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Heart Failure clinical trials in Minneapolis, MN

21 studies for Heart Failure are looking for participants at sites in and around Minneapolis (within about 30 miles). Open a study to see who can join and how to contact the study team.

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ELEVATE-HFpEF Clinical Study

Recruiting
  • M Health Fairview University of Minnesota Medical Center - East Bank, Minneapolis
Ages 40 and older · All sexes · Updated Oct 2, 2026 · NCT06678841

A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart

RecruitingPhase 3
  • Minneapolis VA Health Care System, Minneapolis
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06935370

A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure

RecruitingPhase 3
  • Minneapolis VA Health Care System, Minneapolis
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06424288

Alleviant ALLAY-HFrEF Study

Recruiting
  • Minneapolis Heart Institute Foundation, Minneapolis
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT06812533

Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

RecruitingPhase 3
  • University of Minnesota, Minneapolis
Ages 18 to 99 · All sexes · Updated Sep 16, 2026 · NCT07037459

Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin

RecruitingPhase 3
  • Research Site, Minneapolis
Ages 40 and older · All sexes · Updated Sep 15, 2026 · NCT06677060

A Study to Determine the Efficacy and Safety of Finerenone and SGLT2i in Combination in Hospitalized Patients With Heart Failure (CONFIRMATION-HF)

RecruitingPhase 3
  • Minneapolis, MN Investigative Site CON-10035, Minneapolis
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT06024746

A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients

RecruitingPhase 3
  • Minneapolis, MN Investigative Site 10091, Minneapolis
  • Minneapolis, MN Investigative Site 10035, Minneapolis
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT06008197

Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure

Recruiting
  • Abbott Northwestern Hospital, Minneapolis
  • University of Minnesota, Minneapolis
Ages 18 to 100 · All sexes · Updated Sep 9, 2026 · NCT06310031

Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products

RecruitingObservational study
  • Minneapolis, Minneapolis
All ages · All sexes · Updated Aug 20, 2026 · NCT00271180

LEVEL-2: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF-2

RecruitingPhase 3
  • Tenax Investigational Site, Minneapolis
Ages 18 to 85 · All sexes · Updated Aug 19, 2026 · NCT07288398

Alleviant ALLAY-HF Study

Recruiting
  • Minneapolis Heart Institute Foundation, Minneapolis
Ages 40 and older · All sexes · Updated Aug 14, 2026 · NCT05685303

CSP #2025 - Geriatric OUt-of-hospital Randomized MEal Trial in Heart Failure: Veterans Affairs (GOURMET-VA)

Recruiting
  • Minneapolis VA Health Care System, Minneapolis, MN, Minneapolis
Ages 60 and older · All sexes · Updated Aug 14, 2026 · NCT05996328

Assessment of CCM in HF With Higher Ejection Fraction

Recruiting
  • Minneapolis Heart Institute at Abbott Northwestern Hospital, Minneapolis
Ages 18 and older · All sexes · Updated Aug 6, 2026 · NCT05064709

A Study to Evaluate Finerenone on Clinical Efficacy and Safety in Patients With Heart Failure Who Are Intolerant or Not Eligible for Treatment With Steroidal Mineralocorticoid Receptor Antagonists

RecruitingPhase 3
  • Minneapolis, MN Investigative Site FIN-10035, Minneapolis
Ages 18 and older · All sexes · Updated Jul 10, 2026 · NCT06033950

PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III

Recruiting
  • University of Minnesota, Minneapolis
Ages 18 and older · All sexes · Updated Jun 29, 2026 · NCT05934487

Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure

Recruiting
  • Minneapolis Heart Institute, Minneapolis
Ages 18 and older · All sexes · Updated Jun 10, 2026 · NCT06526195

CCM OPEN HF Registry

RecruitingObservational study
  • Minneapolis Heart Institute Research Foundation, Minneapolis
Ages 18 and older · All sexes · Updated Apr 23, 2026 · NCT07112924

Secondary Mitral Regurgitation Treatment With MitraClip and Assessment by Cardiac Magnetic Resonance

RecruitingObservational study
  • Minneapolis Heart Institute Foundation, Minneapolis
Ages 18 and older · All sexes · Updated Dec 23, 2025 · NCT07131631

HF2 Registry - Hemodynamic Frontiers in Heart Failure Registry

RecruitingObservational study
  • Minneapolis Heart Institute Foundation/ Allina Health, Minneapolis
Ages 18 to 100 · All sexes · Updated May 22, 2024 · NCT06425848

About Heart Failure

Heart failure, or congestive heart failure (CHF), means the heart can't pump enough blood. Learn about the signs, symptoms, and causes.

More about Heart Failure on MedlinePlus

Heart Failure trials in other cities

Other studies in Minneapolis

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.