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Smoking and Youth clinical trials recruiting in the U.S.
75 studies for Smoking and Youth are recruiting participants at sites across the United States.
The younger you are when you start smoking, the more health problems it can cause. Know the risks of smoking cigarettes for people under age 21.
Cities with the most studies
- Atlanta, GA6 studies
- Houston, TX6 studies
- Charleston, SC5 studies
- New York City, NY5 studies
- St. Louis, MO4 studies
- Boston, MA4 studies
- New Haven, CT3 studies
- Chicago, IL3 studies
- Orlando, FL3 studies
- Los Angeles, CA3 studies
- Philadelphia, PA3 studies
- Minneapolis, MN3 studies
By state
- California8 studies
- Connecticut3 studies
- Florida5 studies
- Georgia7 studies
- Illinois5 studies
- Maryland3 studies
- Massachusetts4 studies
- Minnesota4 studies
- Missouri6 studies
- New Jersey3 studies
- New York11 studies
- North Carolina5 studies
- Pennsylvania5 studies
- South Carolina6 studies
- Texas7 studies
- Virginia3 studies
Recently updated studies
Pain and Smoking Study 2.0: A Randomized Clinical Trial of Smoking Cessation Among Veterans With Chronic Pain
Recruiting
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT06442514A Study Of Vagal Nerve Stimulation In Conjunction With NRT For Smoking Cessation
RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07487818DoubleTake: Effect of Message Exposure Via a Discrete Choice Experiment With Eye-Tracking on Quit Attempts Among Adults Who Smoke Menthol Cigarettes
RecruitingHealthy volunteers welcome
Ages 21 and older · All sexes · Updated Sep 25, 2026 · NCT07782879Nicotinic Receptor Genetic Variation and Alcohol Reward
RecruitingPhase 1Healthy volunteers welcome
Ages 21 to 60 · All sexes · Updated Sep 25, 2026 · NCT03294460A Study of Brenipatide in Adults Who Quit Smoking Cigarettes and Want to Avoid Relapse
RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Sep 22, 2026 · NCT07223840Empowering Patients' Lung Cancer Screening Uptake (Empower LCS/Call+)
Recruiting
Ages 50 to 80 · All sexes · Updated Sep 21, 2026 · NCT07711691Semaglutide for Post-Smoking Cessation Weight Management
RecruitingPhase 2Healthy volunteers welcome
Ages 18 to 75 · All sexes · Updated Sep 21, 2026 · NCT06173778Actívatexto: Advancing Smoking Cessation and Physical Activity Among Latinos
Recruiting
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT06926608Circuitry-Guided Smoking Cessation in Schizophrenia (UH3)
Recruiting
Ages 22 to 65 · All sexes · Updated Sep 16, 2026 · NCT05276050Varenicline and Accelerated Transcranial Magnetic Stimulation (TMS) for Quitting Nicotine Use (Pilot Study)
RecruitingPhase 4
Ages 18 to 65 · All sexes · Updated Sep 15, 2026 · NCT07145866Overcoming Nicotine Dependence to Enable Quitting
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT05513872Studying NMDA and Sigma-1 in Smoking Cessation Treatment (SUMMIT)
RecruitingPhase 3
Ages 18 to 65 · All sexes · Updated Sep 8, 2026 · NCT07766655Vaped Phenanthrene
RecruitingHealthy volunteers welcome
Ages 21 and older · All sexes · Updated Sep 3, 2026 · NCT07134426A Study Evaluating the Use of an Indoor Air Quality Monitor to Promote a Smoke-free Home
RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Aug 27, 2026 · NCT06693700Screening, Evaluation and Assessment (SEA) Protocol at the NIDA IRP
RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 99 · All sexes · Updated Aug 24, 2026 · NCT06552741Evaluation of Low and High Nicotine Tobacco Free Nicotine Pouches
RecruitingHealthy volunteers welcome
Ages 21 and older · All sexes · Updated Aug 20, 2026 · NCT06678789A Clinical Trial of Adaptive Treatment for Early Smoking Cessation Relapse
RecruitingHealthy volunteers welcome
Ages 21 and older · All sexes · Updated Aug 12, 2026 · NCT06118502Refer2Quit: Evaluating a Proactive, Tailored, Population Health Approach for Tobacco Treatment for Household Smokers Through a Pediatric Care Network
Recruiting
Ages 18 and older · All sexes · Updated Aug 6, 2026 · NCT06582693Personalized Tobacco Treatment in Primary Care (MOTIVATE)
Recruiting
Ages 18 and older · All sexes · Updated Aug 3, 2026 · NCT05846841Precision Treatment to Promote Smoking Cessation and Survival in Oncology Patients
Recruiting
Ages 18 to 89 · All sexes · Updated Jul 24, 2026 · NCT07166120Project DEDUCE: Digital Envirotyping to Develop Understanding of Cigarette Smoking and the Environment
RecruitingPhase 4
Ages 21 and older · All sexes · Updated Jul 23, 2026 · NCT07089901Impact of Cigarette and E-cigarette Menthol Regulation on Current Smokers of Menthol Cigarettes
RecruitingHealthy volunteers welcome
Ages 21 and older · All sexes · Updated Jul 21, 2026 · NCT05896033Bayesian Neurobehavioral Phenotyping: From Mechanism Identification to Personalized Neuromodulation Treatments. R61 PHASE
Recruiting
Ages 21 to 60 · All sexes · Updated Jul 21, 2026 · NCT06991062A Multi-Site Study to Assess the Effect of Availability of a Heated Tobacco Product on Smoking Abstinence Among Current Primary Cigarette Smokers
RecruitingHealthy volunteers welcome
Ages 21 to 65 · All sexes · Updated Jul 17, 2026 · NCT07710820Multi-Site Trial of Tirzepatide for Smoking Cessation
RecruitingPhase 2
Ages 21 to 65 · All sexes · Updated Jul 17, 2026 · NCT07602699From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.