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Prostate Cancer clinical trials in Minneapolis, MN

22 studies for Prostate Cancer are looking for participants at sites in and around Minneapolis (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging

RecruitingPhase 3
  • Abbott-Northwestern Hospital, Minneapolis
  • Hennepin County Medical Center, Minneapolis
  • Health Partners Inc, Minneapolis
  • and 1 more
Ages 18 and older · Men · Updated Nov 13, 2026 · NCT04423211

Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors

RecruitingPhase 2
  • Hennepin County Medical Center, Minneapolis
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT03866382

The Vanguard Study: Testing a New Way to Screen for Cancer

RecruitingHealthy volunteers welcome
  • Minneapolis VA Medical Center, Minneapolis
Ages 45 to 75 · All sexes · Updated Nov 6, 2026 · NCT06995898

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • Abbott-Northwestern Hospital, Minneapolis
  • Hennepin County Medical Center, Minneapolis
  • Park Nicollet Clinic - Saint Louis Park, Saint Louis Park · 5 mi away
Ages 40 to 75 · All sexes · Updated Nov 4, 2026 · NCT05334069

A Study of JNJ-87189401 Combined With JNJ-78278343 for Advanced Prostate Cancer

RecruitingPhase 1
  • University Of Minnesota, Minneapolis
Ages 18 and older · Men · Updated Nov 3, 2026 · NCT06095089

Evaluating Prostate Cancer Patient Natural Killer Cell Function Across Racial Background and Addressing Functional Disparities With Trispecific Killer Engagers

RecruitingObservational study
  • University of Minnesota/Masonic Cancer Center, Minneapolis
Ages 18 and older · Men · Updated Nov 2, 2026 · NCT07910019

A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)

RecruitingPhase 3
  • HealthPartners Cancer Research Center-HealthPartners Frauenshuh Cancer Center ( Site 0032), Saint Louis Park · 5 mi away
Ages 18 and older · Men · Updated Oct 30, 2026 · NCT06925737

Study of JANX007 in Subjects With Metastatic Castration-Resistant Prostate Cancer (ENGAGER-PSMA-01)

RecruitingPhase 1
  • University of Minnesota Medical Center, Minneapolis
Ages 18 to 100 · Men · Updated Oct 29, 2026 · NCT05519449

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 2
  • Health Partners Frauenshuh Cancer Center, Saint Louis Park · 5 mi away
Ages 18 and older · All sexes · Updated Oct 26, 2026 · NCT06172478

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer

RecruitingPhase 3
  • Abbott-Northwestern Hospital, Minneapolis
  • Park Nicollet Clinic - Saint Louis Park, Saint Louis Park · 5 mi away
Ages 18 and older · Men · Updated Oct 23, 2026 · NCT05946213

A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)

RecruitingPhase 3
  • HealthPartners Cancer Research Center-HealthPartners Frauenshuh Cancer Center ( Site 0072), Saint Louis Park · 5 mi away
Ages 18 and older · All sexes · Updated Oct 20, 2026 · NCT06136650

A Study of Xaluritamig Plus Abiraterone Versus Investigator's Choice in Participants With Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer

RecruitingPhase 3
  • Minnesota Oncology Hematology PA, Minneapolis
  • University of Minnesota Medical Center Fairview, Minneapolis
Ages 18 and older · Men · Updated Oct 20, 2026 · NCT07213674

Phase Ib/II Platform Study of Multiple Anti-Cancer Agents in Participants With Metastatic Prostate Cancer

RecruitingPhase 1/2
  • Research Site, Minneapolis
Ages 18 to 99 · Men · Updated Oct 14, 2026 · NCT07590934

Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer

RecruitingPhase 3
  • Hennepin County Medical Center, Minneapolis
  • Health Partners Inc, Minneapolis
  • Park Nicollet Clinic - Saint Louis Park, Saint Louis Park · 5 mi away
Ages 18 and older · Men · Updated Oct 8, 2026 · NCT03678025

FOG-001 in Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2
  • M Health Fairview University of Minnesota Medical Center, Minneapolis
Ages 18 and older · All sexes · Updated Oct 7, 2026 · NCT05919264

Phase 1 Study of ACE-232 to Treat Patients With Metastatic Castration-Resistant Prostate Cancer

RecruitingPhase 1
  • M Health Fairview Clinics and Surgery Center, Minneapolis
Ages 18 and older · Men · Updated Sep 25, 2026 · NCT06801236

Carboplatin or Olaparib for BRcA Deficient Prostate Cancer

RecruitingPhase 2
  • Minneapolis VA Health Care System, Minneapolis, MN, Minneapolis
Ages 18 and older · Men · Updated Sep 17, 2026 · NCT04038502

A Study of Talazoparib With or Without Enzalutamide in People With Prostate Cancer Who Have Previously Received Abiraterone Acetate or Darolutamide

RecruitingPhase 2
  • Masonic Cancer Center, Minneapolis
Ages 18 and older · Men · Updated Aug 21, 2026 · NCT06844383

Study of ORIC-944 in Patients With Metastatic Prostate Cancer

RecruitingPhase 1
  • Minnesota Oncology Hematology, Minneapolis
Ages 18 and older · Men · Updated Jul 9, 2026 · NCT05413421

Axelopran for Advanced Cancer in Patients Receiving Opioids

RecruitingPhase 2
  • HealthPartners Frauenshuh Cancer Research Center, Saint Louis Park · 5 mi away
Ages 18 and older · All sexes · Updated May 5, 2026 · NCT07354919

Testing Whether the Addition of Carboplatin Chemotherapy to Cabazitaxel Chemotherapy Will Improve Outcomes Compared to Cabazitaxel Alone in People With Castrate-Resistant Prostate Cancer That Has Spread Beyond the Prostate to Other Parts of the Body

RecruitingPhase 3
  • Abbott-Northwestern Hospital, Minneapolis
  • Hennepin County Medical Center, Minneapolis
  • Health Partners Inc, Minneapolis
  • and 1 more
Ages 18 and older · Men · Updated Jan 22, 2026 · NCT06470243

Vitamin D for Prostate Endocrine Therapy

RecruitingPhase 3
  • Park Nicollet Clinic - Saint Louis Park, Saint Louis Park · 5 mi away
Ages 50 and older · Men · Updated Jan 15, 2026 · NCT05838716

About Prostate Cancer

Prostate cancer is one of the most common types of cancer among American men. The risk goes up as men age. Learn about symptoms, tests, and treatment.

More about Prostate Cancer on MedlinePlus

Prostate Cancer trials in other cities

Other studies in Minneapolis

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.