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Prostate Cancer clinical trials in Charleston, SC

15 studies for Prostate Cancer are looking for participants at sites in and around Charleston (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors

RecruitingPhase 2
  • Medical University of South Carolina, Charleston
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT03866382

A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)

RecruitingPhase 3
  • Ralph H. Johnson VA Health Care System (RHJVAHCS)-Urology ( Site 0083), Charleston
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06136650

Study Comparing AAA817+ARPI Versus Standard of Care in Adult Participants With PSMA-positive mCRPC

RecruitingPhase 3
  • MUSC Hollings Cancer Center, Charleston
Ages 18 to 100 · Men · Updated Sep 22, 2026 · NCT06855277

High Dose Testosterone for ATM, CDK12 or CHEK2 Altered Prostate Cancers

RecruitingPhase 2
  • Ralph H. Johnson VA Medical Center, Charleston, SC, Charleston
Ages 18 and older · Men · Updated Sep 17, 2026 · NCT05011383

Study of JANX014 in Subjects With Metastatic Castration-Resistant Prostate Cancer

RecruitingPhase 1
  • Medical University of South Carolina - Hollings Cancer Center, Charleston
Ages 18 and older · Men · Updated Sep 3, 2026 · NCT07545811

Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging

RecruitingPhase 3
  • Medical University of South Carolina, Charleston
Ages 18 and older · Men · Updated Aug 19, 2026 · NCT04423211

Study of JANX007 in Subjects With Metastatic Castration-Resistant Prostate Cancer (ENGAGER-PSMA-01)

RecruitingPhase 1
  • Medical University of South Carolina, Charleston
Ages 18 to 100 · Men · Updated Aug 13, 2026 · NCT05519449

Docetaxel to Androgen Receptor Pathway Inhibitors in Patients With Metastatic Castration Sensitive Prostate Cancer and Suboptimal PSA Response

RecruitingPhase 3
  • Medical University of South Carolina, Charleston
Ages 18 and older · Men · Updated Jul 14, 2026 · NCT06592924

International Registry for Men With Advanced Prostate Cancer (IRONMAN)

RecruitingObservational study
  • Ralph H. Johnson VA Medical Center, Charleston
Ages 21 and older · Men · Updated May 22, 2026 · NCT03151629

T-reg Function Changes: a Novel Immune Regulatory Effect Underlying Benefit of Statin Use on Lethal Prostate Cancer

RecruitingPhase 2
  • Hollings Cancer Center at Medical University of South Carolina, Charleston
Ages 18 and older · Men · Updated Mar 4, 2026 · NCT05586360

Hypofractionated Radiotherapy With a Focal Microboost for High-Risk and Locally Advanced Prostate Cancer

RecruitingPhase 2
  • Medical University of South Carolina Hollings Cancer Center, Charleston
Ages 18 and older · Men · Updated Feb 5, 2026 · NCT07325721

cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease

RecruitingObservational studyHealthy volunteers welcome
  • Medical University of South Carolina, Charleston
Ages 40 and older · All sexes · Updated Jan 20, 2026 · NCT05366881

A Phase 1/2a Study of DB-1311/BNT324 in Advanced/Metastatic Solid Tumors

RecruitingPhase 1/2
  • Research Site 123, Charleston
Ages 18 and older · All sexes · Updated Nov 21, 2025 · NCT05914116

Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer

RecruitingPhase 3
  • Medical University of South Carolina, Charleston
Ages 18 and older · Men · Updated Sep 11, 2025 · NCT03678025

About Prostate Cancer

Prostate cancer is one of the most common types of cancer among American men. The risk goes up as men age. Learn about symptoms, tests, and treatment.

More about Prostate Cancer on MedlinePlus

Prostate Cancer trials in other cities

Other studies in Charleston

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.