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Ulcerative Colitis clinical trials recruiting in the U.S.
79 studies for Ulcerative Colitis are recruiting participants at sites across the United States.
Ulcerative Colitis (UC) can cause long-lasting swelling and ulcers in the large intestine. It is a type of inflammatory bowel disease. Find out more.
Cities with the most studies
- New York City, NY23 studies
- Orlando, FL22 studies
- Miami, FL21 studies
- Houston, TX17 studies
- San Antonio, TX16 studies
- Tacoma, WA15 studies
- Chicago, IL15 studies
- San Diego, CA15 studies
- Tyler, TX14 studies
- Colorado Springs, CO14 studies
- Los Angeles, CA13 studies
- St. Louis, MO13 studies
- Washington, DC12 studies
- Boston, MA11 studies
- Cincinnati, OH11 studies
- Providence, RI11 studies
- Louisville, KY10 studies
- Lewisville, TX10 studies
- Parma, OH10 studies
- Durham, NC10 studies
- Tampa, FL9 studies
- Lubbock, TX9 studies
- Evanston, IL9 studies
- Atlanta, GA9 studies
- Baltimore, MD8 studies
- Mountain View, CA8 studies
- Garland, TX8 studies
- Round Rock, TX8 studies
- Memphis, TN8 studies
- Scottsdale, AZ8 studies
- Dallas, TX8 studies
- Metairie, LA8 studies
- Cleveland, OH8 studies
- Seattle, WA8 studies
- Pittsburgh, PA7 studies
- Waukegan, IL7 studies
- Fort Worth, TX7 studies
- Charlotte, NC7 studies
- Anaheim, CA7 studies
- Wyoming, MI7 studies
By state
- Alabama7 studies
- Arizona19 studies
- Arkansas4 studies
- California39 studies
- Colorado17 studies
- Connecticut11 studies
- District of Columbia3 studies
- Florida31 studies
- Georgia14 studies
- Idaho4 studies
- Illinois24 studies
- Indiana10 studies
- Kansas10 studies
- Kentucky13 studies
- Louisiana15 studies
- Maryland13 studies
- Massachusetts16 studies
- Michigan17 studies
- Minnesota8 studies
- Mississippi6 studies
- Missouri16 studies
- Nevada6 studies
- New Hampshire5 studies
- New Jersey7 studies
- New York30 studies
- North Carolina23 studies
- Ohio26 studies
- Oklahoma4 studies
- Oregon5 studies
- Pennsylvania12 studies
- Rhode Island11 studies
- South Carolina12 studies
- South Dakota4 studies
- Tennessee12 studies
- Texas33 studies
- Utah7 studies
- Virginia14 studies
- Washington22 studies
- Wisconsin4 studies
Recently updated studies
Longitudinal Immunophenotyping of Patients With Inflammatory Bowel Disease
RecruitingObservational study
Ages 18 to 85 · All sexes · Updated Oct 2, 2026 · NCT07619547Aquamin® for Prevention of Ulcerative Colitis J-Pouch-associate Intestinal Inflammation
RecruitingPhase 2
Ages 18 to 80 · All sexes · Updated Oct 2, 2026 · NCT07501078Extension Study of Long-term Safety and Efficacy of Tulisokibart in Participants With Crohn's Disease or Ulcerative Colitis (MK-7240-011)
RecruitingPhase 3
All ages · All sexes · Updated Oct 2, 2026 · NCT06651281Study of Advanced Therapies for the Treatment of Adult Participants With Moderately to Severely Active Crohn's Disease or Ulcerative Colitis
RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Oct 2, 2026 · NCT07697456A Study of Vedolizumab in Adults With Ulcerative Colitis (UC) or Crohn's Disease (CD) in the Community Setting
RecruitingPhase 4
Ages 18 to 80 · All sexes · Updated Sep 30, 2026 · NCT06581328A Study to Learn More About How Risankizumab Works in Young Participants With Ulcerative Colitis
RecruitingPhase 3
Ages 2 to 17 · All sexes · Updated Sep 30, 2026 · NCT07071519Confirmatory Clinical Study in Active Ulcerative Colitis
RecruitingPhase 2
Ages 16 and older · All sexes · Updated Sep 30, 2026 · NCT07296315A Study of Eltrekibart and Mirikizumab in Adult Patients With Moderately to Severely Active Ulcerative Colitis
RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Sep 30, 2026 · NCT06598943Study of XmAb942 in Healthy Participants and Participants With Ulcerative Colitis
RecruitingPhase 1/2Healthy volunteers welcome
Ages 18 to 75 · All sexes · Updated Sep 29, 2026 · NCT06619990A Study of Long-acting Antibodies Alone and in Combinations for Moderate to Severe Ulcerative Colitis
RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Sep 29, 2026 · NCT07012395A Trial to Investigate PALI-2108 Versus Placebo in Participants With Moderately to Severely Active Ulcerative Colitis
RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Sep 29, 2026 · NCT07845487A Study to Evaluate Efficacy and Safety of MK-8690 in Participants With Moderately to Severely Active Ulcerative Colitis (MK-8690-002)
RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Sep 28, 2026 · NCT07463183A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics (PK) of RO7837195 in Participants With Moderately to Severely Active Ulcerative Colitis (UC)
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT06979336Immune Regulation in Ulcerative Colitis or Crohn s Disease
RecruitingObservational studyHealthy volunteers welcome
1 Day – 75 Years · All sexes · Updated Sep 28, 2026 · NCT00001184A Protocol of Icotrokinra Therapy in Adult and Adolescent Participants With Moderately to Severely Active Ulcerative Colitis
RecruitingPhase 3
Ages 12 and older · All sexes · Updated Sep 25, 2026 · NCT07196748A Long-term Extension (LTE) Study of Guselkumab in Pediatric Participants
RecruitingPhase 3
Ages 3 and older · All sexes · Updated Sep 25, 2026 · NCT06663332A Study Investigating Oral Ozanimod (RPC1063) in Pediatric Participants With Moderate to Severe Active Ulcerative Colitis
RecruitingPhase 2/3
Ages 2 to 17 · All sexes · Updated Sep 24, 2026 · NCT05076175Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study
RecruitingPhase 3
Ages 18 to 70 · All sexes · Updated Sep 24, 2026 · NCT06937086Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT03816345LY4268989 (MORF-057) Co-Administered With Mirikizumab in Adults With Moderately to Severely Active Ulcerative Colitis:
RecruitingPhase 2
Ages 18 to 80 · All sexes · Updated Sep 22, 2026 · NCT07186101A Master Protocol (IIBD): A Study of Multiple Drugs in Adults With Ulcerative Colitis or Crohn's Disease
RecruitingPhase 2
Ages 18 to 80 · All sexes · Updated Sep 22, 2026 · NCT07483073A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease (SHINE-ON)
RecruitingPhase 3
Ages 2 to 19 · All sexes · Updated Sep 22, 2026 · NCT04844606LY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis
RecruitingPhase 2
Ages 18 to 80 · All sexes · Updated Sep 22, 2026 · NCT07415044A Study of Vedolizumab With Tofacitinib in Adults With Ulcerative Colitis (UC)
RecruitingPhase 4
Ages 18 to 65 · All sexes · Updated Sep 21, 2026 · NCT06095128Proof of Concept Study Evaluating the Efficacy and Safety of ATH-063 Treatment in Patients With Relapsed/Refractory Moderately to Severely Active Ulcerative Colitis (UC)
RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Sep 21, 2026 · NCT07513181From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.