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Heart Failure clinical trials in Chicago, IL

32 studies for Heart Failure are looking for participants at sites in and around Chicago (within about 30 miles). Open a study to see who can join and how to contact the study team.

A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF

RecruitingPhase 3
  • Research Site, Chicago
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07761117

A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure

RecruitingPhase 3
  • Illinois Masonic Hospital, Chicago
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06424288

A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart

RecruitingPhase 3
  • Illinois Masonic Hospital, Chicago
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06935370

Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin

RecruitingPhase 3
  • Research Site, Chicago
  • Research Site, Chicago
  • Research Site, Chicago
Ages 40 and older · All sexes · Updated Sep 15, 2026 · NCT06677060

Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function

RecruitingPhase 3
  • Research Site, Chicago
Ages 18 to 130 · All sexes · Updated Sep 11, 2026 · NCT06307652

A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients

RecruitingPhase 3
  • Chicago, IL Investigative Site 10062, Chicago
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT06008197

Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure

Recruiting
  • Advocate Christ Medical Center, Chicago
  • Northwestern University, Chicago
  • University of Chicago, Chicago
Ages 18 to 100 · All sexes · Updated Sep 9, 2026 · NCT06310031

Retinal Fundus Imaging and OCT Imaging for Ocular Detection of ATTR-CM

RecruitingObservational study
  • Research Site, Chicago
Ages 18 and older · All sexes · Updated Aug 26, 2026 · NCT07690436

Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure

Recruiting
  • University of Chicago, Chicago
  • Advocate IMMC, Chicago
Ages 21 and older · All sexes · Updated Aug 25, 2026 · NCT05677100

Optimal Pediatric Heart Transplant Immunosuppression With MicroRNAs

RecruitingObservational study
  • Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago
Up to age 18 · All sexes · Updated Aug 25, 2026 · NCT06532890

LEVEL-2: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF-2

RecruitingPhase 3
  • Tenax Investigational Site, Chicago
  • Tenax Investigational Site, Chicago
Ages 18 to 85 · All sexes · Updated Aug 19, 2026 · NCT07288398

A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity

RecruitingPhase 3
  • Chicago Clinical Research Institute INC, Chicago
  • Univer Of Illinois at Chicago, Chicago
  • Eagle Clinical Research, Chicago
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT07567001

Study of the Progression of Chronic Cardiovascular Conditions

RecruitingObservational study
  • Prolaio, Chicago
Ages 18 and older · All sexes · Updated Aug 12, 2026 · NCT07420907

Cardiac Power Output in Cardiogenic Shock Patients

RecruitingEarly phase 1
  • The University of Chicago, Chicago
Ages 18 and older · All sexes · Updated Aug 6, 2026 · NCT05700617

ELEVATE-HFpEF Clinical Study

Recruiting
  • The University of Chicago Medical Center, Chicago
Ages 40 and older · All sexes · Updated Aug 3, 2026 · NCT06678841

Implementation and Interaction of Clinician And Patient-facing Tools Aiming to Intensify Neurohormonal Medicines for Heart Failure

Recruiting
  • Northwestern University, Chicago
Ages 18 and older · All sexes · Updated Jul 13, 2026 · NCT06526988

Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure

Recruiting
  • University of Chicago, Chicago
Ages 18 and older · All sexes · Updated Jun 10, 2026 · NCT06526195

A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)

RecruitingPhase 2
  • NMH Clinical Research Unit, Chicago
  • Northwestern Memorial HealthCare - Arkes Pavilion, Chicago
  • Northwestern Memorial HealthCare - Feinberg Pavilion, Chicago
  • and 2 more
Ages 18 to 79 · All sexes · Updated May 27, 2026 · NCT06991257

Ultra-High Frequency - Electrocardiogram (UHF-ECG) for the Diagnosis of Ventricular Electrical Dyssynchrony (VED)

RecruitingObservational study
  • University of Chicago, Chicago
Ages 18 and older · All sexes · Updated May 5, 2026 · NCT06641362

HeartShare: Combining Omics, Deep Phenotyping, and Electronic Health Records for Heart Failure Subtypes and Treatment Targets

RecruitingObservational studyHealthy volunteers welcome
  • Northwestern University, Chicago
Ages 30 and older · All sexes · Updated Apr 13, 2026 · NCT05873634

Myocardial Mechanisms in Heart Failure With Preserved Ejection Fraction

RecruitingObservational studyHealthy volunteers welcome
  • Northwestern University, Chicago
Ages 30 and older · All sexes · Updated Apr 9, 2026 · NCT06517186

Sotagliflozin to Slow Kidney Function Decline in Persons With Type 1 Diabetes and Diabetic Kidney Disease

RecruitingPhase 3
  • Northwestern University Feinberg School of Medicine, Chicago
Ages 18 to 75 · All sexes · Updated Mar 24, 2026 · NCT06217302

Sensor-based Congestion ALert for Events in Peritoneal Dialysis (SCALE-PD)

RecruitingObservational study
  • Northwestern University, Chicago
Ages 21 and older · All sexes · Updated Mar 18, 2026 · NCT07059962

XVIVO Heart Box (XHB) With Supplemented XVIVO Heart Solution (SXHS) Continued Access Protocol (CAP)

Recruiting
  • Northwestern Memorial Hospital, Chicago
Ages 18 and older · All sexes · Updated Mar 18, 2026 · NCT06895070

His-Bundle Corrective Pacing in Heart Failure

Recruiting
  • Northwestern Memorial Hospital, Chicago
  • Rush University Medical Center, Chicago
  • University of Chicago, Chicago
Ages 18 and older · All sexes · Updated Feb 9, 2026 · NCT05265520

iCardia4HF: Multi-component mHealth Intervention for Patients With Heart Failure

Recruiting
  • Rush University Medical Center, Chicago
  • University of Illinois Hospital & Health Sciences System, Chicago
Ages 18 and older · All sexes · Updated Jan 30, 2026 · NCT06205225

Human/Machine Interface: What the HeartMate 3 ® Device Tells Us About the Future

RecruitingObservational study
  • University of Chicago, Chicago
Ages 18 to 100 · All sexes · Updated Dec 16, 2025 · NCT06039176

Left vs Left Randomized Clinical Trial

Recruiting
  • Rush University, Chicago
  • University of Chicago, Chicago
Ages 18 and older · All sexes · Updated Oct 2, 2025 · NCT05650658

UIC Multi-Ethnic DCM Registry

RecruitingObservational studyHealthy volunteers welcome
  • University of Illinois Hospital & Health Sciences, Chicago
Ages 18 and older · All sexes · Updated Aug 28, 2025 · NCT07145138

Cardiogenic Shock Working Group Registry

RecruitingObservational study
  • Northwestern Medicine, Chicago
  • University of Chicago, Chicago
Ages 18 and older · All sexes · Updated Jun 6, 2025 · NCT04682483

AN INTERNATIONAL, OBSERVATIONAL, BLINDED STUDY TO ASSESS THE PERFORMANCE OF THE CORDIO HEARO SYSTEM

RecruitingObservational study
  • University of Chicago, Chicago
  • Advocate Illinois Masonic Medical Center, Chicago
Ages 22 and older · All sexes · Updated Mar 26, 2025 · NCT06378632

About Heart Failure

Heart failure, or congestive heart failure (CHF), means the heart can't pump enough blood. Learn about the signs, symptoms, and causes.

More about Heart Failure on MedlinePlus

Heart Failure trials in other cities

Other studies in Chicago

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.