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Melanoma clinical trials in Columbus, OH

21 studies for Melanoma are looking for participants at sites in and around Columbus (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • Ohio State University Comprehensive Cancer Center, Columbus
  • Mount Carmel East Hospital, Columbus
  • The Mark H Zangmeister Center, Columbus
  • and 8 more
Ages 40 to 75 · All sexes · Updated Oct 2, 2026 · NCT05334069

A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma (Harmony Head-to-Head)

RecruitingPhase 3
  • The Ohio State University Wexner Medical Center, Columbus
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06246916

Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.

RecruitingPhase 3
  • Ohio State University, Columbus
Ages 18 to 70 · All sexes · Updated Sep 24, 2026 · NCT05727904

Comparing the Effectiveness of Less Invasive Procedures With the Current Standard of Care for the Treatment of Older Adults With Early-Stage Melanoma

RecruitingPhase 3
  • Ohio State University Comprehensive Cancer Center, Columbus
Ages 75 and older · All sexes · Updated Sep 24, 2026 · NCT07068074

Personalized Cancer Vaccine (PCV) Strategy in Patients With Solid Tumors and Molecular Residual Disease

RecruitingPhase 1
  • Ohio State University, Columbus
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT06529822

A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases

RecruitingPhase 2
  • Ohio State University Comprehensive Cancer Center, Columbus
  • Mount Carmel East Hospital, Columbus
  • Columbus Oncology and Hematology Associates Inc, Columbus
  • and 15 more
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT04511013

Project: Every Child for Younger Patients With Cancer

RecruitingObservational study
  • Nationwide Children's Hospital, Columbus
  • Ohio State University Comprehensive Cancer Center, Columbus
Up to age 25 · All sexes · Updated Aug 25, 2026 · NCT02402244

A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors

RecruitingPhase 1/2
  • The Ohio State University Comprehensive Cancer Center, Columbus
Ages 18 and older · All sexes · Updated Aug 11, 2026 · NCT05592626

Intralesional Influenza Vaccine for the Treatment of Stage I-IV Melanoma

RecruitingPhase 1
  • Ohio State University Comprehensive Cancer Center, Columbus
Ages 18 to 99 · All sexes · Updated Jul 13, 2026 · NCT04697576

Natural Killer Cell Therapy (UD TGFbetai NK Cells) and Temozolomide for the Treatment of Stage IV Melanoma Metastatic to the Brain

RecruitingPhase 1/2
  • Ohio State University Comprehensive Cancer Center, Columbus
Ages 18 and older · All sexes · Updated Jun 11, 2026 · NCT05588453

ACTengine® IMA203/IMA203CD8 as Monotherapy or in Combination With Nivolumab in Recurrent and/or Refractory Solid Tumors

RecruitingPhase 1/2
  • Ohio State University Wexner Medical Center Gynecologic Oncology at Mill Run, Columbus
Ages 18 and older · All sexes · Updated May 13, 2026 · NCT03686124

Neoadjuvant Darovasertib in Primary Uveal Melanoma

RecruitingPhase 3
  • Ohio State Eye and Ear Institute, Columbus
Ages 18 and older · All sexes · Updated May 6, 2026 · NCT07015190

Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics

RecruitingObservational study
  • Memorial Hospital, Marysville · 27 mi away
Ages 18 and older · All sexes · Updated Mar 17, 2026 · NCT06418204

EMLA Topical Cream for Treatment of Pain in Patients Receiving Intra-Dermal Technetium 99 Injections for Lymphoscintigraphy for Skin Cancers

RecruitingPhase 2
  • Ohio State University Comprehensive Cancer Center, Columbus
Ages 18 to 99 · All sexes · Updated Mar 10, 2026 · NCT06223659

Frequency and Clinical Phenotype of BAP1 Hereditary Predisposition Syndrome

RecruitingObservational studyHealthy volunteers welcome
  • The Ohio State University Wexner Medical Center, Columbus
All ages · All sexes · Updated Mar 9, 2026 · NCT04792463

Tebentafusp Regimen Versus Investigator's Choice in Previously Treated Advanced Melanoma (TEBE-AM)

RecruitingPhase 3
  • The Ohio State University Comprehensive Cancer Center, Columbus
Ages 18 and older · All sexes · Updated Feb 25, 2026 · NCT05549297

A Storage Facility for Tissues Obtained From Patients With Malignant Melanoma

RecruitingObservational studyHealthy volunteers welcome
  • Ohio State University Comprehensive Cancer Center, Columbus
All ages · All sexes · Updated Feb 17, 2026 · NCT04567706

Efficacy of Daromun Neoadjuvant Intratumoral Treatment in Clinical Stage IIIB/C/D Melanoma Patients

RecruitingPhase 3
  • Ohio State University Wexner Medical Center, Columbus
Ages 18 and older · All sexes · Updated Dec 17, 2025 · NCT03567889

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Columbus
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma

Recruiting
  • Ohio State University Comprehensive Cancer Center, Columbus
Ages 18 and older · All sexes · Updated Nov 27, 2024 · NCT03860883

About Melanoma

Melanoma is the most serious type of skin cancer. Most have a black or black-blue area. Learn the 'ABCDE' of what to watch for and treatment options.

More about Melanoma on MedlinePlus

Melanoma trials in other cities

Other studies in Columbus

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.