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Metastatic Cancer clinical trials in San Diego, CA

30 studies for Metastatic Cancer are looking for participants at sites in and around San Diego (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Atebimetinib + GnP as a First Line Treatment in Patients With Metastatic Pancreatic Adenocarcinoma

RecruitingPhase 3
  • University of California San Diego, San Diego
Ages 18 and older · All sexes · Updated Oct 5, 2026 · NCT07562152

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

RecruitingPhase 2
  • UC San Diego Medical Center - Hillcrest, San Diego
  • Sharp Memorial Hospital, San Diego
  • UC San Diego Moores Cancer Center, La Jolla · 11 mi away
All ages · All sexes · Updated Oct 5, 2026 · NCT05564377

A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors

RecruitingPhase 1
  • University of California, San Diego (UCSD) - Moores Cancer Center, La Jolla · 11 mi away
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06465069

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

RecruitingPhase 1/2
  • University of San Diego Moores Cancer Center, La Jolla · 11 mi away
Ages 12 and older · All sexes · Updated Oct 2, 2026 · NCT04585750

A Study of HC-7366 in Combination With Belzutifan (WELIREG™) in Patients With Renal Cell Carcinoma

RecruitingPhase 1
  • University of California San Diego Moores Cancer Center, La Jolla · 11 mi away
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06234605

Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors

RecruitingPhase 1
  • University of California San Diego Moores Cancer Center, San Diego
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06625775

A First in Human Study of ALX2004 With Advanced or Metastatic Selected Solid Tumors

RecruitingPhase 1
  • ALX Center 9, La Jolla · 11 mi away
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT07085091

Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer

RecruitingPhase 3
  • UC San Diego McGrath Outpatient Pavilion - Hillcrest, San Diego
  • UC San Diego Medical Center - Hillcrest, San Diego
  • UC San Diego Medical Center - Rancho Bernardo, San Diego
  • and 3 more
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07222800

ASPEN-09-03: A Study of Evorpacept in Combination With Trastuzumab and Chemotherapy in Metastatic HER2-Positive Breast Cancer

RecruitingPhase 2
  • UC San Diego Moores Cancer Center, La Jolla · 11 mi away
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07007559

A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue

RecruitingPhase 2/3
  • UC San Diego Medical Center - Bankers Hill, San Diego
  • UC San Diego McGrath Outpatient Pavilion - Hillcrest, San Diego
  • UC San Diego Medical Center - Hillcrest, San Diego
  • and 5 more
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06989437

Intratumoral N17350 in Advanced Solid Tumors

RecruitingPhase 1/2
  • Scripps Clinic Torrey Pines - La Jolla, San Diego
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07339176

A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer

RecruitingPhase 3
  • Moores Cancer Center, La Jolla · 11 mi away
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07213804

A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

RecruitingPhase 3
  • Moores Cancer Center, La Jolla · 11 mi away
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07174336

Symbiotic-GU-08: A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Anticancer Therapies in Adults With Locally Advanced or Metastatic Renal Cell Cancer

RecruitingPhase 1/2
  • UC San Diego Medical Center - Bankers Hill, San Diego
  • UC San Diego McGrath Outpatient Pavilion - Hillcrest, San Diego
  • UC San Diego Medical Center - Hillcrest, San Diego
  • and 5 more
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07227415

NPX372, a B7-H7:CD3 Bispecific Antibody, in Selected Solid Tumor Malignancies

RecruitingPhase 1
  • University of California - San Diego, La Jolla · 11 mi away
Ages 19 and older · All sexes · Updated Sep 8, 2026 · NCT07563829

Personalized Antibody-Drug Conjugate Therapy Based on RNA and Protein Testing for the Treatment of Advanced or Metastatic Solid Tumors (The ADC MATCH Screening and Treatment Trial)

RecruitingPhase 2
  • UC San Diego Medical Center - Hillcrest, San Diego
  • UC San Diego Moores Cancer Center, La Jolla · 11 mi away
Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT06311214

Study of the Bria-IMT Regimen and CPI vs Physicians' Choice in Advanced Metastatic Breast Cancer.

RecruitingPhase 3
  • UC San Diego, San Diego
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT06072612

A Study to Evaluate KIN-2787 in Participants With BRAF and/or NRAS Mutation Positive Solid Tumors

RecruitingPhase 1
  • University of California San Diego, Moores Cancer Center, San Diego
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT04913285

A Study With NKT5097 for Adults With Advanced/Metastatic Solid Tumors

RecruitingPhase 1
  • UC San Diego Moores Cancer Center, La Jolla · 11 mi away
Ages 18 and older · All sexes · Updated Aug 28, 2026 · NCT07029399

Studying the Safety and Determining the Optimal Dose of Novobiocin in Patients With Tumors That Have Alterations in DNA Repair Genes

RecruitingPhase 1
  • UC San Diego Medical Center - Hillcrest, San Diego
  • UC San Diego Moores Cancer Center, La Jolla · 11 mi away
Ages 18 and older · All sexes · Updated Aug 3, 2026 · NCT05687110

Puxitatug Samrotecan (AZD8205) Monotherapy vs Chemotherapy in B7-H4-selected Endometrial Cancer (Bluestar-Endometrial01)

RecruitingPhase 3
  • Research Site, La Jolla · 11 mi away
Ages 18 and older · Women · Updated Jul 29, 2026 · NCT07044336

Study of Orally Administered MOMA-313 in Participants With Advanced or Metastatic Solid Tumors

RecruitingPhase 1
  • Investigative Site #101, La Jolla · 11 mi away
Ages 18 and older · All sexes · Updated Jul 23, 2026 · NCT06545942

Study of Orally Administered MOMA-341 in Participants With Advanced or Metastatic Solid Tumors

RecruitingPhase 1
  • Investigative Site #101, San Diego
Ages 18 and older · All sexes · Updated Jul 23, 2026 · NCT06974110

Cemiplimab Plus Gemcitabine in Patients With Metastatic Pancreatic Adenocarcinoma

RecruitingPhase 2
  • University of California, San Diego, La Jolla · 11 mi away
Ages 18 and older · All sexes · Updated Jun 8, 2026 · NCT06790602

BBO-11818 in Adult Subjects With KRAS Mutant Cancer

RecruitingPhase 1
  • University of California San Diego Moores Cancer Center, San Diego
Ages 18 and older · All sexes · Updated Jun 2, 2026 · NCT06917079

A Randomized, Phase 2/3 Study to Investigate the Efficacy and Safety of RP2 in Combination With Nivolumab in Immune Checkpoint Inhibitor-Naïve Adult Patients With Metastatic Uveal Melanoma

RecruitingPhase 2/3
  • UC San Diego Moores Cancer Center, La Jolla · 11 mi away
All ages · All sexes · Updated Apr 2, 2026 · NCT06581406

A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors

RecruitingPhase 1/2
  • University of California San Diego (UC San Diego) Health - Jacobs Medical Center - Moores Cancer Center, La Jolla · 11 mi away
Ages 18 and older · All sexes · Updated Mar 18, 2026 · NCT06244771

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, La Jolla · 11 mi away
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

A Beta-only IL-2 ImmunoTherapY Study

RecruitingPhase 1/2
  • Sharp Memorial Hospital, San Diego
Ages 18 and older · All sexes · Updated Jul 9, 2025 · NCT05086692

ACE2016 in Adult Subjects With Locally Advanced or Metastatic Solid Tumors Expressing Epidermal Growth Factor Receptor (EGFR)

RecruitingPhase 1
  • University of California San Diego, San Diego
Ages 18 and older · All sexes · Updated Jul 1, 2025 · NCT06415487

Metastatic Cancer trials in other cities

Other studies in San Diego

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.