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Chronic Lymphocytic Leukemia clinical trials in Chicago, IL

14 studies for Chronic Lymphocytic Leukemia are looking for participants at sites in and around Chicago (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Testing the Addition of Anti-Cancer Drug Sonrotoclax, to the Standard Treatment Zanubrutinib, for Previously Untreated CLL/SLL

RecruitingPhase 3
  • Northwestern University, Chicago
  • University of Illinois, Chicago
Ages 65 and older · All sexes · Updated Oct 2, 2026 · NCT07321652

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • Mount Sinai Hospital Medical Center, Chicago
  • John H Stroger Jr Hospital of Cook County, Chicago
  • University of Illinois, Chicago
  • and 1 more
Ages 40 to 75 · All sexes · Updated Oct 2, 2026 · NCT05334069

Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study

RecruitingPhase 3
  • Northwestern University, Chicago
  • University of Chicago Comprehensive Cancer Center, Chicago
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT04269902

A Study to Evaluate the Safety and Efficacy of Tacabrutideg (BGB-16673) Compared to Pirtobrutinib in Adults With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

RecruitingPhase 3
  • University of Chicago Medical Center, Chicago
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT06973187

A Phase 1 Study of UB-VV111 With and Without Rapamycin in Relapsed/Refractory CD19+ B-cell Malignancies

RecruitingPhase 1
  • The David and Etta Jonas Center for Cellular Therapy, Chicago
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT06528301

A Study of NX-5948 in Adults With Relapsed/Refractory B-cell Malignancies

RecruitingPhase 1
  • Northwestern University, Chicago
Ages 18 and older · All sexes · Updated Jul 2, 2026 · NCT05131022

Study of Oral Administration of LP-118 in Patients With Relapsed or Refractory CLL, SLL, MDS, MDS/MPN, AML, CMML-2, MPN-BP, ALL, MF, NHL, RT, MM or T-PLL.

RecruitingPhase 1
  • University of Chicago, Chicago
Ages 13 and older · All sexes · Updated May 5, 2026 · NCT04771572

The OPAL Study: AVM0703 for Treatment of Lymphoid Malignancies

RecruitingPhase 1/2
  • University of Illinois at Chicago Cancer Center, Chicago
Ages 12 to 95 · All sexes · Updated Apr 15, 2026 · NCT04329728

A Study of NX-2127 in Adults With Relapsed/Refractory B-cell Malignancies

RecruitingPhase 1
  • The University of Chicago Medical Center, Chicago
Ages 18 and older · All sexes · Updated Mar 20, 2026 · NCT04830137

A Study of (LY3527727) Pirtobrutinib in Participants With Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma or Non-Hodgkin Lymphoma

RecruitingPhase 4
  • Northwestern University, Chicago
Ages 18 and older · All sexes · Updated Mar 2, 2026 · NCT06876662

A Master Protocol to Evaluate the Long-Term Safety of (LY3527727) Pirtobrutinib

RecruitingPhase 4
  • Northwestern University, Chicago
Ages 18 and older · All sexes · Updated Mar 2, 2026 · NCT06876649

AS-1763 in Patients With Previously Treated CLL/SLL or Non-Hodgkin Lymphoma

RecruitingPhase 1
  • Northwestern Memorial Hospital, Chicago
Ages 18 and older · All sexes · Updated Dec 10, 2025 · NCT05602363

Chronic Lymphocytic Leukemia trials in other cities

Other studies in Chicago

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.