutaneous Electrical Spinal Cord Stimulation in Individuals With Hemiplegic Stroke

Recruiting
  • Shirley Ryan AbilityLab, Chicago
Ages 18 and older · All sexes · Updated Mar 17, 2026 · NCT05167786

Inpatient Stroke Recovery Using Sensors

RecruitingObservational studyHealthy volunteers welcome
  • Shirley Ryan AbilityLab, Chicago
Ages 18 and older · All sexes · Updated Dec 29, 2025 · NCT04219670

Stroke Thrombectomy and Aneurysm Registry

RecruitingObservational study
  • Rush University, Chicago
  • University of Chicago, Chicago
  • University of Illinois, Chicago
Ages 1 to 120 · All sexes · Updated Dec 24, 2025 · NCT04994756

Proximal Internal Carotid Artery Acute Stroke Secondary to Tandem or Local Occlusion Thrombectomy Trial

RecruitingPhase 3
  • Ascension/Alexian Brothers Health System, Chicago
  • University of Chicago, Chicago
Ages 18 to 79 · All sexes · Updated Dec 17, 2025 · NCT05611242

Human/Machine Interface: What the HeartMate 3 ® Device Tells Us About the Future

RecruitingObservational study
  • University of Chicago, Chicago
Ages 18 to 100 · All sexes · Updated Dec 16, 2025 · NCT06039176

Mapping Corticoreticulospinal Motor Control in Chronic Hemiparetic Stroke

RecruitingHealthy volunteers welcome
  • Northwestern University, Chicago
Ages 18 and older · All sexes · Updated Oct 1, 2025 · NCT06598150

WIM Exosuit Wearable Soft Robot for Enhancing Walking Activity

RecruitingHealthy volunteers welcome
  • Shirley Ryan AbilityLab, Chicago
Ages 18 to 89 · All sexes · Updated Aug 29, 2025 · NCT07061691

Transcutaneous Electrical Stimulation for Stroke Patients

Recruiting
  • Shirley Ryan AbilityLab, Chicago
Ages 18 and older · All sexes · Updated Aug 12, 2025 · NCT06950593

Constraint Induced Movement Therapy for Walking in Individuals Post Stroke

Recruiting
  • Abilitylab, Chicago
Ages 21 to 75 · All sexes · Updated Jun 3, 2025 · NCT03264261

R01.Aim 2.Study 1: IsoReach

RecruitingEarly phase 1Healthy volunteers welcome
  • Shirley Ryan AbilityLab, Chicago
Ages 18 and older · All sexes · Updated Jan 9, 2025 · NCT06656754

Safety and Feasibility of an ExoNET for Supination Assistance for Stroke Survivors

RecruitingHealthy volunteers welcome
  • Shirley Ryan AbilityLab, Chicago
Ages 40 to 70 · All sexes · Updated Jan 9, 2025 · NCT06655636

Error-enhanced Learning & Recovery in 2 & 3 Dimensions

RecruitingHealthy volunteers welcome
  • Shirley Ryan AbilityLab (Healthy Participants), Chicago
  • Shirley Ryan AbilityLab, Chicago
  • Shirley Ryan AbilityLab, Chicago
Ages 18 and older · All sexes · Updated Oct 24, 2024 · NCT05180786

MANAGE-VT Registry - MANAGEment of Ventricular Tachycardia Outcomes Registry

RecruitingObservational studyHealthy volunteers welcome
  • Corvita Science Foundation, Chicago
Ages 18 and older · All sexes · Updated Jun 12, 2024 · NCT06455488

MANAGE-AF Registry -MANAGEment of Atrial Fibrillation Outcomes Registry (MANAGE-AF)

RecruitingObservational study
  • CorVita Science Foundation (NFP), Chicago
Ages 18 and older · All sexes · Updated Jan 18, 2024 · NCT05978466

About Stroke

A stroke happens when there is a loss of blood flow to part of the brain. Immediate treatment may save a life and increase the chances for successful recovery.

More about Stroke on MedlinePlus

Stroke trials in other cities

Other studies in Chicago

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.