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Breast Cancer clinical trials in Cincinnati, OH

24 studies for Breast Cancer are looking for participants at sites in and around Cincinnati (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

S1501 Dual Observational and Randomized Cohort Study of Patients With Metastatic HER-2+ Breast Cancer at Risk of Cardiac Toxicity

RecruitingPhase 3
  • The Christ Hospital, Cincinnati
  • University of Cincinnati Cancer Center-UC Medical Center, Cincinnati
  • University of Cincinnati Cancer Center-West Chester, West Chester · 15 mi away
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT03418961

A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)

RecruitingPhase 3
  • Good Samaritan Hospital-TriHealth Cancer institute ( Site 0027), Cincinnati
Ages 18 and older · All sexes · Updated Nov 10, 2026 · NCT06966700

A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

RecruitingPhase 3
  • Saint Elizabeth Medical Center Edgewood, Edgewood · 8 mi away
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07174336

E-Mindfulness Approaches for Living After Breast Cancer

RecruitingPhase 3
  • University of Cincinnati Cancer Center-UC Medical Center, Cincinnati
  • University of Cincinnati Cancer Center-West Chester, West Chester · 15 mi away
Ages 18 to 50 · All sexes · Updated Nov 4, 2026 · NCT06748222

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • Good Samaritan Hospital - Cincinnati, Cincinnati
  • Oncology Hematology Care Inc-Kenwood, Cincinnati
  • Bethesda North Hospital, Cincinnati
  • and 3 more
Ages 40 to 75 · All sexes · Updated Nov 4, 2026 · NCT05334069

Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

RecruitingPhase 3
  • The Christ Hospital, Cincinnati
  • Good Samaritan Hospital - Cincinnati, Cincinnati
  • Bethesda North Hospital, Cincinnati
  • and 2 more
Ages 18 to 60 · Women · Updated Nov 4, 2026 · NCT05879926

A Clinical Study of Patritumab Deruxtecan to Treat Breast Cancer (MK-1022-016)

RecruitingPhase 3
  • TriHealth Cancer Institute-Good Samaritan Hospital ( Site 0020), Cincinnati
Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT07060807

The CDK4/6 Inhibitor Dosing Knowledge (CDK) Study

RecruitingPhase 3
  • University of Cincinnati Medical Center, Cincinnati
  • University of Cincinnati Medical Center - West Chester Hospital, West Chester · 15 mi away
Ages 60 and older · All sexes · Updated Nov 2, 2026 · NCT06377852

A Phase 1 Study of LNCB74 in Advanced Solid Tumors

RecruitingPhase 1
  • St. Elizabeth Healthcare, Edgewood · 8 mi away
Ages 18 and older · All sexes · Updated Oct 29, 2026 · NCT06774963

EXActDNA-003 / NSABP B-64: Study of Molecular Residual Disease Detection in Breast Cancer (MRD)

RecruitingObservational study
  • St. Elizabeth Edgewood Hospital, Edgewood · 8 mi away
Ages 18 and older · All sexes · Updated Oct 27, 2026 · NCT06401421

Study of AMXT 1501 and DFMO in Combination With Standard Therapies in Advanced Solid Tumors

RecruitingPhase 1/2
  • University of Cincinnati Medical Center, Cincinnati
Ages 18 and older · All sexes · Updated Oct 22, 2026 · NCT07287917

A Phase IIIb Study to Evaluate Camizestrant Plus Ribociclib in ER-positive, HER2-negative Advanced Breast Cancer

RecruitingPhase 3
  • Research Site, Edgewood · 8 mi away
Ages 18 to 130 · All sexes · Updated Oct 19, 2026 · NCT07647328

A Study of Sacituzumab Tirumotecan (MK-2870) as a Single Agent and in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer (MK-2870-010)

RecruitingPhase 3
  • Saint Elizabeth Medical Center Edgewood-Cancer Care Center ( Site 0053), Edgewood · 8 mi away
Ages 18 and older · All sexes · Updated Oct 13, 2026 · NCT06312176

Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast Cancer

RecruitingPhase 3
  • Clinical Trial Site, Cincinnati
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07085767

Evaluating Minimal Residual Disease (MRD) Through Longitudinal Circulating Tumor DNA (ctDNA) Profiling in Breast Malignancies

RecruitingObservational study
  • University of Cincinnati Medical Center, Cincinnati
Ages 18 to 99 · All sexes · Updated Sep 3, 2026 · NCT07211178

Phase 3 Study to Evaluate the Efficacy and Safety of HER2/Neu Peptide GLSI-100 (GP2 + GM-CSF) in HER2/Neu Positive Subjects

RecruitingPhase 3
  • Oncology Hematology Care, Cincinnati
Ages 18 to 100 · All sexes · Updated Aug 6, 2026 · NCT05232916

Intraoperative Neuromonitoring (IONM) and Bipolar Electrocautery (BE) During Axillary Lymph Node Dissection (ALND)

Recruiting
  • University of Cincinnati, Cincinnati
Ages 18 to 70 · All sexes · Updated Jul 1, 2026 · NCT07528638

Sacituzumab Govitecan +/- Pembrolizumab in Metastatic TNBC

RecruitingPhase 2
  • The Christ Hospital Cancer Center, Cincinnati
Ages 18 and older · All sexes · Updated Apr 29, 2026 · NCT04468061

De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

RecruitingPhase 3
  • University of Cincinnati Cancer Center-UC Medical Center, Cincinnati
  • University of Cincinnati Cancer Center-West Chester, West Chester · 15 mi away
Ages 50 to 70 · All sexes · Updated Apr 23, 2026 · NCT04852887

A Study of DB-1310 in Advanced/Metastatic Solid Tumors

RecruitingPhase 1/2
  • Carl & Edyth Lindner Center for Research & Education at The Christ Hospital and The Christ Hospital Cancer Center, Cincinnati
Ages 18 and older · All sexes · Updated Apr 6, 2026 · NCT05785741

Post-mastectomy Recovery: Comparing Preoperative PECS-II Blocks With Intraoperative Pectoral Blocks

RecruitingPhase 4
  • University of Cincinnati Medical Center, Cincinnati
Ages 18 and older · All sexes · Updated Nov 4, 2025 · NCT06574022

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Cincinnati
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

MammaPrint, BluePrint, and Full-genome Data Linked With Clinical Data to Evaluate New Gene EXpression Profiles

RecruitingObservational study
  • TriHealth Cancer Institutes, Cincinnati
  • Oncology Hematology Care, Cincinnati
Ages 18 and older · All sexes · Updated Aug 20, 2025 · NCT03053193

About Breast Cancer

Breast cancer is a cancer that starts in the breast tissue, when cells change and grow out of control. Learn about the types, diagnosis, and treatments.

More about Breast Cancer on MedlinePlus

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Other studies in Cincinnati

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.