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Heart Failure clinical trials in San Diego, CA

23 studies for Heart Failure are looking for participants at sites in and around San Diego (within about 30 miles). Open a study to see who can join and how to contact the study team.

A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF

RecruitingPhase 3
  • Research Site, San Diego
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07761117

Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction

RecruitingPhase 3
  • San Diego Cardiac Center, San Diego
  • UC San Diego Health - Sulpizio Cardiovascular Center, La Jolla · 11 mi away
Ages 18 to 85 · All sexes · Updated Sep 24, 2026 · NCT06736574

A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart

RecruitingPhase 3
  • University of California San Diego, San Diego
  • Paradigm Clinical Research - San Diego, San Diego
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06935370

Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

RecruitingPhase 3
  • San Diego Cardiac Center, San Diego
Ages 18 to 99 · All sexes · Updated Sep 16, 2026 · NCT07037459

Alleviant ALLAY-HFrEF Study

Recruiting
  • Scripps Clinical Research Services, San Diego
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT06812533

Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin

RecruitingPhase 3
  • Research Site, San Diego
  • Research Site, La Jolla · 11 mi away
Ages 40 and older · All sexes · Updated Sep 15, 2026 · NCT06677060

Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function

RecruitingPhase 3
  • Research Site, San Diego
Ages 18 to 130 · All sexes · Updated Sep 11, 2026 · NCT06307652

Safety and Effectiveness of Left Bundle Branch Area Pacing Versus Conventional Cardiac Resynchronization Therapy in Heart Failure

Recruiting
  • Scripps Memorial Hospital, La Jolla · 11 mi away
Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT07069738

A Study of EDG-15400 in Adults With Heart Failure With Preserved Ejection Fraction (EQUINOX-HFpEF)

RecruitingPhase 2
  • Local Institution - 120, San Diego
Ages 30 to 84 · All sexes · Updated Aug 31, 2026 · NCT07795814

Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products

RecruitingObservational study
  • La Jolla, La Jolla · 11 mi away
All ages · All sexes · Updated Aug 20, 2026 · NCT00271180

A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity

RecruitingPhase 3
  • G&J Research, San Diego
  • San Diego Veterans Affairs, San Diego
  • Scripps Memorial Hospital La Jolla, La Jolla · 11 mi away
  • and 1 more
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT07567001

Alleviant ALLAY-HF Study

Recruiting
  • Scripps Clinical Research Services, San Diego
Ages 40 and older · All sexes · Updated Aug 14, 2026 · NCT05685303

Assessment of CCM in HF With Higher Ejection Fraction

Recruiting
  • University of California San Diego, La Jolla · 11 mi away
Ages 18 and older · All sexes · Updated Aug 6, 2026 · NCT05064709

A Study to Evaluate Finerenone on Clinical Efficacy and Safety in Patients With Heart Failure Who Are Intolerant or Not Eligible for Treatment With Steroidal Mineralocorticoid Receptor Antagonists

RecruitingPhase 3
  • FIN-10406, San Diego, CA, San Diego
  • San Diego, CA Investigative Site FIN-10420, San Diego
  • FIN-10075 San Diego, CA Investigational Site, San Diego
Ages 18 and older · All sexes · Updated Jul 10, 2026 · NCT06033950

A Phase 1 AAV Gene Therapy Trial Evaluating Safety and Preliminary Efficacy of RP-A701 in Subjects With BAG3 Dilated Cardiomyopathy

RecruitingPhase 1
  • University of California, San Diego, San Diego
Ages 18 to 65 · All sexes · Updated Jun 30, 2026 · NCT07137338

The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR

Recruiting
  • Scripps Health, San Diego
Ages 18 and older · All sexes · Updated Apr 13, 2026 · NCT03142152

XVIVO Heart Box (XHB) With Supplemented XVIVO Heart Solution (SXHS) Continued Access Protocol (CAP)

Recruiting
  • UC San Diego Health, La Jolla · 11 mi away
Ages 18 and older · All sexes · Updated Mar 18, 2026 · NCT06895070

Left vs Left Randomized Clinical Trial

Recruiting
  • University of California San Diego, La Jolla · 11 mi away
Ages 18 and older · All sexes · Updated Oct 2, 2025 · NCT05650658

AN INTERNATIONAL, OBSERVATIONAL, BLINDED STUDY TO ASSESS THE PERFORMANCE OF THE CORDIO HEARO SYSTEM

RecruitingObservational study
  • VA San Diego, San Diego
  • UC San Diego Health, La Jolla · 11 mi away
Ages 22 and older · All sexes · Updated Mar 26, 2025 · NCT06378632

Cardiotoxicity Assessment Through Comprehensive Heart Imaging to Predict Heart Failure

RecruitingObservational study
  • Rady Children's Hospital, San Diego
Ages 13 to 39 · All sexes · Updated Jan 28, 2025 · NCT04262830

HF2 Registry - Hemodynamic Frontiers in Heart Failure Registry

RecruitingObservational study
  • Scripps Health, La Jolla · 11 mi away
Ages 18 to 100 · All sexes · Updated May 22, 2024 · NCT06425848

Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Reduced Ejection Fraction

RecruitingPhase 1/2
  • San Diego Cardiac Center, San Diego
Ages 18 to 80 · All sexes · Updated Mar 26, 2024 · NCT04703842

About Heart Failure

Heart failure, or congestive heart failure (CHF), means the heart can't pump enough blood. Learn about the signs, symptoms, and causes.

More about Heart Failure on MedlinePlus

Heart Failure trials in other cities

Other studies in San Diego

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.