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Overweight clinical trials in Chicago, IL

27 studies for Overweight are looking for participants at sites in and around Chicago (within about 30 miles). Open a study to see who can join and how to contact the study team.

A Research Study Investigating How Well the Medicine Zenagamtide Helps People With Excess Body Weight Lose Weight Compared to Semaglutide

RecruitingPhase 3
  • Chicago Research Center, Inc, Chicago
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07668414

A Study to Learn About the Study Medicine Called Berobenatide (PF-08653944) in People With Overweight or Obesity

RecruitingPhase 3
  • Cedar Crosse Research Center, Chicago
  • Northwestern University, Chicago
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07595549

A Study of Orforglipron in Participants With Overweight at Risk of Development of Obesity-Related Complications or Progression to Class 1 Obesity

RecruitingPhase 3
  • Great Lakes Clinical Trials - Ravenswood, Chicago
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07794579

AMAZE 9: A Research Study Investigating How Well Zenagamtide Tablets Help People With Excess Body Weight Lose Weight

RecruitingPhase 3
  • Great Lakes Clinical Trials, Chicago
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07720271

Safety and Efficacy of ABBV-295 in Adults With Obesity or Overweight With Weight-Related Comorbidities

RecruitingPhase 2
  • Great Lakes Clinical Trials - West Wilson Avenue /ID# 282378, Chicago
Ages 18 to 75 · All sexes · Updated Sep 25, 2026 · NCT07752979

A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)

RecruitingPhase 3
  • Ann and Robert Lurie Children's Hospital of Chicago, Chicago
  • University of Illinois at Chicago, Chicago
Ages 6 to 17 · All sexes · Updated Sep 24, 2026 · NCT06672549

Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or Overweight

RecruitingPhase 3
  • Rush University Medical Center, Chicago
Ages 18 to 70 · All sexes · Updated Sep 24, 2026 · NCT06937099

Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study

RecruitingPhase 3
  • Rush University Medical Center, Chicago
Ages 18 to 70 · All sexes · Updated Sep 24, 2026 · NCT06937086

Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity

RecruitingPhase 3
  • Eagle Clinical Research, Chicago
  • University of Chicago, Chicago
Ages 45 to 99 · All sexes · Updated Sep 22, 2026 · NCT07037433

A Study to Evaluate Effect of AZD6234 in Adult Participants With Type 2 Diabetes Mellitus and Obesity or Overweight

RecruitingPhase 3
  • Research Site, Chicago
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07784270

A Study of Eloralintide (LY3841136) in Participants With Persistent Obesity Who Are Treated With a Weekly Incretin

RecruitingPhase 3
  • Great Lakes Clinical Trials - Ravenswood, Chicago
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07392190

A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight

RecruitingPhase 2
  • Great Lakes Clinical Trials - Ravenswood, Chicago
Ages 18 to 75 · All sexes · Updated Sep 22, 2026 · NCT07589608

Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight

RecruitingPhase 3
  • Great Lakes Clinical Trials - Ravenswood, Chicago
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07353931

A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight

RecruitingPhase 2
  • Great Lakes Clinical Trials - Ravenswood, Chicago
Ages 18 to 75 · All sexes · Updated Sep 8, 2026 · NCT06143956

Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide (MARITIME-1-EXTENSION)

RecruitingPhase 3
  • Flourish Research - Great Lakes Clinical Trials, Chicago
Ages 18 to 99 · All sexes · Updated Sep 3, 2026 · NCT07684235

BRIDGE & Friends Trial

RecruitingHealthy volunteers welcome
  • University of Illinois Chicago, Chicago
Ages 50 to 79 · All sexes · Updated Sep 1, 2026 · NCT07798557

Assess the Effects of Replacing Foods High in Refined Carbohydrates With Avocado on Biomarkers of Inflammation.

RecruitingHealthy volunteers welcome
  • Illinois Institute of Technology, Chicago
Ages 21 to 74 · All sexes · Updated Aug 27, 2026 · NCT07566325

A Study to Evaluate Effect of AZD6234 in Adult Participants With Obesity or Overweight With Weight-related Comorbidity Without Type 2 Diabetes Mellitus

RecruitingPhase 3
  • Research Site, Chicago
Ages 18 and older · All sexes · Updated Aug 25, 2026 · NCT07784725

Efficacy and Safety of Aleniglipron in Participants With Obesity or Overweight With a Weight-Related Comorbidity (ACCOMPLISH-1)

RecruitingPhase 3
  • ACCOMPLISH-1 Research Site, Chicago
Ages 18 to 79 · All sexes · Updated Aug 10, 2026 · NCT07654361

Functional Improvement in OSA and COPD With a Telehealth LifeStyle and Exercise Intervention

Recruiting
  • Jesse Brown VA Medical Center, Chicago
Ages 18 and older · All sexes · Updated Jul 22, 2026 · NCT06390345

FIM+DASH: Food is Medicine Intervention to Promote Healthy Eating and Blood Pressure Control

RecruitingPhase 2
  • Mile Square Health Center Chicago, Chicago
  • Mile Square Health Center - Auburn Gresham, Chicago
  • Mile Square Health Center - Englewood, Chicago
  • and 1 more
All ages · All sexes · Updated Jul 10, 2026 · NCT07332741

Better Lifestyle Counseling for African American Women During Pregnancy

Recruiting
  • University of Illinois at Chicago, Chicago
  • University of Illinois at Chicago, Chicago
Ages 18 to 40 · Women · Updated Jul 9, 2026 · NCT05234125

People With Multiple Sclerosis Treated With Ocrelizumab and GLP-1 Agonists

RecruitingObservational study
  • Northwestern Memorial Hospital, Chicago
Ages 18 to 70 · All sexes · Updated Mar 17, 2026 · NCT07207148

Semaglutide for Metabolic Intervention and Adipose Loss to Treat Atrial Fibrillation

RecruitingPhase 3
  • University of Chicago, Chicago
Ages 18 to 75 · All sexes · Updated Nov 14, 2025 · NCT06499857

Overweight trials in other cities

Other studies in Chicago

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.