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Esophageal Adenocarcinoma clinical trials in Durham, NC

10 studies for Esophageal Adenocarcinoma are looking for participants at sites in and around Durham (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

mFOLFIRINOX Versus mFOLFOX With or Without Nivolumab for the Treatment of Advanced, Unresectable, or Metastatic HER2 Negative Esophageal, Gastroesophageal Junction, and Gastric Adenocarcinoma

RecruitingPhase 3
  • UNC Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
  • University of North Carolina-Hillsborough Campus, Hillsborough · 13 mi away
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT05677490

Upfront Chemotherapy With Radiation Therapy (CRT) Followed by Chemotherapy in Localized Esophageal Adenocarcinoma

RecruitingPhase 2
  • Duke University Medical Center, Durham
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT07603375

Multi-Site Detection of Barrett's Esophagus in Patients Without Chronic GERD Symptoms

RecruitingHealthy volunteers welcome
  • University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
Ages 50 and older · All sexes · Updated Sep 15, 2026 · NCT06687603

Itraconazole in Combination With Ablation for the Prevention of Esophageal Cancer in Patients With High-risk Barrett's Esophagus

RecruitingPhase 2
  • UNC Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT06732388

Surveillance vs. Endoscopic Therapy for Barrett's Esophagus With Low-grade Dysplasia

Recruiting
  • University of North Carolina School of Medicine, Chapel Hill · 10 mi away
Ages 18 to 89 · All sexes · Updated Sep 11, 2026 · NCT05753748

Obeticholic Acid for Prevention in Barrett's Esophagus

RecruitingPhase 2
  • UNC Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Aug 11, 2026 · NCT04939051

Seattle Biopsy Protocol Versus Wide-Area Transepithelial Sampling in Patients With Barrett's Esophagus Undergoing Surveillance

Recruiting
  • University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
Ages 18 to 89 · All sexes · Updated Jul 1, 2026 · NCT05530343

First-in-Human Study of PLX-61639 in Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 1
  • Research Site, Durham
Ages 18 and older · All sexes · Updated Jun 12, 2026 · NCT07284186

A Phase II Trial to Evaluate the Effect of Itraconazole on Pathologic Complete Response Rates in Resectable Esophageal Cancer

RecruitingPhase 2
  • Durham VA Medical Center, Durham, NC, Durham
Ages 18 and older · All sexes · Updated Nov 5, 2025 · NCT05563766

Esophageal Adenocarcinoma trials in other cities

Other studies in Durham

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.