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Amyotrophic Lateral Sclerosis clinical trials in Boston, MA

19 studies for Amyotrophic Lateral Sclerosis are looking for participants at sites in and around Boston (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Study is to Assess the Safety and Tolerability of VTx-002 in Participants With ALS

RecruitingPhase 1/2
  • Sean M. Healey & AMG Center for ALS at Massachusetts General Hospital, Boston
Ages 18 and older · All sexes · Updated Nov 13, 2026 · NCT07287397

Healey ALS MyMatch Common Screening Protocol

RecruitingObservational study
  • Massachusetts General Hospital, Boston
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT07400393

RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses

RecruitingPhase 2
  • Dana Farber Cancer Institute, Boston
Ages 18 to 80 · All sexes · Updated Nov 10, 2026 · NCT07002034

ASSESS ALL ALS Study

RecruitingObservational studyHealthy volunteers welcome
  • Massachusetts General Brigham, Boston
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT06578195

Pridopidine Phase 3 Study to Evaluate Efficacy and Safety in ALS

RecruitingPhase 3
  • Sean M. Healey & AMG Center for ALS, Boston
Ages 18 to 80 · All sexes · Updated Oct 27, 2026 · NCT07322003

Do Video Recordings of Multidisciplinary Clinics Improve Quality of Life for People With ALS and Their Caregivers?

Recruiting
  • Massachusetts General Hospital, Boston
Ages 18 and older · All sexes · Updated Oct 8, 2026 · NCT07454733

ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

RecruitingObservational studyHealthy volunteers welcome
  • Massachusetts General Hospital, Boston
Ages 18 and older · All sexes · Updated Oct 7, 2026 · NCT04363684

RAPA-501 Therapy for ALS

RecruitingPhase 2/3
  • Massachusetts General Hospital, Boston
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT04220190

Controlling Amyotrophic Lateral Sclerosis Motor Neuron Excitability Study

Recruiting
  • Beth Israel Deaconess Medical Center, Boston
Ages 18 to 80 · All sexes · Updated Sep 10, 2026 · NCT06649955

Usnoflast Neuromuscular Investigation for Treatment Efficacy in Amyotrophic Lateral Sclerosis

RecruitingPhase 2
  • Zydus US010, Boston
Ages 18 and older · All sexes · Updated Sep 1, 2026 · NCT07023835

Tofersen in Non-SOD1 ALS

RecruitingPhase 2
  • Massachusetts General Hospital, Boston
Ages 18 and older · All sexes · Updated Jun 25, 2026 · NCT07294144

Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia

Recruiting
  • Massachusetts General Hospital, Boston
Ages 18 to 80 · All sexes · Updated Jun 2, 2026 · NCT05724173

BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia

Recruiting
  • Massachusetts General Hospital, Boston
Ages 18 to 80 · All sexes · Updated Jun 1, 2026 · NCT00912041

EIM Via the Myolex mScan as an ALS Biomarker

RecruitingObservational study
  • Massachusetts General Hospital, Boston
  • Beth Israel Deaconess Medical Center, Boston
Ages 18 and older · All sexes · Updated Apr 22, 2026 · NCT06491732

Connect-One: Early Feasibility Study of Connexus® Brain-Computer Interface (BCI)

Recruiting
  • Massachusetts General Hospital, Boston
Ages 22 to 75 · All sexes · Updated Apr 14, 2026 · NCT07357428

AMX0114 in Adult Participants With Amyotrophic Lateral Sclerosis

RecruitingPhase 1
  • Massachusetts General Hospital, Healey & AMG Center for ALS, Boston
Ages 18 and older · All sexes · Updated Apr 14, 2026 · NCT06665165

A Study to Learn More About the Long-Term Safety of Tofersen (Qalsody) in Participants With Superoxide Dismutase 1 (SOD-1) Amyotrophic Lateral Sclerosis (ALS)

RecruitingObservational study
  • Mass General Hospital -MGH, Boston
Ages 18 and older · All sexes · Updated Apr 9, 2026 · NCT07259980

Intermuscular Coherence as a Biomarker for ALS

RecruitingObservational studyHealthy volunteers welcome
  • Massachusetts General Hospital, Boston
Ages 20 to 90 · All sexes · Updated Feb 9, 2026 · NCT05104710

Target ALS Biomarker Study; Longitudinal Biofluids, Clinical Measures, and At Home Measures

RecruitingObservational studyHealthy volunteers welcome
  • Massachusetts General Hospital, Boston
Ages 18 and older · All sexes · Updated Nov 21, 2025 · NCT05137665

About Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, is a nerve disease that weakens muscles and gets worse over time. Learn how to manage symptoms.

More about Amyotrophic Lateral Sclerosis on MedlinePlus

Amyotrophic Lateral Sclerosis trials in other cities

Other studies in Boston

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.