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Breast Cancer clinical trials in Minneapolis, MN

23 studies for Breast Cancer are looking for participants at sites in and around Minneapolis (within about 30 miles). Open a study to see who can join and how to contact the study team.

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S1501 Dual Observational and Randomized Cohort Study of Patients With Metastatic HER-2+ Breast Cancer at Risk of Cardiac Toxicity

RecruitingPhase 3
  • Abbott-Northwestern Hospital, Minneapolis
  • Hennepin County Medical Center, Minneapolis
  • Park Nicollet Clinic - Saint Louis Park, Saint Louis Park · 5 mi away
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT03418961

ASPEN-09-03: A Study of Evorpacept in Combination With Trastuzumab and Chemotherapy in Metastatic HER2-Positive Breast Cancer

RecruitingPhase 2
  • HealthPartners Frauenshuh Cancer Center, Saint Louis Park · 5 mi away
Ages 18 and older · All sexes · Updated Nov 9, 2026 · NCT07007559

The Vanguard Study: Testing a New Way to Screen for Cancer

RecruitingHealthy volunteers welcome
  • Minneapolis VA Medical Center, Minneapolis
Ages 45 to 75 · All sexes · Updated Nov 6, 2026 · NCT06995898

Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer

RecruitingPhase 3
  • Minnesota Oncology Hematology, P.A., Minneapolis
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT06982521

A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

RecruitingPhase 3
  • Allina Health Cancer Institute - Abbott Northwestern Hospital, Minneapolis
  • Metro-Minnesota Community Clinical Oncology, Saint Louis Park · 5 mi away
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07174336

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • Abbott-Northwestern Hospital, Minneapolis
  • Hennepin County Medical Center, Minneapolis
  • Park Nicollet Clinic - Saint Louis Park, Saint Louis Park · 5 mi away
Ages 40 to 75 · All sexes · Updated Nov 4, 2026 · NCT05334069

Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics

RecruitingObservational study
  • Abbott-Northwestern Hospital, Minneapolis
  • Hennepin County Medical Center, Minneapolis
  • Park Nicollet Clinic - Saint Louis Park, Saint Louis Park · 5 mi away
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT06418204

Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

RecruitingPhase 3
  • Abbott-Northwestern Hospital, Minneapolis
  • Hennepin County Medical Center, Minneapolis
  • Park Nicollet Clinic - Saint Louis Park, Saint Louis Park · 5 mi away
Ages 18 to 60 · Women · Updated Nov 4, 2026 · NCT05879926

ROSETTA Breast-01: The Effects and Safety of Pumitamig in Patients With Triple-Negative Breast Cancer

RecruitingPhase 3
  • Healthpartners Regions Specialty Clinics, Saint Louis Park · 5 mi away
Ages 18 and older · All sexes · Updated Oct 30, 2026 · NCT07173751

EXActDNA-003 / NSABP B-64: Study of Molecular Residual Disease Detection in Breast Cancer (MRD)

RecruitingObservational study
  • Metro Minnesota Community Oncology Consortium (MMCORC), Saint Louis Park · 5 mi away
Ages 18 and older · All sexes · Updated Oct 27, 2026 · NCT06401421

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 2
  • Health Partners Frauenshuh Cancer Center, Saint Louis Park · 5 mi away
Ages 18 and older · All sexes · Updated Oct 26, 2026 · NCT06172478

A Study of Alisertib in Combination With Endocrine Therapy in Patients With HR-positive, HER2-negative Recurrent or Metastatic Breast Cancer

RecruitingPhase 2
  • University of Minnesota, Masonic Cancer Center, Minneapolis
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06369285

PRE-ISPY Phase I/II Oncology Platform Program

RecruitingPhase 1/2
  • University of Minnesota Masonic Cancer Center, Minneapolis
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT05868226

Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast Cancer

RecruitingPhase 3
  • Clinical Trial Site, Minneapolis
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07085767

FT836 With or Without Chemotherapy and/or Monoclonal Antibodies, in Participants With Advanced Solid Tumors

RecruitingPhase 1
  • University of Minnesota Masonic Cancer Center, Minneapolis
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT07216105

Fast-Her: Fasting Effects on Breast Cancer Treatment

Recruiting
  • University of Minnesota, Minneapolis
Ages 18 and older · All sexes · Updated Jul 13, 2026 · NCT07624617

I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer

RecruitingPhase 2
  • University of Minnesota, Minneapolis
  • Metro Minnesota Community Oncology Research Consortium, Hennepin County Medical Center, Saint Louis Park · 5 mi away
Ages 18 and older · All sexes · Updated May 6, 2026 · NCT01042379

Axelopran for Advanced Cancer in Patients Receiving Opioids

RecruitingPhase 2
  • HealthPartners Frauenshuh Cancer Research Center, Saint Louis Park · 5 mi away
Ages 18 and older · All sexes · Updated May 5, 2026 · NCT07354919

De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

RecruitingPhase 3
  • Abbott-Northwestern Hospital, Minneapolis
  • Park Nicollet Clinic - Saint Louis Park, Saint Louis Park · 5 mi away
Ages 50 to 70 · All sexes · Updated Apr 23, 2026 · NCT04852887

MammaPrint, BluePrint, and Full-genome Data Linked With Clinical Data to Evaluate New Gene EXpression Profiles

RecruitingObservational study
  • Minnesota Oncology, Minneapolis
Ages 18 and older · All sexes · Updated Aug 20, 2025 · NCT03053193

About Breast Cancer

Breast cancer is a cancer that starts in the breast tissue, when cells change and grow out of control. Learn about the types, diagnosis, and treatments.

More about Breast Cancer on MedlinePlus

Breast Cancer trials in other cities

Other studies in Minneapolis

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.