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Treatment-Resistant Depressive Disorder clinical trials in Houston, TX

6 studies for Treatment-Resistant Depressive Disorder are looking for participants at sites in and around Houston (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response

RecruitingPhase 2
  • Baylor College of Medicine, Houston
Ages 18 to 65 · All sexes · Updated Oct 5, 2026 · NCT07284667

Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depression

RecruitingPhase 1Healthy volunteers welcome
  • Wells Medicine, Houston
  • Texas A&M (Houston Methodist Hospital Location), Houston
Ages 21 to 45 · All sexes · Updated Sep 15, 2026 · NCT06480201

Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)

Recruiting
  • CHI St. Luke's Health Baylor College of Medicine Med. Ctr, Houston
  • The Methodist Hospital, Houston
Ages 22 to 70 · All sexes · Updated Aug 28, 2026 · NCT06423430

A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression

Recruiting
  • The University Of Texas Medical School At Houston - UT Center Of Excellence On Mood Disorders, Houston
Ages 18 and older · All sexes · Updated Jun 15, 2026 · NCT03887715

ALTO-207 in Adults With Treatment-resistant Depression (TRD)

RecruitingPhase 2
  • Site 7175, Houston
  • Site 7145, Houston
Ages 18 to 75 · All sexes · Updated Apr 28, 2026 · NCT07553637

Mapping and Modulating the Spatiotemporal Dynamics of Socio-Affective Processing

RecruitingHealthy volunteers welcome
  • Baylor College of Medicine, Houston
Ages 22 to 70 · All sexes · Updated Oct 27, 2025 · NCT05418894

Treatment-Resistant Depressive Disorder trials in other cities

Other studies in Houston

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.