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Prostate Cancer clinical trials in Boston, MA

61 studies for Prostate Cancer are looking for participants at sites in and around Boston (within about 30 miles). Open a study to see who can join and how to contact the study team.

Barrigel® PPRT (Post-Prostatectomy Radiation Therapy) Trial

Recruiting
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · Men · Updated Sep 28, 2026 · NCT06496256

Precision-Based Genomics in Prostate Cancer

RecruitingObservational study
  • Dana Farber Cancer Institute, Boston, MA, Boston
Ages 18 to 120 · Men · Updated Sep 28, 2026 · NCT04706663

Phase 1 Study of ACE-232 to Treat Patients With Metastatic Castration-Resistant Prostate Cancer

RecruitingPhase 1
  • Harvard Medical School-Massachusetts General Hospital, Boston
Ages 18 and older · Men · Updated Sep 25, 2026 · NCT06801236

Reduce HEAT: A Randomized Trial of Wearable Thermal Devices for ADT-Induced Hot Flashes

Recruiting
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · Men · Updated Sep 25, 2026 · NCT07729150

Study of AZD0516 as Monotherapy and in Combination in Participants With Metastatic Prostate Cancer

RecruitingPhase 1/2
  • Research Site, Boston
Ages 18 to 130 · Men · Updated Sep 25, 2026 · NCT07181161

Study of HLD-0915 (JNJ-101556143) in Patients With Metastatic Prostate Cancer

RecruitingPhase 1/2
  • Dana Farber Mass General Brigham Cancer Care Inc, Boston
Ages 18 and older · Men · Updated Sep 25, 2026 · NCT06800313

A Study in Patients With Metastatic Castration-Resistant Prostate Cancer

RecruitingPhase 1
  • Massachusetts General Hospital, Boston
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · Men · Updated Sep 24, 2026 · NCT07719361

Open-label Study Comparing AAA817 Versus Standard of Care in the Treatment of Previously Treated PSMA-positive mCRPC Adults Who Have Disease Progressed on or After [177Lu]Lu-PSMA Targeted Therapy

RecruitingPhase 2/3
  • Dana Farber Cancer Institute, Boston
  • Beth Israel Deaconess Medical Center, Boston
Ages 18 to 100 · Men · Updated Sep 22, 2026 · NCT06780670

Study Comparing AAA817+ARPI Versus Standard of Care in Adult Participants With PSMA-positive mCRPC

RecruitingPhase 3
  • Beth Israel Deaconess Med Center, Boston
  • Dana Farber Cancer Institute, Boston
Ages 18 to 100 · Men · Updated Sep 22, 2026 · NCT06855277

A Study of LY4257496 in Participants With Cancer (OMNIRAY)

RecruitingPhase 1
  • Massachusetts General Hospital, Boston
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07114601

CV CARE: CardioVascular Care in PC Patients

Recruiting
  • Brigham and Women's Hospital, Boston
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · Men · Updated Sep 22, 2026 · NCT06202820

A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)

RecruitingPhase 3
  • Beth Israel Deaconess Medical Center ( Site 0043), Boston
  • Dana Farber Cancer Institute ( Site 0012), Boston
Ages 18 and older · Men · Updated Sep 17, 2026 · NCT06925737

A Study of [225Ac]Ac-AKY-2519 in Patients With Metastatic Castration-Resistant Prostate Cancer

RecruitingPhase 1
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · Men · Updated Sep 15, 2026 · NCT07581184

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

RecruitingPhase 1/2
  • Massachusetts General Hospital, Boston
  • Dana Farber Cancer Institute, Boston
Ages 12 and older · All sexes · Updated Sep 15, 2026 · NCT04585750

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer

RecruitingPhase 3
  • Brigham and Women's Hospital, Boston
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · Men · Updated Sep 10, 2026 · NCT05946213

Debunking the Frailty-sarcopenIa-ADT Axis in mEtastatic Prostate canceR With multiComponent Exercise: The FIERCE Trial

Recruiting
  • Beth Israel Deaconess Medical Center, Boston
  • Brigham and Women's Hospital, Boston
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · Men · Updated Sep 10, 2026 · NCT06040125

A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors

RecruitingPhase 1
  • Massachusetts General Hospital, Boston
Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT06465069

Serial MRI Scans During Radiation Therapy

Recruiting
  • Brigham and Women Hospital, Boston
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT04188535

Prostate Active Surveillance Study

RecruitingObservational study
  • Beth Israel Deaconess Medical Center/Harvard Medical School, Boston
Ages 21 and older · Men · Updated Sep 2, 2026 · NCT00756665

A Study of Talazoparib With or Without Enzalutamide in People With Prostate Cancer Who Have Previously Received Abiraterone Acetate or Darolutamide

RecruitingPhase 2
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · Men · Updated Aug 21, 2026 · NCT06844383

FOG-001 in Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2
  • Massachusetts General Hospital, Boston
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT05919264

Proof-of-Concept Trial to Assess the Efficacy and Safety of Fezolinetant in Improving Vasomotor Symptoms in Men With Prostate Cancer Undergoing Androgen Deprivation Therapy

RecruitingPhase 2
  • Brigham and Women's Hospital, Boston
Ages 40 and older · Men · Updated Aug 17, 2026 · NCT06957691

Genomic Biomarker-Selected Umbrella Neoadjuvant Study for High Risk Localized Prostate Cancer

RecruitingPhase 2
  • Dana-Farber Cancer Institute / Beth Israel Deaconess Medical Center, Boston
Ages 18 and older · Men · Updated Aug 14, 2026 · NCT04812366

Study of AZD9574 as Monotherapy and in Combination With Anti-cancer Agents in Participants With Advanced Solid Malignancies

RecruitingPhase 1/2
  • Research Site, Boston
Ages 18 to 130 · All sexes · Updated Aug 12, 2026 · NCT05417594

A Trial to Learn How Safe AZD9750 is and How Well it Works in People With Metastatic Prostate Cancer When Given With or Without Other Anticancer Drugs

RecruitingPhase 1/2
  • Research Site, Boston
Ages 18 and older · Men · Updated Aug 10, 2026 · NCT07336446

A Study to Assess BMS-986460 in Participants With Metastatic Castration-resistant Prostate Cancer

RecruitingPhase 1
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · Men · Updated Aug 10, 2026 · NCT06067841

Distance-Based Exercise to Preserve Function and Prevent Disability

Recruiting
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT07059884

RecoverPC: Relugolix vs GnRH Agonist in Quality of Life

RecruitingPhase 2
  • Brigham and Women's Hospital, Boston
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · Men · Updated Jul 30, 2026 · NCT05765500

Exercise to Enhance Cardiovascular Health Among Black Prostate Cancer Patients With Androgen Deprivation Therapy

Recruiting
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · Men · Updated Jul 29, 2026 · NCT05327465

Jump: MR Simulation For Radiation Therapy Master Protocol

Recruiting
  • Brigham and Women Hospital, Boston
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Jul 20, 2026 · NCT04545957

Study of CX-5461 in Patients With Solid Tumours and BRCA1/2, PALB2 or Homologous Recombination Deficiency (HRD) Mutation

RecruitingPhase 1
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Jun 8, 2026 · NCT04890613

Androgen-responsive POSLUMA-guided Intra-prostatic Boost

RecruitingPhase 2
  • Brigham and Women's Hospital, Boston
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · Men · Updated May 29, 2026 · NCT07393867

Robotic Opioid-free Prostatectomy Enhanced Strategy (ROPES)

RecruitingPhase 3
  • Brigham and Women's Hospital, Boston
  • Brigham and Women's Faulkner Hospital, Boston
Ages 45 and older · Men · Updated May 22, 2026 · NCT07427043

Video Education With Result Dependent dIsclosure

Recruiting
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated May 22, 2026 · NCT05225428

International Registry for Men With Advanced Prostate Cancer (IRONMAN)

RecruitingObservational study
  • Dana-Farber Cancer Institute, Boston
Ages 21 and older · Men · Updated May 22, 2026 · NCT03151629

Flotufolastat F 18 PET in Men With Very Low PSA Recurrence

RecruitingObservational study
  • Massachusetts General Hospital, Boston
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · Men · Updated May 15, 2026 · NCT06862856

Prostate Cancer Screening for People at Genetic Risk for Aggressive Disease, PATROL Study

RecruitingObservational studyHealthy volunteers welcome
  • Massachusetts General Hospital, Boston
Ages 40 and older · Men · Updated May 15, 2026 · NCT04472338

A Phase I Study of [225Ac]-AZD2284 in Patients With Metastatic Castration-Resistant Prostate Cancer

RecruitingPhase 1
  • Research Site, Boston
Ages 18 and older · Men · Updated May 12, 2026 · NCT06879041

Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors

RecruitingPhase 1/2
  • Massachusetts General Hospital, Boston
Ages 18 and older · All sexes · Updated May 6, 2026 · NCT06239194

Clinical Trial of Approaches to Prostate Cancer Surgery

Recruiting
  • Beth Israel Deaconess Medical Center (BIDMC), Boston
Ages 40 to 80 · Men · Updated Apr 22, 2026 · NCT05155501

Phase I/II Trial of Pembrolizumab and Androgen-receptor Inhibitor With or Without 225Ac-J591 for Progressive Metastatic Castration Resistant Prostate Cancer

RecruitingPhase 1/2
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · Men · Updated Apr 21, 2026 · NCT04946370

Veterans Affairs Seamless Phase II/III Randomized Trial of STAndard Systemic theRapy With or Without PET-directed Local Therapy for Oligometastatic pRosTate Cancer

RecruitingPhase 2/3
  • VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston
Ages 18 and older · Men · Updated Apr 8, 2026 · NCT04787744

This is a Phase 1 Trial of ZM008, an Anti-LLT1 Antibody, Used as Single Agent Followed by Combination Treatment With Toripalimab in Patients With Advanced Solid Tumors

RecruitingPhase 1
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Apr 2, 2026 · NCT06451497

A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies

RecruitingPhase 1/2
  • Massachusetts General Hospital, Boston
Ages 18 and older · All sexes · Updated Mar 27, 2026 · NCT06395519

Study of AZD0754 in Participants With Metastatic Prostate Cancer

RecruitingPhase 1/2
  • Research Site, Boston
  • Research Site, Boston
Ages 18 to 130 · Men · Updated Feb 23, 2026 · NCT06267729

Pilot of 18F-DCFPyL-PSMA PET in mCRPC Patients Receiving 117Lu-Vipivotide Tetraxetan

RecruitingPhase 4
  • Dana Farber Cancer Institute, Boston
  • Brigham and Womens Hospital, Boston
Ages 18 and older · Men · Updated Jan 29, 2026 · NCT06099093

Effect on Body Movement and Mental Skills in Patients Who Received Gadolinium-based Contrast Media for Magnetic Resonance Examination Multiple Times Within 5 Years

RecruitingPhase 4
  • Massachussets General Hospital, Boston
Ages 18 to 64 · All sexes · Updated Jan 22, 2026 · NCT04373564

The Prostate Cancer, Genetic Risk, and Equitable Screening Study (ProGRESS)

RecruitingHealthy volunteers welcome
  • VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston
Ages 55 to 69 · Men · Updated Jan 13, 2026 · NCT05926102

MRI Guided Prostate Biopsy

Recruiting
  • Brigham and Women's Hospital, Boston
Ages 30 and older · Men · Updated Dec 3, 2025 · NCT06302595

Circulating Tumor Cell Analysis in Patients With Localized Prostate Cancer Undergoing Prostatectomy

RecruitingObservational study
  • Massachsuetts General Hospital, Boston
Ages 18 and older · Men · Updated Nov 25, 2025 · NCT01961713

Stereotactic Magnetic Resonance Guided Radiation Therapy

Recruiting
  • Brigham & Women's Hospital, Boston
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Nov 13, 2025 · NCT04115254

Polygenic Risk Stratification Combined With mpMRI to Identify Clinically Relevant Prostate Cancer

RecruitingHealthy volunteers welcome
  • Massachusetts General Hospital, Boston
  • Brigham and Women's Hospital, Boston
Ages 40 to 69 · Men · Updated Nov 10, 2025 · NCT06398639

Pilot Study for Detection of PSMA-Low CRPC-NE Tumors With Fluciclovine PET/CT

RecruitingPhase 1
  • Dana Farber Cancer Institute, Boston
  • Brigham and Womens Hospital, Boston
Ages 18 and older · Men · Updated Nov 5, 2025 · NCT06062745

Comprehensive Outcomes for After Cancer Health

RecruitingHealthy volunteers welcome
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Dec 11, 2024 · NCT05349227

ART-Pro: Clinical Trial Evaluating Biparametric MRI and Advanced, Quantitative Diffusion MRI for Detection of Prostate Cancer

RecruitingObservational study
  • Massachusetts General Hospital, Boston
Ages 18 and older · Men · Updated Nov 6, 2024 · NCT06579417

Prostate Cancer Genetic Risk Evaluation and Screening Study

RecruitingObservational study
  • Massachusetts General Hospital, Boston
Ages 35 to 74 · Men · Updated Oct 9, 2024 · NCT05129605

A Novel Imaging Protocol in Use to Identify Lymph Nodes and Organs of Interest

Recruiting
  • Brigham and Women's Hospital, Boston
Ages 18 and older · All sexes · Updated Oct 24, 2023 · NCT05899361

About Prostate Cancer

Prostate cancer is one of the most common types of cancer among American men. The risk goes up as men age. Learn about symptoms, tests, and treatment.

More about Prostate Cancer on MedlinePlus

Prostate Cancer trials in other cities

Other studies in Boston

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.