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Melanoma clinical trials in Tampa, FL

19 studies for Melanoma are looking for participants at sites in and around Tampa (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa
Ages 40 to 75 · All sexes · Updated Oct 2, 2026 · NCT05334069

A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma (Harmony Head-to-Head)

RecruitingPhase 3
  • H. Lee Moffitt Cancer Center, Tampa
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06246916

Adjuvant Therapy Based on Pathologic Response After Neoadjuvant Encorafenib Binimetinib in Melanoma

RecruitingEarly phase 1
  • Moffitt Cancer Center, Tampa
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT04741997

A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases

RecruitingPhase 2
  • Moffitt Cancer Center-International Plaza, Tampa
  • Moffitt Cancer Center - McKinley Campus, Tampa
  • Moffitt Cancer Center, Tampa
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT04511013

Project: Every Child for Younger Patients With Cancer

RecruitingObservational study
  • Tampa General Hospital, Tampa
  • Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa
Up to age 25 · All sexes · Updated Aug 25, 2026 · NCT02402244

Clinical Trial of CD40L-augmented TIL for Patients With Advanced Melanoma

RecruitingPhase 1/2
  • Moffitt Cancer Center, Tampa
Ages 18 and older · All sexes · Updated Jun 26, 2026 · NCT06961357

MEM-288 Oncolytic Virus Alone and in Combination With Standard of Care Therapy in Advanced Solid Tumors

RecruitingPhase 1
  • Moffitt Cancer Center, Tampa
Ages 18 and older · All sexes · Updated Jun 11, 2026 · NCT05076760

Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS

RecruitingPhase 1/2
  • Moffitt Cancer Center, Tampa
Ages 18 and older · All sexes · Updated May 15, 2026 · NCT05379985

Neoadjuvant Darovasertib in Primary Uveal Melanoma

RecruitingPhase 3
  • USF Health Eye Institute, Tampa
  • Moffit Cancer Center, Tampa
Ages 18 and older · All sexes · Updated May 6, 2026 · NCT07015190

A Trial of LNS8801 With or Without Pembrolizumab in Patients With Refractory Melanoma

RecruitingPhase 2/3
  • Moffitt Cancer Center, Tampa
Ages 18 and older · All sexes · Updated Apr 22, 2026 · NCT06624644

A Study to Investigate the Safety and Efficacy of NST-628 Oral Tablets in Subjects With Solid Tumors

RecruitingPhase 1
  • Moffitt Cancer Center, Tampa
Ages 18 and older · All sexes · Updated Apr 20, 2026 · NCT06326411

Neoadjuvant and Adjuvant Anti-PD1 or Combinations for Locoregionally Advanced Melanoma

RecruitingPhase 2
  • Moffitt Cancer Center, Tampa
Ages 18 and older · All sexes · Updated Apr 1, 2026 · NCT06295159

Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics

RecruitingObservational study
  • Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa
Ages 18 and older · All sexes · Updated Mar 17, 2026 · NCT06418204

Efficacy of Daromun Neoadjuvant Intratumoral Treatment in Clinical Stage IIIB/C/D Melanoma Patients

RecruitingPhase 3
  • Moffitt Cancer Center, Tampa
Ages 18 and older · All sexes · Updated Dec 17, 2025 · NCT03567889

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Tampa
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma

Recruiting
  • Moffitt Cancer Center - McKinley Campus, Tampa
  • Moffitt Cancer Center, Magnolia Campus, Tampa
Ages 18 and older · All sexes · Updated Nov 27, 2024 · NCT03860883

Phase 1a and Phase 2 Study for Safety, Preliminary Efficacy, PK and PD of ST-067

RecruitingPhase 1/2
  • Moffitt Cancer Center, Tampa
Ages 18 and older · All sexes · Updated Nov 15, 2024 · NCT04787042

About Melanoma

Melanoma is the most serious type of skin cancer. Most have a black or black-blue area. Learn the 'ABCDE' of what to watch for and treatment options.

More about Melanoma on MedlinePlus

Melanoma trials in other cities

Other studies in Tampa

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.