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Kidney Cancer (Renal Cell Carcinoma) clinical trials in Durham, NC

12 studies for Kidney Cancer (Renal Cell Carcinoma) are looking for participants at sites in and around Durham (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Substudy 03C: A Study of Combination Therapies in Participants With Renal Cell Carcinoma With Recurrent Disease During or After Anti-PD-(L)1 Therapy (MK-3475-03C/KEYMAKER-U03)

RecruitingPhase 1/2
  • Duke Cancer Institute ( Site 5015), Durham
Ages 18 to 120 · All sexes · Updated Oct 2, 2026 · NCT07049926

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • Durham VA Medical Center, Durham
Ages 40 to 75 · All sexes · Updated Oct 2, 2026 · NCT05334069

Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors

RecruitingPhase 1
  • Exelixis Clinical Site #12, Durham
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT05176483

Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors

RecruitingPhase 2
  • UNC Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT03866382

DESTINY-PANTUMOUR04

RecruitingObservational study
  • Research Site, Durham
Ages 18 to 130 · All sexes · Updated Sep 25, 2026 · NCT07124000

Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Patients With Unresectable or Metastatic Renal Cell Cancer, SAMURAI Trial

RecruitingPhase 2
  • Duke University Medical Center, Durham
  • UNC Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT05327686

ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation

RecruitingObservational study
  • UNC- Chapel Hill, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT05059444

A Randomized Trial of Fianlimab and Cemiplimab +/- Ipilimumab or Ipilimumab Plus Nivolumab in First-line Advanced Renal Cell Carcinoma (RCC)

RecruitingPhase 2
  • University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT07188896

Testing the Addition of the Anti-Cancer Drug Tivozanib to Immunotherapy (Pembrolizumab) After Surgery to Remove All Known Sites of Kidney Cancer

RecruitingPhase 3
  • Duke University Medical Center, Durham
  • Duke Cancer Center Southpoint, Durham
  • UNC Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT06661720

Study of XmAb®819 in Subjects With Advanced Clear Cell Renal Cell Carcinoma

RecruitingPhase 1
  • Xencor Investigative Site, Durham
Ages 18 and older · All sexes · Updated Aug 3, 2026 · NCT05433142

Study With ABBV-CLS-484 in Participants With Locally Advanced or Metastatic Tumors

RecruitingPhase 1
  • Duke Cancer Center /ID# 251975, Durham
Ages 18 and older · All sexes · Updated Jun 4, 2026 · NCT04777994

A First-In Human (FIH) Study to Find Out How Well REGN10597 Medicine Given Alone or in Combination With Cemiplimab Works in Adult Participants Who Have Cancer With Tumors That Have Spread in Their Body

RecruitingPhase 1/2
  • University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Apr 28, 2026 · NCT06413680

Kidney Cancer (Renal Cell Carcinoma) trials in other cities

Other studies in Durham

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.