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Obesity clinical trials in Chicago, IL

40 studies for Obesity are looking for participants at sites in and around Chicago (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Scalable TELeheaLth Cancer CARe: The STELLAR Program to Treat Cancer Risk Behaviors

Recruiting
  • Northwestern University-Feinberg School of Medicine, Chicago
Ages 18 and older · All sexes · Updated Nov 6, 2026 · NCT05687604

Study of Olatorepatide in Adult Participants Living With Overweight or Obesity Without Diabetes

RecruitingPhase 2
  • Charter Research LLC - Chicago, Chicago
  • Flourish Research, Ravenswood Rheumatology, Chicago
Ages 18 and older · All sexes · Updated Nov 6, 2026 · NCT07685808

A Study to Learn About Study Medicine Called Berobenatide in Adults With Knee Pain and Overweight or Obesity (VESPER-OA 1)

RecruitingPhase 3
  • Northwestern Medicine, Chicago
  • Northwestern Memorial Hospital, Diagnostic Testing Center (Phlebotomy/EKG), Chicago
  • Northwestern Memorial Hospital, Investigational Drug Service, Chicago
  • and 2 more
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT07919678

A Study to Learn About the Study Medicine Called Berobenatide (PF-08653944) in People With Overweight or Obesity

RecruitingPhase 3
  • Cedar Crosse Research Center, Chicago
  • Northwestern University, Chicago
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT07595549

Efficacy, Safety, and Pharmacokinetics of Tirzepatide (LY3298176) Once Weekly Versus Placebo in Pediatric Participants 6 to Less Than 12 Years of Age Who Have Obesity (ADVANCE-SURMOUNT-KIDS)

RecruitingPhase 3
  • Ann and Robert H Lurie Children's Hospital of Chicago, Chicago
  • University of Illinois at Chicago, Chicago
Ages 6 to 11 · All sexes · Updated Nov 4, 2026 · NCT07817875

A Study of Eloralintide (LY3841136) in Participants With Persistent Obesity Who Are Treated With a Weekly Incretin

RecruitingPhase 3
  • Great Lakes Clinical Trials - Ravenswood, Chicago
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07392190

Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight

RecruitingPhase 3
  • Great Lakes Clinical Trials - Ravenswood, Chicago
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07353931

Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or Overweight

RecruitingPhase 3
  • Rush University Medical Center, Chicago
Ages 18 to 70 · All sexes · Updated Nov 4, 2026 · NCT06937099

Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study

RecruitingPhase 3
  • Rush University Medical Center, Chicago
Ages 18 to 70 · All sexes · Updated Nov 4, 2026 · NCT06937086

A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)

RecruitingPhase 3
  • Ann and Robert Lurie Children's Hospital of Chicago, Chicago
  • University of Illinois at Chicago, Chicago
Ages 6 to 17 · All sexes · Updated Nov 4, 2026 · NCT06672549

A Study to Evaluate Effect of AZD6234 in Adult Participants With Obesity or Overweight With Weight-related Comorbidity Without Type 2 Diabetes Mellitus

RecruitingPhase 3
  • Research Site, Chicago
Ages 18 and older · All sexes · Updated Oct 30, 2026 · NCT07784725

A Study to Evaluate Effect of AZD6234 in Adult Participants With Type 2 Diabetes Mellitus and Obesity or Overweight

RecruitingPhase 3
  • Research Site, Chicago
Ages 18 and older · All sexes · Updated Oct 28, 2026 · NCT07784270

Safety and Efficacy of ABBV-295 in Adults With Obesity or Overweight With Weight-Related Comorbidities

RecruitingPhase 2
  • Great Lakes Clinical Trials - West Wilson Avenue /ID# 282378, Chicago
Ages 18 to 75 · All sexes · Updated Oct 27, 2026 · NCT07752979

A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight

RecruitingPhase 2
  • Great Lakes Clinical Trials - Ravenswood, Chicago
Ages 18 to 75 · All sexes · Updated Oct 8, 2026 · NCT07589608

A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight

RecruitingPhase 2
  • Great Lakes Clinical Trials - Ravenswood, Chicago
Ages 18 to 75 · All sexes · Updated Oct 7, 2026 · NCT06143956

Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide (MARITIME-1-EXTENSION)

RecruitingPhase 3
  • Flourish Research - Great Lakes Clinical Trials, Chicago
Ages 18 to 99 · All sexes · Updated Oct 5, 2026 · NCT07684235

A Trial to Examine the Effects of a Weight Loss Program Emphasizing Protein, Dietary Fiber, and Exercise (30-30-30 Plan)

RecruitingHealthy volunteers welcome
  • Illinois Institute of Technology, Chicago
Ages 18 to 69 · All sexes · Updated Oct 5, 2026 · NCT07789769

AMAZE 9: A Research Study Investigating How Well Zenagamtide Tablets Help People With Excess Body Weight Lose Weight

RecruitingPhase 3
  • Great Lakes Clinical Trials, Chicago
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07720271

A Research Study Investigating How Well the Medicine Zenagamtide Helps People With Excess Body Weight Lose Weight Compared to Semaglutide

RecruitingPhase 3
  • Chicago Research Center, Inc, Chicago
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07668414

BRIDGE & Friends Trial

RecruitingHealthy volunteers welcome
  • University of Illinois Chicago, Chicago
Ages 50 to 79 · All sexes · Updated Sep 1, 2026 · NCT07798557

Assess the Effects of Replacing Foods High in Refined Carbohydrates With Avocado on Biomarkers of Inflammation.

RecruitingHealthy volunteers welcome
  • Illinois Institute of Technology, Chicago
Ages 21 to 74 · All sexes · Updated Aug 27, 2026 · NCT07566325

Caloric Restriction and Activity to Reduce Chemoresistance in B-ALL

RecruitingPhase 2
  • Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago
Ages 7 to 25 · All sexes · Updated Aug 19, 2026 · NCT05082519

Digital InteGrated Behavioral treatmeNt for Comorbid obesITy and deprEssion Among Racial and Ethnic Adults Age 50 and Older

Recruiting
  • Department of Medicine, Vitoux Program on Aging and Prevention, Chicago
Ages 50 to 74 · All sexes · Updated Aug 18, 2026 · NCT06636058

A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity

RecruitingPhase 3
  • Chicago Clinical Research Institute INC, Chicago
  • Univer Of Illinois at Chicago, Chicago
  • Eagle Clinical Research, Chicago
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT07567001

Role of Adiposomes in Endothelial Dysfunction

Recruiting
  • University of Illinois at Chicago, Chicago
Ages 18 to 50 · All sexes · Updated Aug 17, 2026 · NCT05199454

Efficacy and Safety of Aleniglipron in Participants With Obesity or Overweight With a Weight-Related Comorbidity (ACCOMPLISH-1)

RecruitingPhase 3
  • ACCOMPLISH-1 Research Site, Chicago
Ages 18 to 79 · All sexes · Updated Aug 10, 2026 · NCT07654361

Functional Improvement in OSA and COPD With a Telehealth LifeStyle and Exercise Intervention

Recruiting
  • Jesse Brown VA Medical Center, Chicago
Ages 18 and older · All sexes · Updated Jul 22, 2026 · NCT06390345

FIM+DASH: Food is Medicine Intervention to Promote Healthy Eating and Blood Pressure Control

RecruitingPhase 2
  • Mile Square Health Center Chicago, Chicago
  • Mile Square Health Center - Auburn Gresham, Chicago
  • Mile Square Health Center - Englewood, Chicago
  • and 1 more
All ages · All sexes · Updated Jul 10, 2026 · NCT07332741

Better Lifestyle Counseling for African American Women During Pregnancy

Recruiting
  • University of Illinois at Chicago, Chicago
  • University of Illinois at Chicago, Chicago
Ages 18 to 40 · Women · Updated Jul 9, 2026 · NCT05234125

PRImary Care Strategies for Weight Management (PRISM) Study

Recruiting
  • Rush University Medical Center, Chicago
Ages 18 and older · All sexes · Updated Jul 9, 2026 · NCT07288294

Conical Forearm and Cylindrical Upper Arm Non-Invasive Blood Pressure (NIBP) Measurements in Pregnant Patients

Recruiting
  • Prentice Women's Hospital, Chicago
Ages 18 and older · Women · Updated May 26, 2026 · NCT06466161

EAT: A Reliable Eating Assessment Technology for Free-living Individuals

RecruitingHealthy volunteers welcome
  • Northwestern University, Chicago
Ages 18 and older · All sexes · Updated May 7, 2026 · NCT06118528

RemI for Post-Bariatric Surgery Weight Regain

RecruitingHealthy volunteers welcome
  • Rush University, Chicago
Ages 18 to 70 · All sexes · Updated Apr 3, 2026 · NCT06292936

People With Multiple Sclerosis Treated With Ocrelizumab and GLP-1 Agonists

RecruitingObservational study
  • Northwestern Memorial Hospital, Chicago
Ages 18 to 70 · All sexes · Updated Mar 17, 2026 · NCT07207148

Predictors of Behavioral Obesity Treatment Outcomes

RecruitingHealthy volunteers welcome
  • Rush University Medical Center, Chicago
Ages 18 and older · All sexes · Updated Mar 11, 2026 · NCT05326477

Semaglutide for Metabolic Intervention and Adipose Loss to Treat Atrial Fibrillation

RecruitingPhase 3
  • University of Chicago, Chicago
Ages 18 to 75 · All sexes · Updated Nov 14, 2025 · NCT06499857

DNA Methylation and Vascular Function

RecruitingHealthy volunteers welcome
  • University of Illinois at Chicago, Chicago
Ages 18 to 50 · All sexes · Updated Sep 15, 2025 · NCT03527420

About Obesity

Read about the causes of obesity and find out what you can do to decrease your risk of its associated health issues.

More about Obesity on MedlinePlus

Obesity trials in other cities

Other studies in Chicago

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.