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Lung Cancer clinical trials in Minneapolis, MN

20 studies for Lung Cancer are looking for participants at sites in and around Minneapolis (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

RecruitingPhase 3
  • Abbott-Northwestern Hospital, Minneapolis
  • Hennepin County Medical Center, Minneapolis
  • Minneapolis VA Medical Center, Minneapolis
  • and 1 more
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT04267848

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • Abbott-Northwestern Hospital, Minneapolis
  • Hennepin County Medical Center, Minneapolis
  • Park Nicollet Clinic - Saint Louis Park, Saint Louis Park · 5 mi away
Ages 40 to 75 · All sexes · Updated Oct 2, 2026 · NCT05334069

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 2
  • Health Partners Frauenshuh Cancer Center, Saint Louis Park · 5 mi away
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06172478

Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial

RecruitingPhase 3
  • Abbott-Northwestern Hospital, Minneapolis
  • Park Nicollet Clinic - Saint Louis Park, Saint Louis Park · 5 mi away
Ages 70 and older · All sexes · Updated Oct 1, 2026 · NCT06096844

Osimertinib With or Without Bevacizumab as Initial Treatment for Patients With EGFR-Mutant Lung Cancer

RecruitingPhase 3
  • Abbott-Northwestern Hospital, Minneapolis
  • Hennepin County Medical Center, Minneapolis
  • Park Nicollet Clinic - Saint Louis Park, Saint Louis Park · 5 mi away
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT04181060

Immunotherapy After Surgery for People Who Have No Remaining Cancer Cells After Standard Treatment for Early-Stage Non-Small Cell Lung Cancer, INSIGHT Trial

RecruitingPhase 3
  • Abbott-Northwestern Hospital, Minneapolis
  • Minneapolis VA Medical Center, Minneapolis
  • Park Nicollet Clinic - Saint Louis Park, Saint Louis Park · 5 mi away
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06498635

A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)

RecruitingPhase 3
  • Allina Health Cancer Institute - Abbott Northwestern Hospital ( Site 0027), Minneapolis
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06312137

Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

RecruitingPhase 3
  • Allina Health Cancer Institute - Abbott Northwestern Hospital, Minneapolis
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07222566

This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1.

RecruitingPhase 3
  • Hennepin County Medical Center, Minneapolis
  • Metro Minnesota Community Oncology Research Consortium (MMCORC), Saint Louis Park · 5 mi away
  • Park Nicollet Frauenshuh Cancer Center, Saint Louis Park · 5 mi away
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06758401

RMT in Combination With Durvalumab + Chemo in Untreated Adenocarcinoma NSCLC. A Randomized Double Blind Phase II Trial

RecruitingPhase 2
  • Masonic Cancer Center, University of Minnesota, Minneapolis
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT04105270

Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies

RecruitingPhase 1/2
  • Masonic Cancer Center University of Minnesota, Minneapolis
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT05786924

A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

RecruitingPhase 3
  • Allina Health Cancer Institute - Abbott Northwestern Hospital, Minneapolis
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT06119581

The Vanguard Study: Testing a New Way to Screen for Cancer

RecruitingHealthy volunteers welcome
  • Minneapolis VA Medical Center, Minneapolis
Ages 45 to 75 · All sexes · Updated Sep 2, 2026 · NCT06995898

Autologous LN-145 in Patients With Metastatic Non-Small-Cell Lung Cancer

RecruitingPhase 2
  • University of Minnesota, Minneapolis
Ages 18 to 70 · All sexes · Updated Jun 26, 2026 · NCT04614103

Comparing Combinations of Targeted Drugs for Advanced Non-Small Cell Lung Cancer That Has EGFR and MET Gene Changes (A Lung-MAP Treatment Trial)

RecruitingPhase 2
  • Abbott-Northwestern Hospital, Minneapolis
  • Park Nicollet Clinic - Saint Louis Park, Saint Louis Park · 5 mi away
Ages 18 and older · All sexes · Updated Jun 3, 2026 · NCT05642572

Adding the Immunotherapy Drug Cemiplimab to Usual Treatment for People With Advanced Non-Small Cell Lung Cancer Who Had Previous Treatment With Platinum Chemotherapy and Immunotherapy (An Expanded Lung-MAP Treatment Trial)

RecruitingPhase 2/3
  • Abbott-Northwestern Hospital, Minneapolis
  • Park Nicollet Clinic - Saint Louis Park, Saint Louis Park · 5 mi away
Ages 18 and older · All sexes · Updated May 5, 2026 · NCT06616584

Axelopran for Advanced Cancer in Patients Receiving Opioids

RecruitingPhase 2
  • HealthPartners Frauenshuh Cancer Research Center, Saint Louis Park · 5 mi away
Ages 18 and older · All sexes · Updated May 5, 2026 · NCT07354919

Veterans Affairs Lung Cancer Surgery Or Stereotactic Radiotherapy

Recruiting
  • Minneapolis VA Health Care System, Minneapolis, MN, Minneapolis
Ages 18 and older · All sexes · Updated Feb 19, 2026 · NCT02984761

cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease

RecruitingObservational studyHealthy volunteers welcome
  • Allina Health Cancer Institute, Minneapolis
Ages 40 and older · All sexes · Updated Jan 20, 2026 · NCT05366881

LOTUS-CC: An Observational Research Study to Uncover Subtypes of Cancer Cachexia

RecruitingObservational study
  • Abbott-Northwestern Hospital, Minneapolis
  • Hennepin County Medical Center, Minneapolis
  • Park Nicollet Clinic - Saint Louis Park, Saint Louis Park · 5 mi away
Ages 18 and older · All sexes · Updated Jan 9, 2026 · NCT06073431

About Lung Cancer

Lung cancer forms in tissues of the lung, usually in the cells that line the air passages. It is the leading cause of cancer death in both men and women.

More about Lung Cancer on MedlinePlus

Lung Cancer trials in other cities

Other studies in Minneapolis

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.