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Esophageal Cancer clinical trials in Houston, TX

36 studies for Esophageal Cancer are looking for participants at sites in and around Houston (within about 30 miles). Open a study to see who can join and how to contact the study team.

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A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors

RecruitingPhase 1
  • University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06465069

A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)

RecruitingPhase 2
  • The University of Texas MD Anderson Cancer Center - Texas Medical Center, Houston
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06760819

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • UT MD Anderson Cancer Center, Houston
Ages 40 to 75 · All sexes · Updated Oct 2, 2026 · NCT05334069

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 2
  • The University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06172478

A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors

RecruitingPhase 1
  • University of Texas MD Anderson Cancer Center, Houston
  • The University of Texas, MD Anderson Cancer Center - West Houston, Houston
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT07090499

A Study of Pembrolizumab With Trastuzumab and Chemotherapy in People With Esophagogastric Cancer

RecruitingPhase 2
  • MD Anderson Cancer Center (Data Collection Only), Houston
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT06123338

Pan-tumor MRD Study

RecruitingObservational study
  • Onocology Consultants P.A. (Oncology Consultants [OC Houston]), Houston
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT06605404

A Study of LY4257496 in Participants With Cancer (OMNIRAY)

RecruitingPhase 1
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07114601

A Study of LY4337713 in Participants With FAP-Positive Solid Tumors

RecruitingPhase 1
  • Baylor College of Medicine, Houston
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07213791

Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors

RecruitingPhase 1/2
  • MD Anderson, Houston
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06128551

Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors

RecruitingPhase 1
  • Oncology Consultants, P.A., Houston
  • University of Texas M.D. Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT05983432

Open Label Study to Evaluate BL-M07D1 in HER2 Expressing Malignant Solid Tumors

RecruitingPhase 1
  • Oncology Consultants, Houston
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT06293898

Substudy 06D: Combination Therapies in Second Line (2L) Gastroesophageal Adenocarcinoma (MK-3475-06D/Keymaker-U06)

RecruitingPhase 1/2
  • University of Texas MD Anderson Cancer Center ( Site 8920), Houston
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT06445972

Substudy 06C: A Study of Investigational Agents With Pembrolizumab (MK-3475) and Chemotherapy in Participants With First-Line Locally Advanced Unresectable/Metastatic Gastroesophageal Adenocarcinoma (MK-3475-06C/KEYMAKER-U06)

RecruitingPhase 1/2
  • University of Texas MD Anderson Cancer Center ( Site 6920), Houston
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT06469944

A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors

RecruitingPhase 1/2
  • The University of Texas, MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Aug 11, 2026 · NCT05592626

IDOV-Immune for Advanced Solid Tumors

RecruitingPhase 1
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT06910657

A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors

RecruitingPhase 1/2
  • Oncology Consultants, Houston
Ages 18 and older · All sexes · Updated Jul 29, 2026 · NCT03526835

A Phase 2 Study of Zanidatamab in Patients With HER2-expressing Tumors

RecruitingPhase 2
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Jul 10, 2026 · NCT06695845

Lead-212 PSV359 Therapy for Patients With Solid Tumors

RecruitingPhase 1/2
  • MD Anderson Cancer Center, Houston
Ages 18 to 90 · All sexes · Updated Jul 6, 2026 · NCT06710756

A Study of Sigvotatug Vedotin in Advanced Solid Tumors

RecruitingPhase 1
  • Oncology Consultants, PA, Houston
  • Oncology Consultants, PA., Houston
  • The University of Texas M.D. Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Jul 6, 2026 · NCT04389632

Data Collection for the Assessment of Acute and Late Normal Tissue in Patients Treated With Proton Therapy

RecruitingObservational study
  • M D Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Jun 12, 2026 · NCT00991094

Serologic Response to Pneumococcal Vaccination Among Esophageal Cancer Patients With High Grade Lymphopenia After Chemoradiation

RecruitingObservational studyHealthy volunteers welcome
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated May 20, 2026 · NCT06181656

18F-AraG PET/CT as a Non-Invasive Imaging Biomarker for Chemoradiation Treatment Response in Esophageal Cancer

RecruitingPhase 1
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated May 19, 2026 · NCT06414902

Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors

RecruitingPhase 1/2
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated May 6, 2026 · NCT06239194

Dyadic Yoga Intervention in Improving Physical Performance and Quality of Life in Patients With Stage I-IV Non-small Cell Lung or Esophageal Cancer Undergoing Radiotherapy and Their Caregivers

RecruitingHealthy volunteers welcome
  • M D Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Apr 15, 2026 · NCT03948100

Chemotherapy With or Without Radiation or Surgery in Treating Participants With Oligometastatic Esophageal or Gastric Cancer

RecruitingPhase 2
  • M D Anderson Cancer Center, Houston
Ages 18 to 79 · All sexes · Updated Apr 15, 2026 · NCT03161522

Novel Bipolar Radiofrequency Ablation Knife in Esophageal Lesions

RecruitingObservational study
  • Baylor College of Medicine, Houston
Ages 18 and older · All sexes · Updated Mar 25, 2026 · NCT06476678

The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study

RecruitingObservational study
  • Md Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Mar 5, 2026 · NCT04075305

Binary Oncolytic Adenovirus in Combination With HER2-Specific Autologous CAR VST, Advanced HER2 Positive Solid Tumors

RecruitingPhase 1
  • Baylor St. Luke's Medical Center, Houston
Ages 18 and older · All sexes · Updated Feb 6, 2026 · NCT03740256

A Study to Evaluate the Safety, Pharmacokinetics and Efficacy of TJ101 in Patients With Advanced/Metastatic Solid Tumors

RecruitingPhase 1
  • Oncology Consultants, Houston
Ages 18 and older · All sexes · Updated Jan 12, 2026 · NCT07181473

A Study of MT-4561 in Patients With Various Advanced Solid Tumors

RecruitingPhase 1/2
  • The University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Dec 11, 2025 · NCT06943521

VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma

RecruitingPhase 1/2
  • The University of Texas MD Anderson Cancer Center (site 127), Houston
Ages 18 to 80 · All sexes · Updated Dec 11, 2025 · NCT03556228

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Houston
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

Distribution of Lymph Node Metastases in Esophageal Carcinoma

RecruitingObservational study
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Feb 13, 2024 · NCT03222895

About Esophageal Cancer

Early esophageal cancer does not have symptoms. Factors that increase risk include heavy drinking and smoking. Learn how you can reduce your risk.

More about Esophageal Cancer on MedlinePlus

Esophageal Cancer trials in other cities

Other studies in Houston

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.