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Enhancing Rehabilitation for Veterans With Serious Mental Illness

Enhancing Rehabilitation for Veterans With Serious Mental Illness Via Biomarker-Informed Cognitive Training

Who can join

Ages 18 to 83 · All sexes

Inclusion Criteria:

* Veterans with SMI (e.g., schizophrenia, schizoaffective disorder, bipolar disorder, PTSD) being treated at PRRCs or co-located rehabilitative services.
* Age 18 and 83 years.
* Fluency in spoken and written English.
* Ability to detect 1000 Hz tones binaurally at a 40-dB sound pressure level.
* Ability to see with an acuity of 20/40 with both eyes tested together (corrected if applicable) by a standard printed Snellen eye chart reading card.

Exclusion Criteria:

* Estimated premorbid IQ below 70, as estimated via the WRAT-4 Reading subtest.
* Active substance use other than cannabis within the last 30 days as determined by CPRS review, self- report, or positive urine drug screen (obtained as part of the screening process).
* History of significant medical or neurological illness.
* Inability to comprehend or provide informed consent.

About the study

This study addresses the critical need for innovative therapeutic interventions in Veterans with serious mental illnesses (SMI) receiving care in VA Psychosocial Rehabilitation and Recovery Centers (PRRCs). The vast majority of individuals with SMI suffer from cognitive impairments, leading to chronic functional disability, and impaired outcomes, causing a significant strain on support networks and the VA healthcare system. This study aims to introduce an innovative mental health therapy, Targeted Cognitive Training (TCT), to Veterans struggling with serious mental illnesses (SMI). TCT works to improve basic sensory information processing and, ultimately, clinical, cognitive, and psychosocial functioning. By using EEG biomarkers to identify Veterans with SMI receiving care within VA Psychosocial Rehabilitation and Recovery Centers who are most likely to benefit from this treatment, and by understanding how best to implement this therapy, the investigators hope to enhance care and improve life quality for Veterans with SMI.

What is being tested

• Targeted Cognitive Training (behavioral)

Sponsor: VA Office of Research and Development · Participants: 80 · Started: Feb 25, 2025

Contact the study team

• Joyce Sprock, BS · Phone: (858) 552-8585
• Abigail A Mack · Phone: (858) 642-6492

Official record on ClinicalTrials.gov — NCT06586164

Locations in the U.S.

Conditions

• Schizophrenia
• Psychotic Disorders
• Post-Traumatic Stress Disorder
• Bipolar Disorder

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.