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Ulcerative Colitis clinical trials recruiting in the U.S.

79 studies for Ulcerative Colitis are recruiting participants at sites across the United States.

Ulcerative Colitis (UC) can cause long-lasting swelling and ulcers in the large intestine. It is a type of inflammatory bowel disease. Find out more.

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Recently updated studies

Longitudinal Immunophenotyping of Patients With Inflammatory Bowel Disease

RecruitingObservational study
Ages 18 to 85 · All sexes · Updated Oct 2, 2026 · NCT07619547

Aquamin® for Prevention of Ulcerative Colitis J-Pouch-associate Intestinal Inflammation

RecruitingPhase 2
Ages 18 to 80 · All sexes · Updated Oct 2, 2026 · NCT07501078

A Study of Vedolizumab in Adults With Ulcerative Colitis (UC) or Crohn's Disease (CD) in the Community Setting

RecruitingPhase 4
Ages 18 to 80 · All sexes · Updated Sep 30, 2026 · NCT06581328

A Study to Learn More About How Risankizumab Works in Young Participants With Ulcerative Colitis

RecruitingPhase 3
Ages 2 to 17 · All sexes · Updated Sep 30, 2026 · NCT07071519

Confirmatory Clinical Study in Active Ulcerative Colitis

RecruitingPhase 2
Ages 16 and older · All sexes · Updated Sep 30, 2026 · NCT07296315

A Study of Eltrekibart and Mirikizumab in Adult Patients With Moderately to Severely Active Ulcerative Colitis

RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Sep 30, 2026 · NCT06598943

Study of XmAb942 in Healthy Participants and Participants With Ulcerative Colitis

RecruitingPhase 1/2Healthy volunteers welcome
Ages 18 to 75 · All sexes · Updated Sep 29, 2026 · NCT06619990

A Study of Long-acting Antibodies Alone and in Combinations for Moderate to Severe Ulcerative Colitis

RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Sep 29, 2026 · NCT07012395

A Trial to Investigate PALI-2108 Versus Placebo in Participants With Moderately to Severely Active Ulcerative Colitis

RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Sep 29, 2026 · NCT07845487

Immune Regulation in Ulcerative Colitis or Crohn s Disease

RecruitingObservational studyHealthy volunteers welcome
1 Day – 75 Years · All sexes · Updated Sep 28, 2026 · NCT00001184

A Protocol of Icotrokinra Therapy in Adult and Adolescent Participants With Moderately to Severely Active Ulcerative Colitis

RecruitingPhase 3
Ages 12 and older · All sexes · Updated Sep 25, 2026 · NCT07196748

A Long-term Extension (LTE) Study of Guselkumab in Pediatric Participants

RecruitingPhase 3
Ages 3 and older · All sexes · Updated Sep 25, 2026 · NCT06663332

A Study Investigating Oral Ozanimod (RPC1063) in Pediatric Participants With Moderate to Severe Active Ulcerative Colitis

RecruitingPhase 2/3
Ages 2 to 17 · All sexes · Updated Sep 24, 2026 · NCT05076175

Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT03816345

LY4268989 (MORF-057) Co-Administered With Mirikizumab in Adults With Moderately to Severely Active Ulcerative Colitis:

RecruitingPhase 2
Ages 18 to 80 · All sexes · Updated Sep 22, 2026 · NCT07186101

A Master Protocol (IIBD): A Study of Multiple Drugs in Adults With Ulcerative Colitis or Crohn's Disease

RecruitingPhase 2
Ages 18 to 80 · All sexes · Updated Sep 22, 2026 · NCT07483073

LY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis

RecruitingPhase 2
Ages 18 to 80 · All sexes · Updated Sep 22, 2026 · NCT07415044

A Study of Vedolizumab With Tofacitinib in Adults With Ulcerative Colitis (UC)

RecruitingPhase 4
Ages 18 to 65 · All sexes · Updated Sep 21, 2026 · NCT06095128

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.