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Major Depressive Disorder clinical trials in Little Rock, AR

14 studies for Major Depressive Disorder are looking for participants at sites in and around Little Rock (within about 30 miles). Open a study to see who can join and how to contact the study team.

Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms

RecruitingPhase 3
  • SanRo Clinical Research Group LLC WCG Clinical Network, Bryant · 15 mi away
Ages 18 to 74 · All sexes · Updated Sep 25, 2026 · NCT06559306

Evaluation of Efficacy and Safety of Milsaperidone as Adjunctive Therapy in Patients With Major Depressive Disorder

RecruitingPhase 3
  • Vanda Investigational Site, Little Rock
Ages 18 to 65 · All sexes · Updated Sep 24, 2026 · NCT06830044

A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder (X-NOVA3)

RecruitingPhase 3
  • SanRo Clinical Research Group, Bryant · 15 mi away
Ages 18 to 74 · All sexes · Updated Sep 8, 2026 · NCT07076407

A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression

RecruitingPhase 2
  • Draig Clinical Site, Little Rock
Ages 18 to 75 · All sexes · Updated Sep 2, 2026 · NCT07610473

A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder

RecruitingPhase 3
  • SanRo Clinical Research Group LLC WCG Clinical Network, Bryant · 15 mi away
Ages 18 to 74 · All sexes · Updated Aug 28, 2026 · NCT07573176

A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression

RecruitingPhase 2
  • Draig Clinical Site, Little Rock
Ages 18 to 75 · All sexes · Updated Aug 26, 2026 · NCT07300969

NBI-1065845-MDD3025: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 3
  • Neurocrine Clinical Site, Bryant · 15 mi away
Ages 18 and older · All sexes · Updated Aug 11, 2026 · NCT06911112

A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)

RecruitingPhase 3
  • Preferred Research Partners, Inc., Little Rock
Ages 18 to 74 · All sexes · Updated Aug 10, 2026 · NCT07592689

A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder

RecruitingPhase 3
  • Woodland International Research Group, Little Rock
Ages 18 to 74 · All sexes · Updated Aug 3, 2026 · NCT06775379

Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 3
  • Neurocrine Clinical Site, Little Rock
  • Neurocrine Clinical Site, Bryant · 15 mi away
Ages 18 and older · All sexes · Updated Jul 24, 2026 · NCT06966401

A Study to Assess Change in Disease Activity and Adverse Events of Oral Icalcaprant in Adult Participants With Major Depressive Disorder

RecruitingPhase 2
  • Preferred Research Partners /ID# 279206, Little Rock
  • Woodland International Research Group /ID# 277605, Little Rock
Ages 18 to 65 · All sexes · Updated Jun 15, 2026 · NCT07276997

A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)

RecruitingPhase 2
  • Pillar Clinical Research, LLC, Little Rock
  • Preferred Research Partners, Inc., Little Rock
Ages 18 to 65 · All sexes · Updated May 11, 2026 · NCT06524830

Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 3
  • Neurocrine Clinical Site, Little Rock
Ages 18 and older · All sexes · Updated Oct 29, 2025 · NCT06786624

Major Depressive Disorder trials in other cities

Other studies in Little Rock

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.