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Triple-Negative Breast Cancer clinical trials in Philadelphia, PA

13 studies for Triple-Negative Breast Cancer are looking for participants at sites in and around Philadelphia (within about 30 miles). Open a study to see who can join and how to contact the study team.

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The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

RecruitingPhase 1/2
  • Abramson Cancer Center of the University of Pennsylvania, Philadelphia
Ages 12 and older · All sexes · Updated Oct 2, 2026 · NCT04585750

A Study With NKT3964 for Adults With Advanced/Metastatic Solid Tumors

RecruitingPhase 1
  • Sidney Kimmell Cancer Center - Jefferson Health, Philadelphia
Ages 19 and older · All sexes · Updated Oct 1, 2026 · NCT06586957

Study of AVZO-021 in Patients With Advanced Solid Tumors

RecruitingPhase 1/2
  • Avenzo Therapeutics Recruiting Site, Philadelphia
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT05867251

Sacituzumab Tirumotecan (MK-2870) Plus Pembrolizumab Versus TPC in TNBC Who Did Not Achieve pCR (MK-2870-012)

RecruitingPhase 3
  • Sidney Kimmel Cancer Center at Jefferson ( Site 0049), Philadelphia
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06393374

Evolutionary Clinical Trial for Novel Biomarker-Driven Therapies

RecruitingPhase 2
  • University of Pennsylvania/Abramson Cancer Center, Philadelphia
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT07340541

Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)

RecruitingPhase 3
  • University of Pennsylvania Abramson Cancer Center, Philadelphia
  • Lankenau Medical Center, Wynnewood · 7 mi away
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT05633654

A Phase 1 Study of NRM-823 in Participants With Locally Advanced or Metastatic Refractory Solid Tumors

RecruitingPhase 1
  • Normunity Investigational Site, Philadelphia
  • Normunity Investigational Site, Philadelphia
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT07182149

A Study of Izalontamab Brengitecan Versus Chemotherapy in Participants With Previously Untreated, Locally Advanced, Recurrent Inoperable, or Metastatic Triple-negative Breast Cancer Ineligible for Anti-PD(L)1 Drugs (IZABRIGHT-Breast01)

RecruitingPhase 2/3
  • Abramson Cancer Center of The University of Pennsylvania, Philadelphia
Ages 18 and older · All sexes · Updated Aug 10, 2026 · NCT06926868

I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer

RecruitingPhase 2
  • University of Pennsylvania (U Penn), Philadelphia
Ages 18 and older · All sexes · Updated May 6, 2026 · NCT01042379

Atezolizumab + Sacituzumab Govitecan to Prevent Recurrence in TNBC (ASPRIA)

RecruitingPhase 2
  • University of Pennsylvania-Abramson Cancer Center, Philadelphia
Ages 18 and older · All sexes · Updated May 4, 2026 · NCT04434040

Sacituzumab Govitecan +/- Pembrolizumab in Metastatic TNBC

RecruitingPhase 2
  • University of Pennsylvania-Abramson Cancer Center, Philadelphia
Ages 18 and older · All sexes · Updated Apr 29, 2026 · NCT04468061

Pre-operative SABR With and Without Caloric Restriction for Early Stage Breast Cancer

Recruiting
  • Thomas Jefferson University Hospital, Philadelphia
Ages 40 and older · All sexes · Updated Jan 23, 2026 · NCT04959474

Role of the Immune Environment in Response to Therapy in Breast Cancer

RecruitingObservational study
  • Abramson Cancer Center, Philadelphia
Ages 18 and older · Women · Updated Jul 8, 2025 · NCT05396612

Triple-Negative Breast Cancer trials in other cities

Other studies in Philadelphia

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.