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Depression clinical trials in San Diego, CA

21 studies for Depression are looking for participants at sites in and around San Diego (within about 30 miles). Open a study to see who can join and how to contact the study team.

A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 2
  • Artemis Institute For Clinical Research - San Diego, San Diego
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07621237

RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses

RecruitingPhase 2
  • Kadima Neuropsychiatry Institute, San Diego
Ages 18 to 80 · All sexes · Updated Sep 15, 2026 · NCT07002034

Meditative Neurofeedback for Depression

Recruiting
  • University of California San Diego, La Jolla · 11 mi away
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT06675240

A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder (X-NOVA3)

RecruitingPhase 3
  • Artemis Institute for Clinical Research, San Diego
  • Center for Neurohealth, La Jolla · 11 mi away
Ages 18 to 74 · All sexes · Updated Sep 8, 2026 · NCT07076407

A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression

RecruitingPhase 2
  • Draig Clinical Site, San Diego
Ages 18 to 75 · All sexes · Updated Aug 26, 2026 · NCT07300969

Type I Hybrid Effectiveness-Implementation Trial of Primary Care Brief Mindfulness Training for Veterans

Recruiting
  • VA San Diego Healthcare System, San Diego, CA, San Diego
Ages 18 and older · All sexes · Updated Aug 19, 2026 · NCT06162741

Postpartum Education Via Artificial Intelligence for Recovery and Loneliness: A Randomized Controlled Trial

Recruiting
  • University of California San Diego, La Jolla · 11 mi away
Ages 18 and older · Women · Updated Aug 5, 2026 · NCT07223736

Sleep and Light Intervention (SALI) for Menopausal Mood Dysfunction

Recruiting
  • University of California San Diego Hillcrest Medical Center, San Diego
Ages 45 to 75 · Women · Updated Aug 5, 2026 · NCT06678880

E-Mindfulness Approaches for Living After Breast Cancer

RecruitingPhase 3
  • Kaiser Permanente-San Diego Zion, San Diego
Ages 18 to 50 · All sexes · Updated Aug 4, 2026 · NCT06748222

Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 3
  • Neurocrine Clinical Site, San Diego
Ages 18 and older · All sexes · Updated Jul 24, 2026 · NCT06966401

Be Well at Work-Plus: A Depression and Physical Activity Intervention for Hospital Service Workers (Aim 2)

Recruiting
  • San Diego State University, San Diego
Ages 18 and older · All sexes · Updated Jun 1, 2026 · NCT06753123

A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)

RecruitingPhase 2
  • Kadima Neuropsychiatry Institute, La Jolla · 11 mi away
Ages 18 to 65 · All sexes · Updated May 11, 2026 · NCT06524830

Mindfulness Engaged Neurostimulation for Depression (MEND II)

RecruitingPhase 2
  • UC San Diego Health Psychiatry, San Diego
Ages 18 to 65 · All sexes · Updated May 6, 2026 · NCT07512284

Combined Neuromodulation and Cognitive Training for Post-mTBI Depression

Recruiting
  • UCSD, La Jolla · 11 mi away
Ages 18 to 65 · All sexes · Updated May 1, 2026 · NCT05682677

Sleep Health in U.S. Marines

RecruitingPhase 2Healthy volunteers welcome
  • San Diego State University, San Diego
Ages 18 and older · All sexes · Updated Apr 16, 2026 · NCT07420205

ATLAS-1: Advanced Trial for Longitudinal Assessment in Salma 1

RecruitingObservational study
  • Salma Health, La Jolla · 11 mi away
Ages 18 and older · All sexes · Updated Apr 14, 2026 · NCT07528014

Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 3
  • Neurocrine Clinical Site, San Diego
Ages 18 and older · All sexes · Updated Oct 29, 2025 · NCT06786624

Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol (R33)

RecruitingPhase 2/3
  • UC San Diego, San Diego
Ages 21 to 55 · All sexes · Updated Oct 24, 2025 · NCT06273527

A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms

RecruitingPhase 4
  • Clinical Research Site, San Diego
Ages 18 to 65 · All sexes · Updated Jan 23, 2025 · NCT06223880

Combined Transcranial Magnetic Stimulation and Therapy for MTBI Related Headaches

Recruiting
  • VA San Diego Healthcare System, San Diego
Ages 18 to 65 · All sexes · Updated Nov 21, 2024 · NCT05176392

About Depression

Depression is a serious medical illness. It affects almost 7 percent of U.S. adults. It causes feelings of sadness, hopelessness, and frustration that do not go away. Learn about treatments.

More about Depression on MedlinePlus

Depression trials in other cities

Other studies in San Diego

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.