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Heart Diseases clinical trials recruiting in the U.S.

71 studies for Heart Diseases are recruiting participants at sites across the United States.

Heart disease is the leading cause of death in the U.S. Learn about the different types of heart diseases, and what you can do to try to prevent them.

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Recently updated studies

Promoting Physical Activity and Fitness Among Underserved Latino Families Living in U.S.-Mexico Border Regions

RecruitingHealthy volunteers welcome
Ages 6 and older · All sexes · Updated Oct 2, 2026 · NCT06596902

Gauging Outcomes of Total Milk Ingestion on Lipid and gControl

RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT07087184

ELEVATE-HFpEF Clinical Study

Recruiting
Ages 40 and older · All sexes · Updated Oct 2, 2026 · NCT06678841

Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System

RecruitingObservational studyHealthy volunteers welcome
Ages 1 to 100 · All sexes · Updated Oct 2, 2026 · NCT01143454

New Heart Imaging Techniques to Evaluate Possible Heart Disease

RecruitingHealthy volunteers welcome
Ages 18 to 100 · All sexes · Updated Oct 2, 2026 · NCT01399385

Transition to KPL-387 Monotherapy Dosing & Administration Study

RecruitingPhase 2
Ages 18 to 80 · All sexes · Updated Sep 30, 2026 · NCT07288216

Capitalizing on AI to CapTure Undiagnosed Structural Heart Disease

Recruiting
Ages 40 and older · All sexes · Updated Sep 25, 2026 · NCT07843004

Personalized Environment and Genes Study

RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 120 · All sexes · Updated Sep 16, 2026 · NCT00341237

Technical Development of Cardiovascular Magnetic Resonance Imaging

RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 100 · All sexes · Updated Sep 15, 2026 · NCT04927429

Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure

Recruiting
Ages 18 to 100 · All sexes · Updated Sep 9, 2026 · NCT06310031

Clinical Course Of Disease In Participants With FA-CM

RecruitingObservational study
Ages 6 and older · All sexes · Updated Sep 2, 2026 · NCT06865482

Study of LX2006 Gene Therapy in Friedreich Ataxia Cardiomyopathy

RecruitingPhase 2
Ages 6 and older · All sexes · Updated Sep 2, 2026 · NCT07721025

Abbott Structural Heart Device Registry

RecruitingObservational study
All ages · All sexes · Updated Sep 1, 2026 · NCT06590467

A Preliminary Study for INFORMED

RecruitingPhase 4
Ages 65 and older · All sexes · Updated Aug 21, 2026 · NCT05585125

A Study Of Heart Disease Using AI-Enabled Electrocardiography And Focused Cardiac Ultrasound

Recruiting
Ages 18 and older · All sexes · Updated Aug 20, 2026 · NCT07351656

Randomization of Single vs Multiple Arterial Grafts

Recruiting
Ages 18 to 70 · All sexes · Updated Aug 20, 2026 · NCT03217006

Reduction or Elimination of Mitral Regurgitation With the SATURN TMVR System (CASSINI-US)

Recruiting
Ages 18 and older · All sexes · Updated Aug 10, 2026 · NCT07130994

Ask Questions About Clinical Trials

Recruiting
Ages 18 and older · All sexes · Updated Aug 6, 2026 · NCT07343297

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.