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Breast Cancer clinical trials in Minneapolis, MN

27 studies for Breast Cancer are looking for participants at sites in and around Minneapolis (within about 30 miles). Open a study to see who can join and how to contact the study team.

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 2
  • Health Partners Frauenshuh Cancer Center, Saint Louis Park · 5 mi away
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06172478

ASPEN-09-03: A Study of Evorpacept in Combination With Trastuzumab and Chemotherapy in Metastatic HER2-Positive Breast Cancer

RecruitingPhase 2
  • HealthPartners Frauenshuh Cancer Center, Saint Louis Park · 5 mi away
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07007559

Phase IIIb Study of Ribociclib + ET in Early Breast Cancer

RecruitingPhase 3
  • Minnesota Oncology Hematology P A, Minneapolis
  • Allina Hlth Cancer Inst Minneapolis, Minneapolis
Ages 18 to 100 · All sexes · Updated Sep 23, 2026 · NCT05827081

Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast Cancer

RecruitingPhase 3
  • Clinical Trial Site, Minneapolis
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07085767

A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

RecruitingPhase 3
  • Allina Health Cancer Institute - Abbott Northwestern Hospital, Minneapolis
  • Metro-Minnesota Community Clinical Oncology, Saint Louis Park · 5 mi away
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07174336

ROSETTA Breast-01: The Effects and Safety of Pumitamig in Patients With Triple-Negative Breast Cancer

RecruitingPhase 3
  • Healthpartners Regions Specialty Clinics, Saint Louis Park · 5 mi away
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07173751

A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence

RecruitingPhase 3
  • Allina Health Cancer Institute - Abbott Northwestern Hospital, Minneapolis
  • Metro-MN Comm. Onc. Res Consortium, Saint Louis Park · 5 mi away
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT06492616

Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer

RecruitingPhase 3
  • Minnesota Oncology Hematology, P.A., Minneapolis
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT06982521

Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

RecruitingPhase 3
  • Abbott-Northwestern Hospital, Minneapolis
  • Hennepin County Medical Center, Minneapolis
  • Park Nicollet Clinic - Saint Louis Park, Saint Louis Park · 5 mi away
Ages 18 to 60 · Women · Updated Sep 2, 2026 · NCT05879926

PRE-ISPY Phase I/II Oncology Platform Program

RecruitingPhase 1/2
  • University of Minnesota Masonic Cancer Center, Minneapolis
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT05868226

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • Abbott-Northwestern Hospital, Minneapolis
  • Hennepin County Medical Center, Minneapolis
  • Park Nicollet Clinic - Saint Louis Park, Saint Louis Park · 5 mi away
Ages 40 to 75 · All sexes · Updated Sep 2, 2026 · NCT05334069

The Vanguard Study: Testing a New Way to Screen for Cancer

RecruitingHealthy volunteers welcome
  • Minneapolis VA Medical Center, Minneapolis
Ages 45 to 75 · All sexes · Updated Sep 2, 2026 · NCT06995898

FT836 With or Without Chemotherapy and/or Monoclonal Antibodies, in Participants With Advanced Solid Tumors

RecruitingPhase 1
  • University of Minnesota Masonic Cancer Center, Minneapolis
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT07216105

A Study of Alisertib in Combination With Endocrine Therapy in Patients With HR-positive, HER2-negative Recurrent or Metastatic Breast Cancer

RecruitingPhase 2
  • University of Minnesota, Masonic Cancer Center, Minneapolis
Ages 18 and older · All sexes · Updated Jul 27, 2026 · NCT06369285

Fast-Her: Fasting Effects on Breast Cancer Treatment

Recruiting
  • University of Minnesota, Minneapolis
Ages 18 and older · All sexes · Updated Jul 13, 2026 · NCT07624617

Evaluation of Lasofoxifene Combined With Abemaciclib Compared With Fulvestrant Combined With Abemaciclib in Locally Advanced or Metastatic ER+/HER2- Breast Cancer With an ESR1 Mutation

RecruitingPhase 3
  • Allina Health System DBA Virginia Piper Cancer Institute, Minneapolis
Ages 18 and older · All sexes · Updated Jun 22, 2026 · NCT05696626

I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer

RecruitingPhase 2
  • University of Minnesota, Minneapolis
  • Metro Minnesota Community Oncology Research Consortium, Hennepin County Medical Center, Saint Louis Park · 5 mi away
Ages 18 and older · All sexes · Updated May 6, 2026 · NCT01042379

Axelopran for Advanced Cancer in Patients Receiving Opioids

RecruitingPhase 2
  • HealthPartners Frauenshuh Cancer Research Center, Saint Louis Park · 5 mi away
Ages 18 and older · All sexes · Updated May 5, 2026 · NCT07354919

De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

RecruitingPhase 3
  • Abbott-Northwestern Hospital, Minneapolis
  • Park Nicollet Clinic - Saint Louis Park, Saint Louis Park · 5 mi away
Ages 50 to 70 · All sexes · Updated Apr 23, 2026 · NCT04852887

Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics

RecruitingObservational study
  • Abbott-Northwestern Hospital, Minneapolis
  • Hennepin County Medical Center, Minneapolis
  • Park Nicollet Clinic - Saint Louis Park, Saint Louis Park · 5 mi away
Ages 18 and older · All sexes · Updated Mar 17, 2026 · NCT06418204

cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease

RecruitingObservational studyHealthy volunteers welcome
  • Allina Health Cancer Institute, Minneapolis
Ages 40 and older · All sexes · Updated Jan 20, 2026 · NCT05366881

EXActDNA-003 / NSABP B-64: Study of Molecular Residual Disease Detection in Breast Cancer (MRD)

RecruitingObservational study
  • Metro Minnesota Community Oncology Consortium (MMCORC), Saint Louis Park · 5 mi away
Ages 18 and older · All sexes · Updated Jan 20, 2026 · NCT06401421

S1501 Dual Observational and Randomized Cohort Study of Patients With Metastatic HER-2+ Breast Cancer at Risk of Cardiac Toxicity

RecruitingPhase 3
  • Abbott-Northwestern Hospital, Minneapolis
  • Hennepin County Medical Center, Minneapolis
  • Park Nicollet Clinic - Saint Louis Park, Saint Louis Park · 5 mi away
Ages 18 and older · All sexes · Updated Oct 8, 2025 · NCT03418961

MammaPrint, BluePrint, and Full-genome Data Linked With Clinical Data to Evaluate New Gene EXpression Profiles

RecruitingObservational study
  • Minnesota Oncology, Minneapolis
Ages 18 and older · All sexes · Updated Aug 20, 2025 · NCT03053193

About Breast Cancer

Breast cancer is a cancer that starts in the breast tissue, when cells change and grow out of control. These extra cells can form a mass called a tumor.

More about Breast Cancer on MedlinePlus

Breast Cancer trials in other cities

Other studies in Minneapolis

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.