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Breast Cancer clinical trials in Santa Monica, CA

28 studies for Breast Cancer are looking for participants at sites in and around Santa Monica (within about 30 miles). Open a study to see who can join and how to contact the study team.

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Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer

RecruitingPhase 3
  • Beverly Hills Cancer Center, Beverly Hills · 6 mi away
Ages 18 and older · All sexes · Updated Oct 5, 2026 · NCT06982521

A Study of PHST001 in Advanced Solid Tumors

RecruitingPhase 1
  • Precision NextGen Oncology & Research Center, Beverly Hills · 6 mi away
Ages 18 and older · All sexes · Updated Oct 5, 2026 · NCT06840886

A Study of Alisertib in Combination With Endocrine Therapy in Patients With HR-positive, HER2-negative Recurrent or Metastatic Breast Cancer

RecruitingPhase 2
  • Beverly Hills Cancer Center, Beverly Hills · 6 mi away
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06369285

A Study of NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation

RecruitingPhase 1
  • Research Site, Santa Monica
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT05877599

A Study of KIVU-107 in Participants With Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 1
  • Kivu Trial Site, Santa Monica
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT07229313

Signatera-Guided CDK4/6 Inhibitor Therapy in Breast Cancer

Recruiting
  • UCLA David Geffen School of Medicine, Santa Monica
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07214532

A Study to Compare the Steady-State Bioavailability of Injectable Letrozole SIE and Oral Letrozole in Post-Menopausal Women With Hormone Receptor Positive Early Breast Cancer

RecruitingPhase 1
  • Precision NextGen Oncology and Research Center (Investigational Site number USA-001), Beverly Hills · 6 mi away
Ages 18 to 80 · Women · Updated Sep 23, 2026 · NCT07401381

Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast Cancer

RecruitingPhase 3
  • Clinical Trial Site, Beverly Hills · 6 mi away
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07085767

A Study of LY4257496 in Participants With Cancer (OMNIRAY)

RecruitingPhase 1
  • University of California, Los Angeles (UCLA), Santa Monica
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07114601

A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

RecruitingPhase 3
  • UCLA Hematology/Oncology - Parkside, Santa Monica
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07174336

A Study of Imlunestrant (LY3484356) in Premenopausal Women With Estrogen Receptor-Positive (ER+) Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Early Breast Cancer

RecruitingPhase 2
  • UCLA Hematology/Oncology - Parkside, Santa Monica
Ages 18 and older · Women · Updated Sep 22, 2026 · NCT07287098

ROSETTA Breast-01: The Effects and Safety of Pumitamig in Patients With Triple-Negative Breast Cancer

RecruitingPhase 3
  • Saint John's Health Center - John Wayne Cancer Institute (JWCI), Santa Monica
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07173751

A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence

RecruitingPhase 3
  • Cedars-Sinai Cancer Beverly Hills, Beverly Hills · 6 mi away
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT06492616

A Phase I/IIa Study of AZD8205 Given Alone or Combined, in Participants With Advanced/Metastatic Solid Malignancies

RecruitingPhase 1/2
  • Research Site, Santa Monica
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT05123482

Study of the Bria-IMT Regimen and CPI vs Physicians' Choice in Advanced Metastatic Breast Cancer.

RecruitingPhase 3
  • St. John's Cancer Center, Santa Monica
  • UCLA-Department of Medicine Hematology/Oncology-Parkside, Santa Monica
  • UCLA-Hetamtology/Oncology_S Monica, Santa Monica
  • and 1 more
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT06072612

Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

RecruitingPhase 3
  • Tower Cancer Research Foundation, Beverly Hills · 6 mi away
  • Cedars-Sinai Cancer - Tarzana, Tarzana · 11 mi away
  • Kaiser Permanente-Woodland Hills, Woodland Hills · 12 mi away
Ages 18 to 60 · Women · Updated Sep 2, 2026 · NCT05879926

A Study of Oral MBQ-167 in Participants With Advanced Breast Cancer

RecruitingPhase 1
  • Precision Next Gen Oncology & Research Center, Beverly Hills · 6 mi away
Ages 21 and older · All sexes · Updated Aug 31, 2026 · NCT06075810

IIT2023-09-Chung-UpfrontTAD: Upfront TAD/SNB in Patients With Breast Cancer With Nodal Metastases

RecruitingPhase 2
  • CS Cancer at Valley Oncology Medical Group, Tarzana · 11 mi away
Ages 45 and older · Women · Updated Aug 10, 2026 · NCT06092892

Phase 3 Study to Evaluate the Efficacy and Safety of HER2/Neu Peptide GLSI-100 (GP2 + GM-CSF) in HER2/Neu Positive Subjects

RecruitingPhase 3
  • University of California Los Angeles - Hematology / Oncology Parkside, Santa Monica
Ages 18 to 100 · All sexes · Updated Aug 6, 2026 · NCT05232916

E-Mindfulness Approaches for Living After Breast Cancer

RecruitingPhase 3
  • Kaiser Permanente-Woodland Hills, Woodland Hills · 12 mi away
Ages 18 to 50 · All sexes · Updated Aug 4, 2026 · NCT06748222

A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations

RecruitingPhase 2
  • University of California Los Angeles Rheumatology, Westwood, Los Angeles · 4 mi away
  • Precision NextGen Oncology & Research Center, Beverly Hills · 6 mi away
Ages 8 and older · All sexes · Updated Jul 27, 2026 · NCT05503797

A Study of Emiltatug Ledadotin (Emi-Le) in Participants With Solid Tumors

RecruitingPhase 1/2
  • UCLA David Geffen School of Medicine, Division of Hematology/Oncology, Santa Monica
Ages 18 and older · All sexes · Updated Jun 29, 2026 · NCT05377996

Study of CX-5461 in Patients With Solid Tumours and BRCA1/2, PALB2 or Homologous Recombination Deficiency (HRD) Mutation

RecruitingPhase 1
  • University of California, Los Angeles, Santa Monica
Ages 18 and older · All sexes · Updated Jun 8, 2026 · NCT04890613

De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

RecruitingPhase 3
  • Cedars-Sinai Cancer - Tarzana, Tarzana · 11 mi away
Ages 50 to 70 · All sexes · Updated Apr 23, 2026 · NCT04852887

A Study of DB-1310 in Advanced/Metastatic Solid Tumors

RecruitingPhase 1/2
  • UCLA Hematology/Oncology - Santa Monica, Santa Monica
Ages 18 and older · All sexes · Updated Apr 6, 2026 · NCT05785741

Registry for Intra-Operative Radiotherapy During Breast Conserving Surgery in Patients With Early Stage Breast Cancer

RecruitingObservational study
  • John Wayne Cancer Institute, Providence Saint John's Health Center, Santa Monica
Ages 18 and older · All sexes · Updated Apr 16, 2024 · NCT04603209

About Breast Cancer

Breast cancer is a cancer that starts in the breast tissue, when cells change and grow out of control. These extra cells can form a mass called a tumor.

More about Breast Cancer on MedlinePlus

Breast Cancer trials in other cities

Other studies in Santa Monica

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.