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Metastatic Cancer clinical trials in Lexington, KY

11 studies for Metastatic Cancer are looking for participants at sites in and around Lexington (within about 30 miles). Open a study to see who can join and how to contact the study team.

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Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

RecruitingPhase 2
  • CommonSpirit Saint Joseph Medical Center - East Lexington, Lexington
  • University of Kentucky/Markey Cancer Center, Lexington
All ages · All sexes · Updated Oct 5, 2026 · NCT05564377

Testing the Safety and Tolerability of the Anti-cancer Drugs Trastuzumab Deruxtecan and Neratinib for Cancers With Changes in the HER2 Gene

RecruitingPhase 1
  • University of Kentucky/Markey Cancer Center, Lexington
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT05372614

Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors

RecruitingPhase 2/3
  • University of Kentucky Markey Cancer Center, Lexington
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT06943755

Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer

RecruitingPhase 3
  • Baptist Health Lexington, Lexington
  • Baptist Health Richmond, Lexington
  • Baptist Health Hamburg, Lexington
  • and 3 more
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07222800

A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue

RecruitingPhase 2/3
  • University of Kentucky Research Foundation, Lexington
  • University of Kentucky Healthcare - Markey Cancer Center, Lexington
  • University of Kentucky Medical Center, Lexington
  • and 1 more
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06989437

A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer

RecruitingPhase 3
  • Baptist Health Lexington, Lexington
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07213804

A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

RecruitingPhase 3
  • CHI Saint Joseph Cancer Center - East, Lexington
  • University of Kentucky Chandler Medical Center, Lexington
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT06119581

Personalized Antibody-Drug Conjugate Therapy Based on RNA and Protein Testing for the Treatment of Advanced or Metastatic Solid Tumors (The ADC MATCH Screening and Treatment Trial)

RecruitingPhase 2
  • University of Kentucky/Markey Cancer Center, Lexington
Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT06311214

A Study to Investigate Safety and Effectiveness of CRN09682 in Participants With SST2-Expressing NENs and Other Solid Tumors

RecruitingPhase 1/2
  • Crinetics Study Site, Lexington
Ages 18 and older · All sexes · Updated Jul 31, 2026 · NCT07129252

Safety and Tolerability of ²¹²Pb-DOTAM-GRPR1 in Adult Subjects With Recurrent or Metastatic GRPR-expressing Tumors

RecruitingPhase 1
  • UK Markey Cancer Center, Lexington
Ages 18 and older · All sexes · Updated Jun 11, 2026 · NCT05283330

A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

RecruitingPhase 1
  • University of Kentucky Markey Cancer Center, Lexington
Ages 18 and older · All sexes · Updated Feb 13, 2026 · NCT06778863

Metastatic Cancer trials in other cities

Other studies in Lexington

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.