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Sickle Cell Disease clinical trials in North Carolina
18 studies for Sickle Cell Disease are looking for participants at sites in North Carolina.
Cities in North Carolina
A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE)
- East Carolina University, Greenville
- Wake Forest University Baptist Medical Center, Winston-Salem
RecruitingPhase 3
Ages 12 to 100 · All sexes · Updated Sep 28, 2026 · NCT06439082A Phase 1b, Open-Label Study of DISC-3405 in Participants With Sickle Cell Disease (SCD)
- Duke University Medical Center, Durham
- Brody School of Medicine at East Carolina University, Greenville
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07187973A Research Study Looking at Long-term Treatment With Etavopivat in People With Sickle Cell Disease or Thalassaemia
- Atrium Levine Children's/Atrium Health, Charlotte
- Duke University_Durham, Durham
RecruitingPhase 3
Ages 2 and older · All sexes · Updated Sep 18, 2026 · NCT06609226A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease
- Duke Comprehen Sickle Cell, Durham
- Duke University Medical Center, Durham
- East Carolina Univ-Greenville, Greenville
- and 1 more
RecruitingPhase 3
Ages 12 and older · All sexes · Updated Sep 17, 2026 · NCT06612268A Phase I/II Study of ITU512 in Healthy Participants and Patients With Sickle Cell Disease
- Levine Cancer Insitute Carolinas Healthcare System, Charlotte
- East Carolina University, Greenville
RecruitingPhase 1/2Healthy volunteers welcome
Ages 12 to 55 · All sexes · Updated Sep 9, 2026 · NCT06546670A Phase 2/3 Study of Osivelotor in Adult and Adolescent Participants With SCD
- Clinical & Translational Research Center (CTRC), Chapel Hill
- UNC Health, Chapel Hill
- UNC Eastowne Medical Office Building - Consent Only, Chapel Hill
- and 4 more
RecruitingPhase 2/3
Ages 12 and older · All sexes · Updated Aug 18, 2026 · NCT05431088A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease
- Local Institution - 0033, Greenville
RecruitingPhase 1/2Healthy volunteers welcome
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT06481306ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic Disorders
- Comprehensive Hemophilia Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill
- St. Jude Affiliate Clinic at Novant Health Hemby Children's Hospital, Charlotte
- East Carolina University Hemophilia Treatment Center, Greenville
- and 1 more
RecruitingObservational study
All ages · All sexes · Updated Aug 17, 2026 · NCT04398628Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive Crisis
- East Carolina University, Greenville
RecruitingPhase 2
Ages 12 and older · All sexes · Updated Aug 14, 2026 · NCT06699849Comparing the Effectiveness of Matched Related Donor Hematopoietic Stem Cell Transplantation to Disease Modifying Therapy in Pediatric Patients With Sickle Cell Disease
- UNC Children's Hospital (MRD HCT), Chapel Hill
- UNC Children's Hospital (NT-DMT), Chapel Hill
- Atrium Health (MRD-HCT), Charlotte
RecruitingObservational study
Ages 3 to 20 · All sexes · Updated Jun 4, 2026 · NCT06941389Sickle Cell Clinical Research and Intervention Program
- Novant Health Hemby Children's Hospital, Charlotte
RecruitingObservational study
All ages · All sexes · Updated Jun 4, 2026 · NCT02098863SickleFit Exercise and Nutrition Study
- Duke University, Durham
Recruiting
Ages 35 and older · All sexes · Updated May 7, 2026 · NCT07442851Predictors of Pain in Sickle Cell Disease
- Duke University Medical Center, Durham
Recruiting
Ages 15 to 40 · All sexes · Updated May 5, 2026 · NCT06139510ATHNdataset Registry
- American Thrombosis and Hemostasis Network, Hickory
RecruitingObservational study
All ages · All sexes · Updated Apr 21, 2026 · NCT06820515Evaluation of Efficacy and Safety of a Single Dose of CTX001 in Participants With Transfusion-Dependent β-Thalassemia and Severe Sickle Cell Disease
- Levine Children's Hospital - Hematology, Charlotte
RecruitingPhase 3
Ages 12 to 35 · All sexes · Updated Mar 23, 2026 · NCT05477563Zinc Supplementation in Sickle Cell Disease: A Precursor to the Think Zinc for Bones Trial
- Duke University Medical Center, Durham
RecruitingPhase 2
Ages 15 to 40 · All sexes · Updated Mar 13, 2026 · NCT06260891Minimizing Toxicity in HLA-identical Sibling Donor Transplantation for Children With Sickle Cell Disease
- Levine Children's Hospital, Charlotte
RecruitingPhase 2
Ages 2 to 25 · All sexes · Updated Mar 10, 2026 · NCT03587272Peer Support for Adolescents and Emerging Adults With Sickle Cell Pain
- Wake Forest Baptist Hospital, Durham
- East Carolina University Health Medical Center, Greenville
Recruiting
Ages 16 to 30 · All sexes · Updated Jan 7, 2026 · NCT06374238From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.