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Lung Cancer clinical trials in Philadelphia, PA
36 studies for Lung Cancer are looking for participants at sites in and around Philadelphia (within about 30 miles). Open a study to see who can join and how to contact the study team.
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Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial
RecruitingPhase 3
- ECOG-ACRIN Cancer Research Group, Philadelphia
- Lankenau Medical Center, Wynnewood · 7 mi away
- Riddle Memorial Hospital, Media · 12 mi away
- and 2 more
Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])
RecruitingPhase 3
- Thomas Jefferson University Hospital, Philadelphia
- Fox Chase Cancer Center, Philadelphia
- Temple University Hospital, Philadelphia
- and 5 more
Osimertinib With or Without Bevacizumab as Initial Treatment for Patients With EGFR-Mutant Lung Cancer
RecruitingPhase 3
- Fox Chase Cancer Center, Philadelphia
- Lankenau Medical Center, Wynnewood · 7 mi away
- Riddle Memorial Hospital, Media · 12 mi away
- and 1 more
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
RecruitingPhase 1/2
- Abramson Cancer Center of the University of Pennsylvania, Philadelphia
Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
RecruitingObservational studyHealthy volunteers welcome
- Reading Hospital McGlinn Cancer Institute at Phoenixville, Phoenixville · 22 mi away
Empathic Communication Skills (ECS) Training
RecruitingHealthy volunteers welcome
- University of Pennsylvania (Data Collection Only), Philadelphia
- Fox Chase Cancer Center (Data Collection Only), Philadelphia
Immunotherapy After Surgery for People Who Have No Remaining Cancer Cells After Standard Treatment for Early-Stage Non-Small Cell Lung Cancer, INSIGHT Trial
RecruitingPhase 3
- Thomas Jefferson University Hospital, Philadelphia
- Jefferson Torresdale Hospital, Philadelphia
- Lankenau Medical Center, Wynnewood · 7 mi away
- and 2 more
A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)
RecruitingPhase 3
- Alliance Cancer Specialists - Media, Media · 12 mi away
A Registry for People With Lung Cancer
RecruitingObservational study
- Thomas Jefferson University Hospital (Data Collection Only), Philadelphia
Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)
RecruitingPhase 2/3
- Hospital of the University of Pennsylvania, Philadelphia
A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer
RecruitingPhase 3
- Thomas Jefferson University, Sidney Kimmel Cancer Center - Clinical Trials Office, Philadelphia
- USO - Alliance Cancer Specialists, PC, Horsham · 16 mi away
AVENTINE-1: Study of AVZO-1418 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Solid Tumors (AVZO-1418-1001)
RecruitingPhase 1/2
- Avenzo Therapeutics Recruiting Site, Philadelphia
Study to Evaluate Efficacy and Safety of Firmonertinib Compared With Investigator's Choice of EGFR Inhibitor as First-Line Treatment in Participants Who Have Locally Advanced or Metastatic NSCLC With EGFR P-Loop and Alpha C-Helix Compressing (PACC) Uncommon Mutations
RecruitingPhase 3
- Fox Chase Cancer Center, Philadelphia
Evaluation of the Safety and Efficacy of Abenacianine (VGT-309) to Identify Cancer in Subjects Undergoing Surgery for Cancer in the Lung
RecruitingPhase 3
- Hospital of the University of Pennsylvania, Philadelphia
Pemefolacianine for IMI of Lung Cancer
RecruitingPhase 1
- University of Pennsylvania, Philadelphia
A Study of Pembrolizumab With or Without Chemotherapy in Combination With Additional Treatments for Advanced Non-Small Cell Lung Cancer (NSCLC) (MK-3475-01G/KEYMAKER U01)
RecruitingPhase 2
- Abramson Cancer Center ( Site 0010), Philadelphia
Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-Small Cell Lung Cancer
RecruitingPhase 3
- University of Pennsylvania/Abramson Cancer Center, Philadelphia
- Thomas Jefferson University Hospital, Philadelphia
- Fox Chase Cancer Center, Philadelphia
- and 5 more
A Phase 1 Dose-escalation Trial of KST-6051 in Participants With Advanced Solid Tumors With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Mutation
RecruitingPhase 1
- Sidney Kimmel Cancer Center, Philadelphia
MOv19-BBz CAR T Cells in FRa+ Cancers
RecruitingPhase 1
- University of Pennsylvania, Philadelphia
Comparing Combinations of Targeted Drugs for Advanced Non-Small Cell Lung Cancer That Has EGFR and MET Gene Changes (A Lung-MAP Treatment Trial)
RecruitingPhase 2
- UPMC Hillman Cancer Center - Part of Frick Hospital, Mount Pleasant · 8 mi away
Assessment of a Radiomics-based Computer-Aided Diagnosis Tool for Pulmonary nodulES
Recruiting
- Penn Medicine University City, Philadelphia
- Perelman Center for Advanced Medicine, Philadelphia
- Penn Medicine Washington Square, Philadelphia
Support and Outreach to Increase Screening for Lung Cancer in Patients With a History of Smoking
RecruitingHealthy volunteers welcome
- Sidney Kimmel Cancer Center at Thomas Jefferson University, Philadelphia
Telehealth Collaborative Care Model (CoCM) in Lung Cancer
Recruiting
- Abramson Cancer Center at the University of Pennsylvania, Philadelphia
Dose Attenuated Chemotherapy in Compromised Patients With Lung Cancer
RecruitingPhase 2
- Fox Chase Cancer Center, Philadelphia
Adding the Immunotherapy Drug Cemiplimab to Usual Treatment for People With Advanced Non-Small Cell Lung Cancer Who Had Previous Treatment With Platinum Chemotherapy and Immunotherapy (An Expanded Lung-MAP Treatment Trial)
RecruitingPhase 2/3
- Fox Chase Cancer Center, Philadelphia
- Temple University Hospital, Philadelphia
- UPMC Hillman Cancer Center - Part of Frick Hospital, Mount Pleasant · 8 mi away
A Study of LP-300 With Carboplatin and Pemetrexed in Never Smokers With Advanced Lung Adenocarcinoma
RecruitingPhase 2
- Fox Chase Cancer Center, Philadelphia
A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors
RecruitingPhase 1/2
- Univ of Pennsylvania, Abramson Cancer Center, Philadelphia
Efficacy and Safety of a Single Dose of LS301-IT for Fluorescence Intraoperative Molecular Imaging (IMI) for Patients Undergoing Lung Cancer Resection for Non Small Cell Lung Cancer
RecruitingPhase 2
- University of Pennsylvania, Philadelphia
A Phase 1 Study of CPO301 in Adult Patients With Advanced or Metastatic Solid Tumors
RecruitingPhase 1
- Fox Chase Cancer Center, Philadelphia
A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors
RecruitingPhase 1/2
- University of Pennsylvania, Philadelphia
A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation
RecruitingPhase 1
- Thomas Jefferson University, Sidney Kimmel Cancer Center, Philadelphia
- Fox Chase Cancer Center, Philadelphia
PET/CT Imaging to Evaluate Cardiac Radiation Damage in Patients With Lung or Esophageal Cancer, EUCLID Trial
Recruiting
- Thomas Jefferson University Hospital, Philadelphia
The Impact of Surgical Technique on Circulating Tumor DNA in Stage I-III Non-Small Cell Lung Cancer
Recruiting
- Jefferson Health Northeast, Philadelphia
- Thomas Jefferson University Hospital, Philadelphia
- Abington Memorial Hospital, Abington · 12 mi away
- and 1 more
LOTUS-CC: An Observational Research Study to Uncover Subtypes of Cancer Cachexia
RecruitingObservational study
- Christiana Care Health System-Wilmington Hospital, Wilmington · 25 mi away
SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
RecruitingObservational study
- Massive Bio SYNERGY-AI site, Philadelphia
Clinical Validation of Freenome Multiomics Blood Test for Lung Cancer Screening
RecruitingObservational study
- Temple University, Philadelphia
About Lung Cancer
Lung cancer forms in tissues of the lung, usually in the cells that line the air passages. It is the leading cause of cancer death in both men and women.
More about Lung Cancer on MedlinePlus
Lung Cancer trials in other cities
- Houston, TX78 studies
- Boston, MA62 studies
- New York City, NY60 studies
- Los Angeles, CA45 studies
- Arlington, VA41 studies
- Washington, DC41 studies
- Chicago, IL41 studies
- Baltimore, MD40 studies
- Nashville, TN40 studies
- St. Louis, MO39 studies
- Columbus, OH37 studies
- Seattle, WA33 studies
Other studies in Philadelphia
- Cancer (all types)59 studies
- Breast Cancer56 studies
- Non-Small Cell Lung Cancer51 studies
- Metastatic Cancer46 studies
- Prostate Cancer44 studies
- Colorectal Cancer44 studies
- Ovarian Cancer44 studies
- Acute Myeloid Leukemia34 studies
- Heart Failure31 studies
- Endometrial Cancer28 studies
- Depression26 studies
- Pancreatic Cancer26 studies
From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.