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Esophageal Cancer clinical trials in Boston, MA

23 studies for Esophageal Cancer are looking for participants at sites in and around Boston (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Distance-Based Exercise to Preserve Function and Prevent Disability

Recruiting
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT07059884

A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors

RecruitingPhase 1
  • Massachusetts General Hospital, Boston
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06465069

A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors

RecruitingPhase 1
  • Brigham and Women's Hospital, Boston
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT07090499

A Phase 1 Study of IM-1617 in Participants With Advanced Cancer

RecruitingPhase 1
  • Massachusetts General Hospital, Boston
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT07578571

A Study of Pembrolizumab With Trastuzumab and Chemotherapy in People With Esophagogastric Cancer

RecruitingPhase 2
  • Massachusetts General Hospital (Data Collection Only), Boston
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT06123338

Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis

RecruitingPhase 1/2
  • Tufts Medical Center, Boston
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT06047379

Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors

RecruitingPhase 1/2
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06128551

A Study of LY4257496 in Participants With Cancer (OMNIRAY)

RecruitingPhase 1
  • Massachusetts General Hospital, Boston
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07114601

A Study of LY4337713 in Participants With FAP-Positive Solid Tumors

RecruitingPhase 1
  • Massachusetts General Hospital, Boston
  • Beth Israel Deaconess Medical Center, Boston
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07213791

Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors

RecruitingPhase 1
  • Massachusetts General Hospital, Boston
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT05983432

Using 18F-FAPI PET to Detect Metastatic Disease in Patients That Have Gastric or Esophageal Cancer.

RecruitingPhase 3
  • Massachusetts General Hospital, Boston
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07217704

Open Label Study to Evaluate BL-M07D1 in HER2 Expressing Malignant Solid Tumors

RecruitingPhase 1
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT06293898

Resilience and Equity in Aging, Cancer, and Health (REACH)

Recruiting
  • Dana-Farber Cancer Institute, Boston
Ages 65 and older · All sexes · Updated Sep 10, 2026 · NCT04674267

Serial MRI Scans During Radiation Therapy

Recruiting
  • Brigham and Women Hospital, Boston
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT04188535

Ivonescimab in Comb. With FOLFOX in Advanced HER2 Neg. GEA

RecruitingPhase 2
  • Massachusetts General Hospital, Boston
Ages 18 and older · All sexes · Updated Aug 28, 2026 · NCT07070466

A Study of STRO-004 in Adults With Refractory/Recurrent Metastatic Cancer

RecruitingPhase 1
  • Mass General Cancer Center, Boston
Ages 18 and older · All sexes · Updated Aug 27, 2026 · NCT07227168

A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors

RecruitingPhase 1/2
  • Massachusetts General Hospital Cancer Center, Boston
Ages 18 and older · All sexes · Updated Aug 11, 2026 · NCT05592626

A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors

RecruitingPhase 1/2
  • Massachusetts General Hospital - Dana Farber, Boston
Ages 18 and older · All sexes · Updated Jul 29, 2026 · NCT03526835

A Study of Sigvotatug Vedotin in Advanced Solid Tumors

RecruitingPhase 1
  • Massachusetts General Hospital, Boston
  • Brigham & Women's Hospital, Boston
  • Beth Israel Deaconess Medical Center,East Campus Research Pharmacy, Boston
  • and 2 more
Ages 18 and older · All sexes · Updated Jul 6, 2026 · NCT04389632

Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors

RecruitingPhase 1/2
  • Massachusetts General Hospital, Boston
Ages 18 and older · All sexes · Updated May 6, 2026 · NCT06239194

Feasibility of the LUM Imaging System for Detection of Gastrointestinal Cancers

RecruitingPhase 1/2
  • Massachusetts General Hospital, Boston
Ages 18 and older · All sexes · Updated Jan 16, 2026 · NCT02584244

About Esophageal Cancer

Early esophageal cancer does not have symptoms. Factors that increase risk include heavy drinking and smoking. Learn how you can reduce your risk.

More about Esophageal Cancer on MedlinePlus

Esophageal Cancer trials in other cities

Other studies in Boston

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.