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Metastatic Cancer clinical trials in Baltimore, MD

28 studies for Metastatic Cancer are looking for participants at sites in and around Baltimore (within about 30 miles). Open a study to see who can join and how to contact the study team.

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Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

RecruitingPhase 2
  • University of Maryland/Greenebaum Cancer Center, Baltimore
All ages · All sexes · Updated Oct 5, 2026 · NCT05564377

Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer

RecruitingPhase 3
  • Greater Baltimore Medical Center, Baltimore
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07222800

A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue

RecruitingPhase 2/3
  • JHU Oncology Central Kit Services, Baltimore
  • Johns Hopkins Hospital, Baltimore
  • Oncology Investigational Drug Service (IDS), Baltimore
  • and 1 more
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06989437

Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

RecruitingPhase 3
  • Maryland Oncology Hematology, P.A., Annapolis · 22 mi away
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07222566

Safety and Preliminary Anti-Tumor Activity of TYRA-430 in Advanced Hepatocellular Carcinoma and Other Solid Tumors With Activating FGF/FGFR Pathway Aberrations

RecruitingPhase 1
  • John Hopkins University, Baltimore
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT06915753

A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer

RecruitingPhase 3
  • Greater Baltimore Medical Center, Baltimore
  • Sinai Hospital Of Baltimore, Baltimore
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07213804

A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract

RecruitingPhase 3
  • Johns Hopkins Hospital, Baltimore
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07218380

A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

RecruitingPhase 3
  • Johns Hopkins Bayview Medical Center, Baltimore
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT06119581

NPX372, a B7-H7:CD3 Bispecific Antibody, in Selected Solid Tumor Malignancies

RecruitingPhase 1
  • Johns Hopkins, Baltimore
Ages 19 and older · All sexes · Updated Sep 8, 2026 · NCT07563829

FORAGER-1: A Study of Vepugratinib (LY3866288; LOXO-435) in Participants With Cancer With a Change in a Gene Called FGFR3

RecruitingPhase 1
  • Johns Hopkins Kimmel Cancer Center, Baltimore
Ages 18 and older · All sexes · Updated Aug 20, 2026 · NCT05614739

A Study of Novel Study Interventions and Combinations in Participants With Colorectal Cancer

RecruitingPhase 2
  • Research Site, Baltimore
Ages 18 to 130 · All sexes · Updated Aug 18, 2026 · NCT06792695

FOG-001 in Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2
  • Johns Hopkins University, The Sidney Kimmel Comprehensive Cancer Center, Baltimore
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT05919264

Puxitatug Samrotecan (AZD8205) Monotherapy vs Chemotherapy in B7-H4-selected Endometrial Cancer (Bluestar-Endometrial01)

RecruitingPhase 3
  • Research Site, Baltimore
  • Research Site, Baltimore
Ages 18 and older · Women · Updated Jul 29, 2026 · NCT07044336

REMASTer: REcurrent Brain Metastases After SRS Trial

Recruiting
  • University of Maryland, Baltimore
Ages 18 and older · All sexes · Updated Jun 18, 2026 · NCT05124912

Safety and Tolerability of ²¹²Pb-DOTAM-GRPR1 in Adult Subjects With Recurrent or Metastatic GRPR-expressing Tumors

RecruitingPhase 1
  • Advanced Molecular Imaging and Therapy, Glen Burnie · 9 mi away
  • United Theranostics - Chesapeake, Glen Burnie · 9 mi away
Ages 18 and older · All sexes · Updated Jun 11, 2026 · NCT05283330

Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors

RecruitingPhase 1
  • Johns Hopkins University, Baltimore
Ages 18 and older · All sexes · Updated Jun 3, 2026 · NCT06040541

Study of Sacituzumab Govitecan in Participants With Advanced or Metastatic Solid Tumor and Moderate Liver Impairment

RecruitingPhase 1
  • University of Maryland, Baltimore
Ages 18 and older · All sexes · Updated Jun 2, 2026 · NCT04617522

A Study of Neladalkib (NVL-655) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ALK Rearrangement or Activating ALK Mutation (ALKOVE-1)

RecruitingPhase 1/2
  • John Hopkins University, Baltimore
Ages 12 and older · All sexes · Updated May 27, 2026 · NCT05384626

Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS

RecruitingPhase 1/2
  • Johns Hopkins University, Baltimore
Ages 18 and older · All sexes · Updated May 15, 2026 · NCT05379985

A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors

RecruitingPhase 1/2
  • Johns Hopkins University, Baltimore
Ages 18 and older · All sexes · Updated Apr 22, 2026 · NCT07020221

A Study of Ficlatuzumab in Combination With Cetuximab in Participants With Recurrent or Metastatic (R/M) HPV Negative Head and Neck Squamous Cell Carcinoma

RecruitingPhase 3
  • University of Maryland, Baltimore
Ages 18 and older · All sexes · Updated Apr 9, 2026 · NCT06064877

Veterans Affairs Seamless Phase II/III Randomized Trial of STAndard Systemic theRapy With or Without PET-directed Local Therapy for Oligometastatic pRosTate Cancer

RecruitingPhase 2/3
  • Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD, Baltimore
Ages 18 and older · Men · Updated Apr 8, 2026 · NCT04787744

A Study of NVL-330 in Patients With Advanced or Metastatic HER2-altered NSCLC (HEROEX-1)

RecruitingPhase 1
  • Johns Hopkins Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Bayview Medical Center, Baltimore
Ages 18 and older · All sexes · Updated Feb 25, 2026 · NCT06521554

A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

RecruitingPhase 1
  • Johns Hopkins - Sidney Kimmel Comprehensive Cancer Center, Baltimore
Ages 18 and older · All sexes · Updated Feb 13, 2026 · NCT06778863

Ivosidenib in Participants With Locally Advanced or Metastatic Conventional Chondrosarcoma Untreated or Previously Treated With 1 Systemic Treatment Regimen

RecruitingPhase 3
  • Johns Hopkins University, Baltimore
Ages 18 and older · All sexes · Updated Feb 6, 2026 · NCT06127407

A Safety and Dose-finding Study of PRL-02 Depot in Men With Advanced Prostate Cancer

RecruitingPhase 1
  • Chesapeake Urology, Towson · 8 mi away
Ages 18 and older · Men · Updated Feb 4, 2026 · NCT04729114

Evaluation of RBS2418 in Subjects With Advanced, Metastatic Solid Tumors

RecruitingPhase 1
  • Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore
Ages 18 and older · All sexes · Updated Dec 19, 2025 · NCT05270213

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Baltimore
  • Massive Bio SYNERGY-AI site, Towson · 8 mi away
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

Metastatic Cancer trials in other cities

Other studies in Baltimore

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.