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Oral Cancer clinical trials in St. Louis, MO

8 studies for Oral Cancer are looking for participants at sites in and around St. Louis (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Testing the Addition of Chemotherapy or Chemo-Immunotherapy to the Usual Surgery for Advanced Head and Neck Cancer

RecruitingPhase 2
  • Washington University School of Medicine, St Louis
  • Siteman Cancer Center-South County, St Louis
  • Siteman Cancer Center at Christian Hospital, St Louis
  • and 2 more
Ages 18 and older · All sexes · Updated Oct 5, 2026 · NCT07195734

Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment

RecruitingPhase 3
  • Washington University School of Medicine, St Louis
  • Mercy Hospital South, St Louis
  • Siteman Cancer Center-South County, St Louis
  • and 4 more
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06589804

BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

RecruitingPhase 2
  • Washington University School of Medicine, St Louis
  • Mercy Hospital South, St Louis
  • Siteman Cancer Center-South County, St Louis
  • and 4 more
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT05136196

Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery

RecruitingPhase 2
  • Mercy Infusion Center - Chippewa, St Louis
  • Mercy Hospital South, St Louis
  • Missouri Baptist Medical Center, St Louis
  • and 4 more
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT02734537

Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancer

RecruitingPhase 2/3
  • SSM Health Saint Louis University Hospital, St Louis
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT04333537

Comparing Radiation Plus Cetuximab to Radiation Plus Chemotherapy in People With Head and Neck Cancer Who Cannot Receive Cisplatin

RecruitingPhase 3
  • Cancer Care Center of O'Fallon, O'Fallon · 16 mi away
  • HSHS Saint Elizabeth's Hospital, O'Fallon · 16 mi away
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT07441681

Multi-Site Trial of Navigation vs Treatment as Usual to Improve Initiation of Timely Adjuvant Therapy

Recruiting
  • Washington University in St. Louis, St Louis
Ages 18 and older · All sexes · Updated Dec 11, 2025 · NCT05793151

Validity of Viome's Oral/throat Cancer Test

RecruitingObservational study
  • Missouri School of Dentistry & Oral Health, St Louis
Ages 18 and older · All sexes · Updated Jan 29, 2025 · NCT06174428

About Oral Cancer

Oral cancer can form in the mouth or throat but usually begins in the tongue and floor of the mouth. Read about the common oral cancer symptoms.

More about Oral Cancer on MedlinePlus

Oral Cancer trials in other cities

Other studies in St. Louis

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.