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Heart Diseases clinical trials recruiting in the U.S.
71 studies for Heart Diseases are recruiting participants at sites across the United States.
Heart disease is the leading cause of death in the U.S. Learn about the different types of heart diseases, and what you can do to try to prevent them.
Cities with the most studies
- New York City, NY18 studies
- Boston, MA14 studies
- Cleveland, OH13 studies
- Los Angeles, CA12 studies
- Portland, OR11 studies
- Philadelphia, PA11 studies
- Atlanta, GA10 studies
- Rochester, MN10 studies
- Dallas, TX10 studies
- Durham, NC10 studies
- Washington, DC9 studies
- Baltimore, MD9 studies
- Phoenix, AZ9 studies
- Chicago, IL9 studies
- St. Louis, MO9 studies
- Houston, TX9 studies
- Indianapolis, IN9 studies
- Pittsburgh, PA9 studies
- Columbus, OH8 studies
- Cincinnati, OH8 studies
- San Francisco, CA8 studies
- Nashville, TN7 studies
- San Diego, CA7 studies
- Austin, TX7 studies
- Minneapolis, MN6 studies
- Charleston, SC6 studies
- Newark, NJ6 studies
- Milwaukee, WI6 studies
- Kansas City, KS5 studies
- Norfolk, VA4 studies
- Tampa, FL4 studies
- Miami, FL4 studies
- Ann Arbor, MI4 studies
- Omaha, NE4 studies
- Hartford, CT4 studies
- Salt Lake City, UT4 studies
- Louisville, KY4 studies
- Arlington, VA4 studies
- Kansas City, MO4 studies
- Mountain View, CA4 studies
By state
- Arizona9 studies
- California21 studies
- Colorado7 studies
- Connecticut5 studies
- District of Columbia8 studies
- Florida13 studies
- Georgia11 studies
- Illinois12 studies
- Indiana10 studies
- Iowa3 studies
- Kansas5 studies
- Kentucky4 studies
- Louisiana3 studies
- Maryland12 studies
- Massachusetts17 studies
- Michigan9 studies
- Minnesota16 studies
- Missouri12 studies
- Nebraska4 studies
- New Jersey9 studies
- New York20 studies
- North Carolina12 studies
- Ohio19 studies
- Oklahoma4 studies
- Oregon11 studies
- Pennsylvania15 studies
- South Carolina6 studies
- Tennessee9 studies
- Texas16 studies
- Utah6 studies
- Vermont3 studies
- Virginia9 studies
- Washington5 studies
- West Virginia3 studies
- Wisconsin7 studies
Recently updated studies
Promoting Physical Activity and Fitness Among Underserved Latino Families Living in U.S.-Mexico Border Regions
RecruitingHealthy volunteers welcome
Ages 6 and older · All sexes · Updated Oct 2, 2026 · NCT06596902Gauging Outcomes of Total Milk Ingestion on Lipid and gControl
RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT07087184ELEVATE-HFpEF Clinical Study
Recruiting
Ages 40 and older · All sexes · Updated Oct 2, 2026 · NCT06678841Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System
RecruitingObservational studyHealthy volunteers welcome
Ages 1 to 100 · All sexes · Updated Oct 2, 2026 · NCT01143454New Heart Imaging Techniques to Evaluate Possible Heart Disease
RecruitingHealthy volunteers welcome
Ages 18 to 100 · All sexes · Updated Oct 2, 2026 · NCT01399385A Phase 1 AAV Gene Therapy Trial Evaluating Safety and Preliminary Efficacy of RP-A701 in Subjects With BAG3 Dilated Cardiomyopathy
RecruitingPhase 1
Ages 18 to 65 · All sexes · Updated Oct 1, 2026 · NCT07137338Transition to KPL-387 Monotherapy Dosing & Administration Study
RecruitingPhase 2
Ages 18 to 80 · All sexes · Updated Sep 30, 2026 · NCT07288216Safety and Effectiveness of the Sphere-9™ Catheter and Affera™ Ablation System for the Treatment of Ventricular Tachycardia (Sphere VT)
Recruiting
Ages 18 to 85 · All sexes · Updated Sep 29, 2026 · NCT07585968A Prospective, Multicenter, Randomized Controlled Trial to Investigate the Value of Coronary CT Angiography in the Understanding and Management of Coronary Calcium (The Optimal Trial)
Recruiting
Ages 18 to 85 · All sexes · Updated Sep 28, 2026 · NCT07286578Capitalizing on AI to CapTure Undiagnosed Structural Heart Disease
Recruiting
Ages 40 and older · All sexes · Updated Sep 25, 2026 · NCT07843004Personalized Environment and Genes Study
RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 120 · All sexes · Updated Sep 16, 2026 · NCT00341237Technical Development of Cardiovascular Magnetic Resonance Imaging
RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 100 · All sexes · Updated Sep 15, 2026 · NCT04927429Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.
Recruiting
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT03242642Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure
Recruiting
Ages 18 to 100 · All sexes · Updated Sep 9, 2026 · NCT06310031Safety and Performance Assessment of the Sphere-9™ Catheter and Affera™ Ablation System for the Treatment of Ventricular Tachycardia (Sphere-9 VT EFS)
Recruiting
Ages 18 to 85 · All sexes · Updated Sep 3, 2026 · NCT06703489Clinical Course Of Disease In Participants With FA-CM
RecruitingObservational study
Ages 6 and older · All sexes · Updated Sep 2, 2026 · NCT06865482Study of LX2006 Gene Therapy in Friedreich Ataxia Cardiomyopathy
RecruitingPhase 2
Ages 6 and older · All sexes · Updated Sep 2, 2026 · NCT07721025Abbott Structural Heart Device Registry
RecruitingObservational study
All ages · All sexes · Updated Sep 1, 2026 · NCT06590467Safety and Clinical Performance of the Freesolve Resorbable Magnesium Scaffold (RMS) System in Subjects With Coronary Artery Lesions
Recruiting
Ages 18 to 80 · All sexes · Updated Aug 31, 2026 · NCT07258290A Preliminary Study for INFORMED
RecruitingPhase 4
Ages 65 and older · All sexes · Updated Aug 21, 2026 · NCT05585125A Study Of Heart Disease Using AI-Enabled Electrocardiography And Focused Cardiac Ultrasound
Recruiting
Ages 18 and older · All sexes · Updated Aug 20, 2026 · NCT07351656Randomization of Single vs Multiple Arterial Grafts
Recruiting
Ages 18 to 70 · All sexes · Updated Aug 20, 2026 · NCT03217006Reduction or Elimination of Mitral Regurgitation With the SATURN TMVR System (CASSINI-US)
Recruiting
Ages 18 and older · All sexes · Updated Aug 10, 2026 · NCT07130994Ask Questions About Clinical Trials
Recruiting
Ages 18 and older · All sexes · Updated Aug 6, 2026 · NCT07343297Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant
RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Aug 4, 2026 · NCT06563895From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.