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Melanoma clinical trials in Nashville, TN

33 studies for Melanoma are looking for participants at sites in and around Nashville (within about 30 miles). Open a study to see who can join and how to contact the study team.

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Phase 1/2 Study of Intravenous Injection of STX-003 in Advanced Solid Tumors as Monotherapy or in Combination With Pembrolizumab

RecruitingPhase 1/2
  • Sarah Cannon Research Institute, Nashville
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT07751042

A Phase 1 Study of PLN-101095 in Adults With Advanced or Metastatic Solid Tumors

RecruitingPhase 1
  • Tennessee Oncology, Nashville
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06270706

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 2
  • SCRI Oncology Partners, Nashville
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06172478

A Study of BI 3810944 in Patients With Advanced Cancer

RecruitingPhase 1
  • Tennessee Oncology, PLLC - Elliston Place Plaza DDU, Nashville
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT07224425

Phase 1 Study of PF-08046033 in Advanced Solid Tumors

RecruitingPhase 1
  • Sarah Cannon Research Institute- Pharmacy, Nashville
  • SCRI Oncology Partners, Nashville
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07519655

DESTINY-PANTUMOUR04

RecruitingObservational study
  • Research Site, Nashville
Ages 18 to 130 · All sexes · Updated Sep 25, 2026 · NCT07124000

A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma (Harmony Head-to-Head)

RecruitingPhase 3
  • Sarah Cannon Research Institute (SCRI) Oncology Partners, Nashville
  • Tennessee Oncology, Nashville
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06246916

Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.

RecruitingPhase 3
  • SCRI Oncology Partners, Nashville
Ages 18 to 70 · All sexes · Updated Sep 24, 2026 · NCT05727904

Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis

RecruitingPhase 1/2
  • Vanderbilt University Medical Center, Nashville
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT06047379

Comparing the Effectiveness of Less Invasive Procedures With the Current Standard of Care for the Treatment of Older Adults With Early-Stage Melanoma

RecruitingPhase 3
  • Vanderbilt University/Ingram Cancer Center, Nashville
Ages 75 and older · All sexes · Updated Sep 24, 2026 · NCT07068074

Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer

RecruitingPhase 1/2
  • Sarah Cannon Research Institute, Nashville
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT05267626

R-5780-01 In Combination With PD-1 Checkpoint Inhibitors (Checkpoint Protein on Immune Cells Called T Cells) in Patients With Solid Tumors

RecruitingPhase 1
  • Sarah Cannon Research Institute, Nashville
Ages 18 to 80 · All sexes · Updated Sep 18, 2026 · NCT06398418

Study of AMXT 1501 and DFMO in Combination With Standard Therapies in Advanced Solid Tumors

RecruitingPhase 1/2
  • Sarah Cannon Research Institute Oncology Partners, Nashville
  • Vanderbilt-Ingram Cancer Institute, Nashville
Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT07287917

A Study to Evaluate KIN-2787 in Participants With BRAF and/or NRAS Mutation Positive Solid Tumors

RecruitingPhase 1
  • Sarah Cannon Research Institute-Tennessee Oncology, Nashville
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT04913285

Project: Every Child for Younger Patients With Cancer

RecruitingObservational study
  • The Children's Hospital at TriStar Centennial, Nashville
  • Vanderbilt University/Ingram Cancer Center, Nashville
Up to age 25 · All sexes · Updated Aug 25, 2026 · NCT02402244

A Study of BMS-986340 as Monotherapy and as Combination Therapy in Participants With Advanced Solid Tumors

RecruitingPhase 1/2
  • Vanderbilt University Medical Center, Nashville
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT04895709

Safety and Tolerability Study of GIM-531 in Advanced Solid Tumors

RecruitingPhase 1/2
  • Tennessee Oncology, PLLC, Nashville
Ages 18 and older · All sexes · Updated Aug 14, 2026 · NCT06425926

A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors

RecruitingPhase 1/2
  • Sarah Cannon Research Institute Oncology Partners (SCRI-Nashville), Nashville
Ages 18 and older · All sexes · Updated Aug 11, 2026 · NCT05592626

A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects With Recurrent or Metastatic Solid Tumors (IDeate-PanTumor02)

RecruitingPhase 1/2
  • SCRI Oncology Partners, Nashville
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT06330064

A Phase 1 of CTX-8371 in Patients With Advanced Malignancies

RecruitingPhase 1
  • Tennessee Oncology, Nashville
Ages 18 and older · All sexes · Updated Jul 28, 2026 · NCT06150664

A Study to Investigate the Safety and Efficacy of IOV-3001 in Adults With Advanced Melanoma Who Will Receive Lifileucel

RecruitingPhase 1/2
  • Sarah Cannon Research Institute, Nashville
Ages 18 to 70 · All sexes · Updated Jun 15, 2026 · NCT06940739

Study of IDE196 in Patients With Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusions

RecruitingPhase 1/2
  • The Sarah Cannon Research Institute/Tennessee Oncology, Nashville
Ages 18 and older · All sexes · Updated Jun 8, 2026 · NCT03947385

Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS

RecruitingPhase 1/2
  • Sarah Cannon Research Institute, Nashville
Ages 18 and older · All sexes · Updated May 15, 2026 · NCT05379985

Pilot Study of Bone Mineral Density Changes During Anti-PD-1 Immunotherapy

Recruiting
  • Vanderbilt-Ingram Cancer Center, Nashville
Ages 18 and older · All sexes · Updated May 6, 2026 · NCT07555210

Neoadjuvant Darovasertib in Primary Uveal Melanoma

RecruitingPhase 3
  • SCRI Oncology Partners, Nashville
  • Vanderbilt Eye Institute, Nashville
Ages 18 and older · All sexes · Updated May 6, 2026 · NCT07015190

A Study to Investigate the Safety and Efficacy of NST-628 Oral Tablets in Subjects With Solid Tumors

RecruitingPhase 1
  • SCRI Oncology Partners, Nashville
  • Vanderbilt-Ingram Cancer Center, Nashville
Ages 18 and older · All sexes · Updated Apr 20, 2026 · NCT06326411

A Randomized, Phase 2/3 Study to Investigate the Efficacy and Safety of RP2 in Combination With Nivolumab in Immune Checkpoint Inhibitor-Naïve Adult Patients With Metastatic Uveal Melanoma

RecruitingPhase 2/3
  • Sarah Cannon Research Institute, Nashville
  • Vanderbilt Ingram Cancer Center (Henry-Joyce Cancer Clinic), Nashville
All ages · All sexes · Updated Apr 2, 2026 · NCT06581406

Nilotinib Plus Dabrafenib/Trametinib or Encorafenib/Binimetinib in Metastatic Melanoma

RecruitingPhase 1
  • Vanderbilt-Ingram Cancer Center, Nashville
Ages 18 and older · All sexes · Updated Feb 13, 2026 · NCT04903119

A Phase 1/2a Study of DB-1311/BNT324 in Advanced/Metastatic Solid Tumors

RecruitingPhase 1/2
  • Research Site 136, Nashville
Ages 18 and older · All sexes · Updated Nov 21, 2025 · NCT05914116

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Nashville
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

Storage and Research Use of Human Bio-specimens From Melanoma Patients and Clinical Testing for Assignment of Treatment

RecruitingObservational study
  • Vanderbitl-Ingram Cancer Center, Nashville
Ages 18 and older · All sexes · Updated Sep 19, 2025 · NCT01205815

A Study Assessing KB707 for the Treatment of Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2
  • Sarah Cannon Research Institute, Nashville
Ages 18 and older · All sexes · Updated May 18, 2025 · NCT05970497

A Study of GV20-0251 Monotherapy and GV20-0251 in Combination With Pembrolizumab in Participants With Solid Tumor Malignancies

RecruitingPhase 1/2
  • Verdi Oncology Tennessee, Scri Oncology Partners, Nashville
Ages 18 and older · All sexes · Updated Feb 13, 2025 · NCT05669430

About Melanoma

Melanoma is the most serious type of skin cancer. Most have a black or black-blue area. Learn the 'ABCDE' of what to watch for and treatment options.

More about Melanoma on MedlinePlus

Melanoma trials in other cities

Other studies in Nashville

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.