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Ovarian Cancer clinical trials in Sioux Falls, SD

16 studies for Ovarian Cancer are looking for participants at sites in and around Sioux Falls (within about 30 miles). Open a study to see who can join and how to contact the study team.

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Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

RecruitingPhase 2
  • Sanford Cancer Center Oncology Clinic, Sioux Falls
  • Sanford USD Medical Center - Sioux Falls, Sioux Falls
All ages · All sexes · Updated Oct 5, 2026 · NCT05564377

A Phase 1 Study of PLN-101095 in Adults With Advanced or Metastatic Solid Tumors

RecruitingPhase 1
  • Avera Medical Group, Sioux Falls
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06270706

A Study to Assess Anti-Tumor Activity of Intravenously (IV) Infused Carboplatin With Mirvetuximab Soravtansine in Participants With Newly Diagnosed Folate Receptor Alpha (FRα)Expressing Advanced-Stage Serous Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer.

RecruitingPhase 2
  • Sanford Cancer Center /ID# 274901, Sioux Falls
  • Avera Cancer Institute - Sioux Falls /ID# 276226, Sioux Falls
Ages 18 and older · Women · Updated Sep 29, 2026 · NCT06890338

A Study of Azenosertib (ZN-c3) in Subjects With Platinum-Resistant High-Grade Serous Ovarian, Fallopian Tube or Primary Peritoneal Cancer

RecruitingPhase 2
  • Site 0132 - Avera Cancer Institute, Sioux Falls
Ages 18 and older · Women · Updated Sep 29, 2026 · NCT05128825

A Study to Assess Adverse Events and Change in Disease Activity of Multiple Treatment Combinations With Intravenous Mirvetuximab Soravtansine in Adult Participants With Ovarian Cancer

RecruitingPhase 2
  • Avera Cancer Institute - Sioux Falls /ID# 278627, Sioux Falls
Ages 18 and older · Women · Updated Sep 22, 2026 · NCT07059845

Study to Evaluate INCB123667 Versus Investigator's Choice of Chemotherapy in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression

RecruitingPhase 3
  • Sanford Cancer Center-Sioux Falls, Sioux Falls
Ages 18 and older · Women · Updated Sep 15, 2026 · NCT07214779

Investigation of Ubamatamab Combination Therapy in Adult Participants With Platinum-Resistant Ovarian Cancer

RecruitingPhase 2
  • Avera Cancer Institute Sioux Falls, Sioux Falls
Ages 18 and older · Women · Updated Sep 14, 2026 · NCT06787612

A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer

Recruiting
  • Sanford Cancer Center Oncology Clinic, Sioux Falls
  • Sanford USD Medical Center - Sioux Falls, Sioux Falls
Ages 35 to 50 · Women · Updated Aug 7, 2026 · NCT04251052

Testing Olaparib for One or Two Years, With or Without Bevacizumab, to Treat Ovarian Cancer

RecruitingPhase 3
  • Sanford Cancer Center Oncology Clinic, Sioux Falls
  • Avera Cancer Institute, Sioux Falls
  • Sanford USD Medical Center - Sioux Falls, Sioux Falls
Ages 18 and older · All sexes · Updated Aug 7, 2026 · NCT06580314

A Study of Raludotatug Deruxtecan (R-DXd) in Subjects With Platinum-resistant, High-grade Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

RecruitingPhase 2/3
  • Sanford Cancer Center Gynecologic Oncology, Sioux Falls
Ages 18 and older · All sexes · Updated Jul 28, 2026 · NCT06161025

A Study of Sigvotatug Vedotin in Advanced Solid Tumors

RecruitingPhase 1
  • Sanford Cancer Center, Sioux Falls
  • Sanford USD Medical Center, Sioux Falls
Ages 18 and older · All sexes · Updated Jul 6, 2026 · NCT04389632

Study of Trastuzumab Deruxtecan With Bevacizumab Versus Bevacizumab Monotherapy for First-line Maintenance in HER2-Expressing Ovarian Cancer (DESTINY-Ovarian01)

RecruitingPhase 3
  • Avera Medical Group Gynecologic, Sioux Falls
Ages 18 and older · Women · Updated Jul 2, 2026 · NCT06819007

A Study of Emiltatug Ledadotin (Emi-Le) in Participants With Solid Tumors

RecruitingPhase 1/2
  • Avera Cancer Institute, Sioux Falls
Ages 18 and older · All sexes · Updated Jun 29, 2026 · NCT05377996

Avera Cancer Sequencing and Analytics Protocol (ASAP)

RecruitingObservational study
  • Avera Cancer Institute, Sioux Falls
Ages 18 and older · All sexes · Updated Mar 27, 2026 · NCT05142033

About Ovarian Cancer

Ovarian cancer is a cancerous tumor that forms in the tissues of an ovary. The ovaries are a pair of female reproductive glands that make eggs and female hormones.

More about Ovarian Cancer on MedlinePlus

Ovarian Cancer trials in other cities

Other studies in Sioux Falls

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.