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Triple-Negative Breast Cancer clinical trials in Chicago, IL

16 studies for Triple-Negative Breast Cancer are looking for participants at sites in and around Chicago (within about 30 miles). Open a study to see who can join and how to contact the study team.

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A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors

RecruitingPhase 1
  • University of Chicago Hospital, Chicago
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06465069

PRE-ISPY Phase I/II Oncology Platform Program

RecruitingPhase 1/2
  • The University of Chicago Medicine Comprehensive Cancer Center, Chicago
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT05868226

A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Triple-Negative Breast Cancer (MK-2870-011/TroFuse-011)

RecruitingPhase 3
  • University of Illinois Cancer Center ( Site 0044), Chicago
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06841354

Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors

RecruitingPhase 1
  • Northwestern University Feinberg School of Medicine, Chicago
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT05983432

Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)

RecruitingPhase 3
  • Northwestern Medicine, Chicago
  • Rush University Medical Center, Chicago
  • University of Chicago Medical Center, Chicago
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT05633654

SMP-3124LP in Adults With Advanced Solid Tumors

RecruitingPhase 1/2
  • Northwestern Medicine Cancer Center, Chicago
  • The University of Chicago, Chicago
Ages 18 and older · All sexes · Updated Aug 12, 2026 · NCT06526819

A Study of Emiltatug Ledadotin (Emi-Le) in Participants With Solid Tumors

RecruitingPhase 1/2
  • Northwestern University, Chicago
Ages 18 and older · All sexes · Updated Jun 29, 2026 · NCT05377996

Study to Assess Adverse Events and Pharmacokinetics in Adult Participants With Non-Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma and Other Solid Tumors, Receiving Intravenous Infusion of Azirkitug Alone or in Combination(s) With Budigalimab, Bevacizumab, or Telisotuzumab Adizutecan

RecruitingPhase 1
  • University of Illinois Hospital and Health Sciences System /ID# 251750, Chicago
  • University of Chicago Medical Center /ID# 276271, Chicago
Ages 18 and older · All sexes · Updated Jun 23, 2026 · NCT05005403

A Study of LY4175408 in Participants With Advanced Cancer

RecruitingPhase 1
  • The University of Chicago Medical Center (UCMC), Chicago
Ages 18 and older · All sexes · Updated Jun 23, 2026 · NCT07046923

Study of XB010 in Subjects With Solid Tumors

RecruitingPhase 1
  • University of Chicago Medical Center, Chicago
Ages 18 and older · All sexes · Updated Jun 22, 2026 · NCT06545331

I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer

RecruitingPhase 2
  • University of Chicago, Chicago
Ages 18 and older · All sexes · Updated May 6, 2026 · NCT01042379

Sacituzumab Govitecan +/- Pembrolizumab in Metastatic TNBC

RecruitingPhase 2
  • University of Chicago Medical Center, Chicago
Ages 18 and older · All sexes · Updated Apr 29, 2026 · NCT04468061

A Dose Randomization Study of Bulumtatug Fuvedotin in TNBC Patients Previously Treated With ADCs

RecruitingPhase 1
  • UChicago Medicine Comprehensive Cancer Center, Chicago
Ages 18 and older · All sexes · Updated Mar 17, 2026 · NCT06908928

A Study of NX-1607 in Adults With Advanced Malignancies

RecruitingPhase 1
  • University of Chicago, Chicago
Ages 18 and older · All sexes · Updated Sep 9, 2025 · NCT05107674

Triple-Negative Breast Cancer trials in other cities

Other studies in Chicago

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.