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Amyotrophic Lateral Sclerosis clinical trials in Massachusetts
23 studies for Amyotrophic Lateral Sclerosis are looking for participants at sites in Massachusetts.
Cities in Massachusetts
RAPA-501 Therapy for ALS
- Massachusetts General Hospital, Boston
RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT04220190A Study to Investigate the Safety and Pharmacodynamics of a Single Intrathecal Injection (IT) of INS1202 in Participants With Amyotrophic Lateral Sclerosis (ALS)
- USA009, Worcester
RecruitingPhase 1
Ages 18 to 79 · All sexes · Updated Sep 23, 2026 · NCT07290062Pridopidine Phase 3 Study to Evaluate Efficacy and Safety in ALS
- Sean M. Healey & AMG Center for ALS, Boston
RecruitingPhase 3
Ages 18 to 80 · All sexes · Updated Sep 22, 2026 · NCT07322003RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses
- Dana Farber Cancer Institute, Boston
- University of Massachusetts Chan Medical Center, Worcester
RecruitingPhase 2
Ages 18 to 80 · All sexes · Updated Sep 15, 2026 · NCT07002034Study is to Assess the Safety and Tolerability of VTx-002 in Participants With ALS
- Sean M. Healey & AMG Center for ALS at Massachusetts General Hospital, Boston
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT07287397Controlling Amyotrophic Lateral Sclerosis Motor Neuron Excitability Study
- Beth Israel Deaconess Medical Center, Boston
Recruiting
Ages 18 to 80 · All sexes · Updated Sep 10, 2026 · NCT06649955Usnoflast Neuromuscular Investigation for Treatment Efficacy in Amyotrophic Lateral Sclerosis
- Zydus US010, Boston
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 1, 2026 · NCT07023835ASSESS ALL ALS Study
- Massachusetts General Brigham, Boston
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Aug 24, 2026 · NCT06578195PREVENT ALL ALS Study
- Massachusetts General Brigham, Boston
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Aug 24, 2026 · NCT06581861Study of COYA 302 for the Treatment of ALS
- Massachusetts General Hospital, Boston
RecruitingPhase 2/3
Ages 18 to 80 · All sexes · Updated Aug 6, 2026 · NCT07161999ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)
- Massachusetts General Hospital, Boston
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Jul 30, 2026 · NCT04363684Tofersen in Non-SOD1 ALS
- Massachusetts General Hospital, Boston
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jun 25, 2026 · NCT07294144Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia
- Massachusetts General Hospital, Boston
Recruiting
Ages 18 to 80 · All sexes · Updated Jun 2, 2026 · NCT05724173BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia
- Massachusetts General Hospital, Boston
Recruiting
Ages 18 to 80 · All sexes · Updated Jun 1, 2026 · NCT00912041ALS/MND Natural History Study Data Repository
- Lahey Clinic, Burlington
RecruitingObservational study
Ages 18 to 90 · All sexes · Updated May 20, 2026 · NCT05966038EIM Via the Myolex mScan as an ALS Biomarker
- Massachusetts General Hospital, Boston
- Beth Israel Deaconess Medical Center, Boston
RecruitingObservational study
Ages 18 and older · All sexes · Updated Apr 22, 2026 · NCT06491732Connect-One: Early Feasibility Study of Connexus® Brain-Computer Interface (BCI)
- Massachusetts General Hospital, Boston
Recruiting
Ages 22 to 75 · All sexes · Updated Apr 14, 2026 · NCT07357428AMX0114 in Adult Participants With Amyotrophic Lateral Sclerosis
- Massachusetts General Hospital, Healey & AMG Center for ALS, Boston
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Apr 14, 2026 · NCT06665165A Study to Learn More About the Long-Term Safety of Tofersen (Qalsody) in Participants With Superoxide Dismutase 1 (SOD-1) Amyotrophic Lateral Sclerosis (ALS)
- Mass General Hospital -MGH, Boston
RecruitingObservational study
Ages 18 and older · All sexes · Updated Apr 9, 2026 · NCT07259980Intermuscular Coherence as a Biomarker for ALS
- Massachusetts General Hospital, Boston
RecruitingObservational studyHealthy volunteers welcome
Ages 20 to 90 · All sexes · Updated Feb 9, 2026 · NCT05104710Target ALS Biomarker Study; Longitudinal Biofluids, Clinical Measures, and At Home Measures
- Massachusetts General Hospital, Boston
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Nov 21, 2025 · NCT05137665Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS Patients
- Lahey Hospital and Medical Center, Burlington
RecruitingPhase 3
Ages 18 to 81 · All sexes · Updated Sep 12, 2025 · NCT03127267ALS Research Collaborative
- ALS Therapy Development Institute, Watertown
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Mar 20, 2025 · NCT06885918From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.