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Multiple Myeloma clinical trials in Boston, MA

45 studies for Multiple Myeloma are looking for participants at sites in and around Boston (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

MagnetisMM-32: A Study to Learn About the Study Medicine Called Elranatamab in People With Multiple Myeloma (MM) That Has Come Back After Taking Other Treatments (Including Prior Treatment With an Anti-CD38 Antibody and Lenalidomide)

RecruitingPhase 3
  • Beth Israel Deaconess Medical Center, Boston
  • BIDMC Research Pharmacy, Boston
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT06152575

A Study to Compare Linvoseltamab and Daratumumab Treatment in High-Risk Smoldering Multiple Myeloma (HR-SMM)

RecruitingPhase 3
  • Dana Farber / Harvard Cancer Center, Boston
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07393282

A Long-term Study for Participants Previously Treated With Ciltacabtagene Autoleucel

RecruitingPhase 4
  • Dana Farber Cancer Institute, Boston
  • Beth Israel Deaconess Medical Center, Boston
  • Massachusetts General Hospital, Boston
Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT05201781

A Study Comparing JNJ-79635322 and an Anti-B-cell Maturation Antigen (BCMA)xCD3 Bispecific Antibody in Participants With Relapsed or Refractory Multiple Myeloma

RecruitingPhase 3
  • Dana Farber Cancer Institute, Boston
  • Boston University Medical Center, Boston
  • Beth Israel Deaconess Medical Center, Boston
Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT07258511

Pivotal Study to Validate a Novel System to Non-Invasively Detect Severe Neutropenia

RecruitingObservational study
  • Massachussetts General Hospital, Boston
Ages 10 and older · All sexes · Updated Nov 3, 2026 · NCT06323447

Systemic Anti-Cancer Therapy Dose Modifications for Individuals With Duffy Null Phenotype

RecruitingPhase 1
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Nov 2, 2026 · NCT07341867

ELEVATE-MM: Elotuzumab, Iberdomide and Dexamethasone Post Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma

RecruitingPhase 1
  • Brigham and Women's Hospital, Boston
  • Beth Israel Deaconess Medical Center, Boston
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Nov 2, 2026 · NCT06518551

Study to Assess Safety and Tolerability of OPN-6602 in Subjects With Relapsed and/or Refractory Multiple Myeloma

RecruitingPhase 1
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Oct 30, 2026 · NCT06433947

A Study to Evaluate the Efficacy of Cemsidomide + Dexamethasone in Participants With Relapsed/Refractory Multiple Myeloma

RecruitingPhase 2
  • Beth Israel Deaconess Medical Center, Boston
  • Dana Farber Cancer Institute, Boston
  • Massachusetts General Hospital, Boston
Ages 18 and older · All sexes · Updated Oct 30, 2026 · NCT07284758

AZD0305 as Monotherapy or in Combination With Anticancer Agents in Participants With Multiple Myeloma

RecruitingPhase 1/2
  • Research Site, Boston
Ages 18 and older · All sexes · Updated Oct 30, 2026 · NCT06106945

A Study of an MMSET Inhibitor in Patients With Relapsed and Refractory Multiple Myeloma

RecruitingPhase 1
  • Massachusetts General Hospital, Boston
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Oct 22, 2026 · NCT05651932

D2 - Isa-Iber-VD Induction, Followed by Risk & Response Adapted Consolidation & Maintenance, in Transplant-Eligible NDMM

RecruitingPhase 3
  • Beth Israel Deaconess Medical Center (BIDMC), Boston
  • Brigham and Women's Hospital, Boston
  • Dana-Farber Cancer Institute, Boston
Ages 18 to 75 · All sexes · Updated Oct 9, 2026 · NCT07624513

AZD0120 in Relapsed/Refractory Multiple Myeloma (DURGA-1)

RecruitingPhase 1/2
  • Research Site, Boston
  • Research Site, Boston
Ages 18 and older · All sexes · Updated Oct 8, 2026 · NCT05850234

Study of Arlocabtagene Autoleucel (BMS-986393) a GPRC5D-directed CAR T Cell Therapy in Adult Participants With Relapsed or Refractory Multiple Myeloma

RecruitingPhase 2
  • Massachusetts General Hospital, Boston
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Oct 6, 2026 · NCT06297226

A Study Comparing AZD0120, a Dual-targeted CAR-T Against B-cell Maturation Antigen (BCMA) and CD19, Versus Standard Regimens in Participants With Relapsed Refractory Multiple Myeloma (DURGA-4)

RecruitingPhase 3
  • Research Site, Boston
  • Research Site, Boston
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT07391657

A Study Comparing JNJ-79635322 and Teclistamab in Participants With Relapsed or Refractory Multiple Myeloma

RecruitingPhase 3
  • Tufts Medical Center, Boston
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07518186

Study of Belantamab Mafodotin With Carfilzomib, Pomalidomide, and Dexamethasone in Relapsed Multiple Myeloma

RecruitingPhase 2
  • Beth Israel Deaconess Medical Center, Boston
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT05789303

A Study of mRNA-2808 in Participants With Relapsed or Refractory Multiple Myeloma

RecruitingPhase 1/2
  • Mass General Brigham, Boston
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07116616

ELISA in Relapsed/Refractory MM

RecruitingPhase 2
  • Massachusetts General Hospital, Boston
  • Beth Israel Deaconess Medical Center, Boston
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT06832865

Elranatamab in R/R Multiple Myeloma

RecruitingPhase 2
  • Massachusetts General Hospital, Boston
  • Dana-Farber Cancer Institute, Boston
  • Beth-Israel Deaconess Medical Center, Boston
Ages 18 and older · All sexes · Updated Aug 31, 2026 · NCT06138275

Study of SIM0500 Alone in Participants With Relapsed or Refractory Multiple Myeloma

RecruitingPhase 1
  • Dana Farber Cancer institution, Boston
Ages 18 and older · All sexes · Updated Aug 28, 2026 · NCT06375044

A Study to Evaluate a Novel Gene Therapy in Patients With Relapsed and Refractory Multiple Myeloma

RecruitingPhase 1
  • Massachusetts General Hospital, Boston
Ages 18 and older · All sexes · Updated Aug 28, 2026 · NCT07075185

Testing the Use of Combination Therapy in Adult Patients With Newly Diagnosed Multiple Myeloma, the EQUATE Trial

RecruitingPhase 3
  • Tufts Medical Center, Boston
Ages 18 and older · All sexes · Updated Aug 19, 2026 · NCT04566328

A Study to Investigate the Safety and Efficacy of Belantamab for the Treatment of Multiple Myeloma When Used as Monotherapy and in Combination Treatments

RecruitingPhase 1/2
  • GSK Investigational Site, Boston
Ages 18 and older · All sexes · Updated Aug 19, 2026 · NCT05714839

A Trial to Learn if Linvoseltamab is Safe and Works in Adults With Relapsed or Refractory Systemic Light Chain Amyloidosis (AL Amyloidosis)

RecruitingPhase 1/2
  • Boston Medical Center, Boston
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT06292780

Immuno-PRISM (PRecision Intervention Smoldering Myeloma)

RecruitingPhase 2
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Jul 16, 2026 · NCT05469893

A Study to Evaluate the Safety, Effectiveness and Tolerable Dose of Arlocabtagene Autoleucel (BMS-986393) in Novel Combinations in Participants With Relapsed and/or Refractory Multiple Myeloma

RecruitingPhase 1
  • Beth Israel Deaconess Medical Center, Boston
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Jul 16, 2026 · NCT06121843

Selinexor and Backbone Treatments of Multiple Myeloma Patients

RecruitingPhase 1/2
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Jul 15, 2026 · NCT02343042

Low-Dose Radiotherapy in Treating Painful Bone Metastases in Patients With Multiple Myeloma

Recruiting
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Jun 5, 2026 · NCT03858205

DC/MM Fusion Vaccine With BCMA CAR-T in R/R MM

RecruitingPhase 1
  • Beth Israel Deaconess Medical Center, Boston
Ages 18 and older · All sexes · Updated May 8, 2026 · NCT07377435

A Phase 1 Study of Vaccination With Dendritic Cell (DC)/Multiple Myeloma (MM) Fusions in Combination With Elranatamab in Relapsed or Refractory Multiple Myeloma

RecruitingPhase 1
  • Beth Israel Deaconess Medical Center, Boston
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated May 7, 2026 · NCT06799026

Study of Oral Administration of LP-118 in Patients With Relapsed or Refractory CLL, SLL, MDS, MDS/MPN, AML, CMML-2, MPN-BP, ALL, MF, NHL, RT, MM or T-PLL.

RecruitingPhase 1
  • Dana Farber Cancer Institute, Boston
Ages 13 and older · All sexes · Updated May 5, 2026 · NCT04771572

Defining the Role of Palliative carE for Patients With Hematologic Malignancies Undergoing Adoptive CEllular Therapy

Recruiting
  • Massachusetts General Hospital Cancer Center, Boston
Ages 18 and older · All sexes · Updated Apr 21, 2026 · NCT05646576

Mezigdomide and Talquetamab in Relapsed and Refractory Multiple Myeloma

RecruitingPhase 1
  • Massachusetts General Hospital, Boston
  • Beth Israel Deaconess Medical Center, Boston
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Apr 13, 2026 · NCT07032714

Study of ISB 2001 in Relapsed/Refractory Multiple Myeloma (TRIgnite-1)

RecruitingPhase 1
  • Beth Israel Deaconess Medical Center, Boston
Ages 18 and older · All sexes · Updated Apr 1, 2026 · NCT05862012

A Phase 1/2 Study of Enzomenib (DSP-5336) in Patients With Acute Leukemia (Horizen-1)

RecruitingPhase 1/2
  • Massachusetts General Hospital, Boston
Ages 12 and older · All sexes · Updated Mar 24, 2026 · NCT04988555

A Study to Assess BMS-986453 in Participants With Relapsed and/or Refractory Multiple Myeloma

RecruitingPhase 1
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Mar 18, 2026 · NCT06153251

Prehabilitation Exercise Training in Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation

Recruiting
  • Dana Farber Cancer Institute, Boston
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Jan 22, 2026 · NCT05706766

Isatuximab, Bela Maf, Pom, and Dex in Relapsed/Refractory Multiple Myeloma

RecruitingPhase 2
  • Massachusetts General Hospital, Boston
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Jan 14, 2026 · NCT05922501

Collection of Samples and Clinical Data From Patients With Amyloid Diseases

RecruitingObservational study
  • Boston University Cancer Research Center, Boston
Ages 18 and older · All sexes · Updated Dec 1, 2025 · NCT00898235

A Study to Evaluate Safety, Drug Levels and Effectiveness of CC-92480 (BMS-986348) in Combination With Other Treatments in Participants With Relapsed or Refractory Multiple Myeloma

RecruitingPhase 1/2
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Sep 5, 2025 · NCT05372354

About Multiple Myeloma

Multiple myeloma is a cancer that begins in plasma cells, a type of white blood cell. Discover symptoms, diagnostic tests, and treatments for myeloma.

More about Multiple Myeloma on MedlinePlus

Multiple Myeloma trials in other cities

Other studies in Boston

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.