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Lung Cancer clinical trials in New Haven, CT

22 studies for Lung Cancer are looking for participants at sites in and around New Haven (within about 30 miles). Open a study to see who can join and how to contact the study team.

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Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

RecruitingPhase 3
  • Yale University, New Haven
  • Veterans Affairs Connecticut Healthcare System-West Haven Campus, West Haven · 3 mi away
  • Yale-New Haven Hospital North Haven Medical Center, North Haven · 7 mi away
  • and 2 more
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT04267848

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

RecruitingPhase 1/2
  • Yale Cancer Center, New Haven
Ages 12 and older · All sexes · Updated Oct 2, 2026 · NCT04585750

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 2
  • Yale Cancer Center, New Haven
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06172478

Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial

RecruitingPhase 3
  • Veterans Affairs Connecticut Healthcare System-West Haven Campus, West Haven · 3 mi away
Ages 70 and older · All sexes · Updated Oct 1, 2026 · NCT06096844

Osimertinib With or Without Bevacizumab as Initial Treatment for Patients With EGFR-Mutant Lung Cancer

RecruitingPhase 3
  • Yale University, New Haven
  • Yale-New Haven Hospital North Haven Medical Center, North Haven · 7 mi away
  • Smilow Cancer Hospital-Derby Care Center, Derby · 8 mi away
  • and 1 more
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT04181060

Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301)

RecruitingPhase 3
  • Yale University, Smillow Cancer Center, New Haven
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT06881784

Phase 1 Study of PF-08046033 in Advanced Solid Tumors

RecruitingPhase 1
  • Smilow Cancer Hospital - Yale New Haven Health, New Haven
  • Yale - New Haven Hospital - Yale Cancer Center, New Haven
  • Smilow Cancer Hospital Phase 1 Unit, New Haven
  • and 1 more
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07519655

Neoadjuvant and Adjuvant Treatment in Resectable Non-small Cell Lung Cancer

RecruitingPhase 2
  • Research Site, New Haven
Ages 18 to 95 · All sexes · Updated Sep 23, 2026 · NCT05061550

Study of RMC-5127 in Patients With Advanced KRAS G12V-Mutant Solid Tumors

RecruitingPhase 1
  • Yale Cancer Center, New Haven
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07349537

Testing the Combination of an Anti-cancer Drug, Iadademstat, With Other Anti-cancer Drugs (Atezolizumab or Durvalumab) at Improving Outcomes for Small Cell Lung Cancer

RecruitingPhase 1/2
  • Yale University, New Haven
  • Yale-New Haven Hospital North Haven Medical Center, North Haven · 7 mi away
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT06287775

Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies

RecruitingPhase 1/2
  • Yale University School of Medicine - Yale Cancer Center, New Haven
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT05786924

A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

RecruitingPhase 3
  • Yale University School of Medicine, New Haven
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT06119581

AVENTINE-1: Study of AVZO-1418 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Solid Tumors (AVZO-1418-1001)

RecruitingPhase 1/2
  • Avenzo Therapeutics Recruiting Site, New Haven
Ages 18 to 75 · All sexes · Updated Sep 4, 2026 · NCT07038343

Open-label Study of BBO-8520 in Adult Subjects With KRASG12C Non-small Cell Lung Cancer

RecruitingPhase 1
  • Yale Cancer Center, New Haven
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT06343402

Study of XmAb®819 in Subjects With Advanced Clear Cell Renal Cell Carcinoma

RecruitingPhase 1
  • Xencor Investigative Site, New Haven
Ages 18 and older · All sexes · Updated Aug 3, 2026 · NCT05433142

A Study of Peluntamig (PT217) in Patients With Neuroendocrine Carcinomas Expressing DLL3 (the SKYBRIDGE Study)

RecruitingPhase 1/2
  • Yale University Cancer Center, New Haven
Ages 18 and older · All sexes · Updated Jul 15, 2026 · NCT05652686

Comparing Combinations of Targeted Drugs for Advanced Non-Small Cell Lung Cancer That Has EGFR and MET Gene Changes (A Lung-MAP Treatment Trial)

RecruitingPhase 2
  • Yale University, New Haven
  • Smilow Cancer Hospital-Orange Care Center, Orange · 5 mi away
  • Yale-New Haven Hospital North Haven Medical Center, North Haven · 7 mi away
  • and 2 more
Ages 18 and older · All sexes · Updated Jun 3, 2026 · NCT05642572

Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors

RecruitingPhase 1
  • Smilow Cancer Hospital (Yale University), New Haven
Ages 18 and older · All sexes · Updated Jun 3, 2026 · NCT06040541

Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has a MET Exon 14 Skipping Gene Change (An Expanded Lung-MAP Treatment Trial)

RecruitingPhase 2
  • Yale University, New Haven
  • Yale-New Haven Hospital North Haven Medical Center, North Haven · 7 mi away
  • Smilow Cancer Hospital-Derby Care Center, Derby · 8 mi away
  • and 1 more
18 Minutes · All sexes · Updated May 5, 2026 · NCT06031688

Adding the Immunotherapy Drug Cemiplimab to Usual Treatment for People With Advanced Non-Small Cell Lung Cancer Who Had Previous Treatment With Platinum Chemotherapy and Immunotherapy (An Expanded Lung-MAP Treatment Trial)

RecruitingPhase 2/3
  • Yale University, New Haven
  • Yale-New Haven Hospital North Haven Medical Center, North Haven · 7 mi away
  • Smilow Cancer Hospital-Derby Care Center, Derby · 8 mi away
  • and 1 more
Ages 18 and older · All sexes · Updated May 5, 2026 · NCT06616584

Telephone-based Physical Activity Coaching or Self Monitored Physical Activity to Improve Physical Function in Older Adults Who Are Undergoing Surgery for Lung Cancer and Their Caregivers

RecruitingHealthy volunteers welcome
  • Yale New Haven Medical Center, New Haven
Ages 18 and older · All sexes · Updated Mar 5, 2026 · NCT06196008

The Natural History and Biological Study of Pulmonary Recurrent Respiratory Papillomatosis (pRRP)

RecruitingObservational study
  • Yale School of Medicine, New Haven
Ages 18 to 99 · All sexes · Updated Aug 12, 2025 · NCT06412172

About Lung Cancer

Lung cancer forms in tissues of the lung, usually in the cells that line the air passages. It is the leading cause of cancer death in both men and women.

More about Lung Cancer on MedlinePlus

Lung Cancer trials in other cities

Other studies in New Haven

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.