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Treatment-Resistant Depressive Disorder clinical trials in San Diego, CA

10 studies for Treatment-Resistant Depressive Disorder are looking for participants at sites in and around San Diego (within about 30 miles). Open a study to see who can join and how to contact the study team.

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ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response

RecruitingPhase 2
  • Kadima Neuropsychiatry Institute, La Jolla · 11 mi away
Ages 18 to 65 · All sexes · Updated Oct 5, 2026 · NCT07284667

A Study of Esketamine Nasal Spray Versus Placebo Spray in Adult Participants With Treatment-resistant Depression

RecruitingPhase 3
  • Artemis Institute for Clinical Research, San Diego
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07716098

Spaced Transcranial Direct Current Stimulation for Treatment-Resistant Depression: A Home-Based Feasibility and Safety Study

Recruiting
  • UCSD Interventional Psychiatry, San Diego
Ages 18 to 85 · All sexes · Updated Sep 15, 2026 · NCT07217223

A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)

RecruitingPhase 2
  • Kadima Neuropsychiatry Institute, La Jolla · 11 mi away
Ages 18 to 65 · All sexes · Updated May 11, 2026 · NCT06524830

Mindfulness Engaged Neurostimulation for Depression (MEND II)

RecruitingPhase 2
  • UC San Diego Health Psychiatry, San Diego
Ages 18 to 65 · All sexes · Updated May 6, 2026 · NCT07512284

Maintenance rTMS for Depression (Maitr-De)

Recruiting
  • University of California, San Diego, San Diego
Ages 18 to 80 · All sexes · Updated Apr 29, 2026 · NCT06938841

ALTO-207 in Adults With Treatment-resistant Depression (TRD)

RecruitingPhase 2
  • Site 7144, San Diego
Ages 18 to 75 · All sexes · Updated Apr 28, 2026 · NCT07553637

ATLAS-1: Advanced Trial for Longitudinal Assessment in Salma 1

RecruitingObservational study
  • Salma Health, La Jolla · 11 mi away
Ages 18 and older · All sexes · Updated Apr 14, 2026 · NCT07528014

Treatment-Resistant Depressive Disorder trials in other cities

Other studies in San Diego

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.