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Ovarian Cancer clinical trials in Boston, MA

61 studies for Ovarian Cancer are looking for participants at sites in and around Boston (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

RecruitingPhase 2
  • Tufts Medical Center, Boston
  • Dana-Farber Cancer Institute, Boston
All ages · All sexes · Updated Oct 2, 2026 · NCT05564377

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

RecruitingPhase 1/2
  • Massachusetts General Hospital, Boston
  • Dana Farber Cancer Institute, Boston
Ages 12 and older · All sexes · Updated Oct 2, 2026 · NCT04585750

Distance-Based Exercise to Preserve Function and Prevent Disability

Recruiting
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT07059884

A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors

RecruitingPhase 1
  • Massachusetts General Hospital, Boston
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06465069

A Study With NKT3964 for Adults With Advanced/Metastatic Solid Tumors

RecruitingPhase 1
  • Dana Farber Cancer Institute, Boston
Ages 19 and older · All sexes · Updated Oct 1, 2026 · NCT06586957

A Study of NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation

RecruitingPhase 1
  • Research Site, Boston
  • Research Site, Boston
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT05877599

A Study of Azenosertib (ZN-c3) in Subjects With Platinum-Resistant High-Grade Serous Ovarian, Fallopian Tube or Primary Peritoneal Cancer

RecruitingPhase 2
  • Site 0221 - Tufts Medical Center - PPDS, Boston
  • Site 0104 - Dana Farber Cancer Institute, Boston
Ages 18 and older · Women · Updated Sep 29, 2026 · NCT05128825

Study of REGN4018 (Ubamatamab) Administered Alone or in Combination With Cemiplimab in Adult Patients With Recurrent Ovarian Cancer or Other Recurrent Mucin-16 Expressing (MUC16+) Cancers

RecruitingPhase 1/2
  • Massachusetts General Hospital, Boston
  • Dana Farber / Harvard Cancer Center, Boston
Ages 18 and older · Women · Updated Sep 25, 2026 · NCT03564340

A Study to Find Out How Safe REGN5668 is and How Well it Works In Adult Women When Given With Either Cemiplimab, or Cemiplimab + Fianlimab, or Ubamatamab

RecruitingPhase 1/2
  • Massachusetts General Hospital, Boston
  • Dana Farber Cancer Institute Brookline Avenue, Boston
Ages 18 and older · Women · Updated Sep 24, 2026 · NCT04590326

Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors

RecruitingPhase 1/2
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06128551

A Study of LY4337713 in Participants With FAP-Positive Solid Tumors

RecruitingPhase 1
  • Massachusetts General Hospital, Boston
  • Beth Israel Deaconess Medical Center, Boston
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07213791

Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors

RecruitingPhase 1
  • Massachusetts General Hospital, Boston
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT05983432

A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations

RecruitingPhase 1/2
  • Massachusetts General Hospital, Boston
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07109726

Sacituzumab Tirumotecan +/- Pembrolizumab in I/O Exposed Metastatic or Recurrent Ovarian Clear Cell Cancer

RecruitingPhase 2
  • Tufts Medical Center, Boston
Ages 18 and older · Women · Updated Sep 16, 2026 · NCT07718854

A Study of Isoquercetin in People With Ovarian Cancer

RecruitingPhase 2
  • Beth Israel Deaconess Medical Center (Data Collection Only), Boston
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT07303894

A Study of INCB123667 in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression

RecruitingPhase 2
  • Massachusetts General Hospital, Boston
Ages 18 to 99 · Women · Updated Sep 15, 2026 · NCT07023627

FiH Study to Investigate Safety, PK and Efficacy of the NaPi2b ADC TUB-040 in Patients With PROC or r/r Adenocarcinoma NSCLC

RecruitingPhase 1/2
  • Tufts, Boston
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT06303505

Minimally Invasive Surgery After Neoadjuvant Chemotherapy for the Treatment of Stage IIIC-IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer, LANCE Trial

RecruitingPhase 3
  • Massachusetts General Hospital, Boston
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · Women · Updated Sep 14, 2026 · NCT04575935

Investigation of Ubamatamab Combination Therapy in Adult Participants With Platinum-Resistant Ovarian Cancer

RecruitingPhase 2
  • Massachusetts General Hospital, Boston
Ages 18 and older · Women · Updated Sep 14, 2026 · NCT06787612

A Phase I/IIa Study of AZD8205 Given Alone or Combined, in Participants With Advanced/Metastatic Solid Malignancies

RecruitingPhase 1/2
  • Research Site, Boston
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT05123482

DT2216 + Paclitaxel in Platinum-Resistant Ovarian Cancer

RecruitingPhase 1
  • Beth Israel Deaconess Medical Center (BIDMC), Boston
  • Dana Farber Cancer Institute, Boston
  • Brigham and Women's Hospital, Boston
Ages 18 and older · Women · Updated Sep 11, 2026 · NCT06964009

Open Label Study to Evaluate BL-M07D1 in HER2 Expressing Malignant Solid Tumors

RecruitingPhase 1
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT06293898

Phase 1 Study to Assess Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Antitumor Activity of ARR-002 in Advanced or Metastatic Ovarian or Endometrial Cancer.

RecruitingPhase 1
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · Women · Updated Sep 3, 2026 · NCT07755436

Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors

RecruitingPhase 1/2
  • Dana-Farber Cancer Institute, Boston
12 Months – 30 Years · All sexes · Updated Aug 25, 2026 · NCT04851119

A Phase 1 Study of LNCB74 in Advanced Solid Tumors

RecruitingPhase 1
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Aug 21, 2026 · NCT06774963

Phase I/IIa Study of AZD5335 as Monotherapy and Combination Therapy in Participants With Solid Tumors

RecruitingPhase 1/2
  • Research Site, Boston
Ages 18 to 130 · All sexes · Updated Aug 21, 2026 · NCT05797168

A Phase 1 Study of NRM-823 in Participants With Locally Advanced or Metastatic Refractory Solid Tumors

RecruitingPhase 1
  • Normunity Investigational Site, Boston
  • Normunity Investigational Site, Boston
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT07182149

A Study of PHST001 in Advanced Solid Tumors

RecruitingPhase 1
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Aug 12, 2026 · NCT06840886

Study of AZD9574 as Monotherapy and in Combination With Anti-cancer Agents in Participants With Advanced Solid Malignancies

RecruitingPhase 1/2
  • Research Site, Boston
Ages 18 to 130 · All sexes · Updated Aug 12, 2026 · NCT05417594

A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer

Recruiting
  • Beth Israel Deaconess Medical Center, Boston
Ages 35 to 50 · Women · Updated Aug 7, 2026 · NCT04251052

Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001)

RecruitingPhase 1/2
  • Massachusetts General Hospital, Boston
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Aug 4, 2026 · NCT05579366

A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations

RecruitingPhase 2
  • Tufts Medical Center, Boston
  • Massachusetts General Hospital, Boston
  • Dana-Farber Cancer Institute, Boston
Ages 8 and older · All sexes · Updated Jul 27, 2026 · NCT05503797

A Trial to Evaluate Safety, Tolerability, and Preliminary Efficacy of Misetionamide (GP-2250) as Monotherapy or in Combination With Gemcitabine

RecruitingPhase 1
  • Beth Israel Deaconess Medical Center, Boston
Ages 18 and older · Women · Updated Jul 23, 2026 · NCT03854110

First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors

RecruitingPhase 1/2
  • Massachusetts General Hospital, Boston
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Jul 7, 2026 · NCT05768139

A Study of Sigvotatug Vedotin in Advanced Solid Tumors

RecruitingPhase 1
  • Massachusetts General Hospital, Boston
  • Brigham & Women's Hospital, Boston
  • Beth Israel Deaconess Medical Center,East Campus Research Pharmacy, Boston
  • and 2 more
Ages 18 and older · All sexes · Updated Jul 6, 2026 · NCT04389632

A First-in-Human Study of MEN2501 in Participants With Platinum-Resistant Ovarian Cancer

RecruitingPhase 1
  • Massachusetts General Hospital, Boston
Ages 18 and older · Women · Updated Jul 6, 2026 · NCT07226427

Study of Trastuzumab Deruxtecan With Bevacizumab Versus Bevacizumab Monotherapy for First-line Maintenance in HER2-Expressing Ovarian Cancer (DESTINY-Ovarian01)

RecruitingPhase 3
  • Massachusetts General Hospital, Boston
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · Women · Updated Jul 2, 2026 · NCT06819007

A Study of Emiltatug Ledadotin (Emi-Le) in Participants With Solid Tumors

RecruitingPhase 1/2
  • Beth Israel Deaconess Medical Center, Boston
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Jun 29, 2026 · NCT05377996

A Long-term Treatment Extension Study of Niraparib in Participants Who Completed a Prior GlaxoSmithKline/TESARO-sponsored Niraparib Study

RecruitingPhase 2
  • GSK Investigational Site, Boston
Ages 18 and older · All sexes · Updated Jun 24, 2026 · NCT04641247

Phase 1/2 Study of ETX-636 in Participants With Advanced Solid Tumors

RecruitingPhase 1/2
  • Beth Israel Deaconess Medical Center, Boston
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Jun 23, 2026 · NCT06993844

Pilot Randomized Controlled Trial of a Collaborative Agenda-setting Intervention (CASI) for Patients With Ovarian Cancer

Recruiting
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · Women · Updated Jun 17, 2026 · NCT06543537

Intraperitoneal Cytokine-Induced Memory Like (CIML) Natural Killer (NK) Cells in Recurrent Ovarian Cancer

RecruitingPhase 1
  • Brigham and Women's Hospital, Boston
  • Dana-Farber Cancer Institute, Boston
Ages 18 to 85 · All sexes · Updated Jun 16, 2026 · NCT06321484

Study of CX-5461 in Patients With Solid Tumours and BRCA1/2, PALB2 or Homologous Recombination Deficiency (HRD) Mutation

RecruitingPhase 1
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Jun 8, 2026 · NCT04890613

Video Education With Result Dependent dIsclosure

Recruiting
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated May 22, 2026 · NCT05225428

Microdevice In Ovarian, Fallopian Tube, And Peritoneal Cancer

RecruitingPhase 1
  • Brigham and Women's Hospital, Boston
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · Women · Updated May 18, 2026 · NCT04701645

ACTengine® IMA203/IMA203CD8 as Monotherapy or in Combination With Nivolumab in Recurrent and/or Refractory Solid Tumors

RecruitingPhase 1/2
  • Massachusetts General Hospital, Boston
Ages 18 and older · All sexes · Updated May 13, 2026 · NCT03686124

REVITALIZE: RCT to Reduce Fatigue in Adults With Ovarian Cancer on PARP Inhibitors

Recruiting
  • Massachusetts General Hospital-Cancer Center, Boston
  • Beth Israel Deaconess Medical Center, Boston
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · Women · Updated Apr 13, 2026 · NCT06710548

A Study of Azenosertib (ZN-c3) in Patients With Ovarian Cancer

RecruitingPhase 1
  • Site 0104, Boston
Ages 18 and older · Women · Updated Apr 7, 2026 · NCT04516447

TUBectomy With Delayed Oophorectomy in High Risk Women to Assess the Safety of Prevention

Recruiting
  • Dana Farber Cancer Institute, Boston
Ages 25 to 50 · Women · Updated Apr 6, 2026 · NCT04294927

Open-Label Study to Evaluate the Safety, Tolerability, PK, and Efficacy of INX-315 in Patients With Advanced Cancer

RecruitingPhase 1/2
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Apr 1, 2026 · NCT05735080

A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies

RecruitingPhase 1/2
  • Massachusetts General Hospital, Boston
Ages 18 and older · All sexes · Updated Mar 27, 2026 · NCT06395519

Exercise as a Preventive Agent to Combat Immobility in Patients With Ovarian or Endometrial Cancers Receiving Chemotherapy

Recruiting
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · Women · Updated Feb 19, 2026 · NCT04997096

A Study of CUSP06 in Patients With Platinum-Refractory/Resistant Ovarian Cancer and Other Advanced Solid Tumors

RecruitingPhase 1
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Jan 14, 2026 · NCT06234423

CATALINA-2: A Clinical Study of TORL-1-23 in Platinum-resistant Ovarian Cancer.

RecruitingPhase 2
  • Massachusetts General Hospital, Boston
Ages 18 and older · Women · Updated Dec 23, 2025 · NCT06690775

Belzutifan in Recurrent Clear Cell Carcinoma of Gynecologic Origin

RecruitingPhase 2
  • Brigham and Women's Hospital, Boston
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · Women · Updated Nov 5, 2025 · NCT06677190

A Study to Evaluate TROP2 ADC LCB84 Single Agent and in Combination With an Anti-PD-1 Ab in Advanced Solid Tumors

RecruitingPhase 1/2
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Sep 24, 2025 · NCT05941507

Developing a Test of Uterine Lavage for the Detection of Ovarian Cancer

RecruitingObservational study
  • Massachusetts General Hospital, Boston
Ages 30 and older · Women · Updated Sep 16, 2025 · NCT04794322

Comprehensive Outcomes for After Cancer Health

RecruitingHealthy volunteers welcome
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Dec 11, 2024 · NCT05349227

About Ovarian Cancer

Ovarian cancer is a cancerous tumor that forms in the tissues of an ovary. The ovaries are a pair of female reproductive glands that make eggs and female hormones.

More about Ovarian Cancer on MedlinePlus

Ovarian Cancer trials in other cities

Other studies in Boston

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.