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Opioid Overdose clinical trials in Philadelphia, PA

15 studies for Opioid Overdose are looking for participants at sites in and around Philadelphia (within about 30 miles). Open a study to see who can join and how to contact the study team.

A Study of Brenipatide in Participants With Opioid Use Disorder

RecruitingPhase 2
  • Adams Clinical Philadelphia, Philadelphia
  • Penn Medicine: University of Pennsylvania Health System, Philadelphia
Ages 18 to 75 · All sexes · Updated Sep 22, 2026 · NCT07420283

A Study Comparing Oral Buprenorphine and Injectable Buprenorphine for the Treatment of Opioid Use Disorder

RecruitingPhase 4
  • Philadelphia MultiService Center, Philadelphia, PA, Philadelphia
  • Wilmington VA Medical Center, Wilmington, DE, Wilmington · 25 mi away
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT04375033

Adapting the Penny Chatbot for Perinatal OUD Patients: COPILOT

Recruiting
  • Hospital of the University of Pennsylvania (HUP), Philadelphia
  • University of Pennsylvania, Philadelphia
All ages · Women · Updated Jul 28, 2026 · NCT06969261

UnityPhilly Response App for Overdose Reversal

RecruitingHealthy volunteers welcome
  • Drexel University, Philadelphia
Ages 18 and older · All sexes · Updated Jul 20, 2026 · NCT06466005

Rapid Outpatient Low-dose Initiation of Buprenorphine for OUD With Fentanyl Use

RecruitingPhase 2
  • University of Pennsylvania Center for Studies of Addiction, Philadelphia
Ages 18 and older · All sexes · Updated Jul 10, 2026 · NCT06379984

Autobiographical Memory in Opioid Use Disorder

RecruitingHealthy volunteers welcome
  • University of Pennsylvania, Philadelphia
Ages 18 to 60 · All sexes · Updated Jul 10, 2026 · NCT06643988

Psilocybin on Brain Mechanisms of Motivation in OUD

RecruitingPhase 2
  • University of Pennsylvania, Philadelphia
Ages 18 to 60 · All sexes · Updated Jul 9, 2026 · NCT06810310

An Intervention Mapping Approach to Closing the Gap in Maternal OUD and Infant NAS Care (SUPPORT)

RecruitingHealthy volunteers welcome
  • Hospital of the University of Pennsylvania, Philadelphia
  • Penn Center for Women's Behavioral Wellness, Philadelphia
  • Pennsylvania Hospital, Philadelphia
Ages 18 and older · All sexes · Updated Jul 6, 2026 · NCT06576323

Adolescent Outcomes of Post-operative Opioid EXposure

RecruitingObservational study
  • Children's Hospital of Philadelphia, Philadelphia
Ages 12 to 17 · All sexes · Updated Mar 18, 2026 · NCT06350409

Integrating Brain, Neurocognitive, and Computational Tools in OUD

RecruitingObservational study
  • University of Pennsylvania, Philadelphia
Ages 18 to 60 · All sexes · Updated Dec 4, 2025 · NCT06136247

NavSTAR Implementation Effectiveness Trial Across a Health System

Recruiting
  • Jefferson Health, Philadelphia
Ages 18 and older · All sexes · Updated Dec 3, 2025 · NCT07262190

Wellcome Leap Psilocybin for OUD

RecruitingPhase 2
  • University of Pennsylvania, Philadelphia
Ages 18 to 60 · All sexes · Updated Oct 29, 2025 · NCT06786325

MethaLoad Dose-Finding Study

RecruitingPhase 1
  • Penn Center for Studies of Addiction (CSA), Philadelphia
Ages 18 and older · All sexes · Updated Oct 14, 2025 · NCT06877858

Disclosure Intervention for People in Treatment for Opioid Use Disorder

Recruiting
  • Brandywine Counseling & Community Services, Wilmington · 25 mi away
Ages 18 and older · All sexes · Updated Jul 18, 2025 · NCT06458985

Opioid Treatment and Peer Recovery Support

Recruiting
  • Temple University, Philadelphia
Ages 18 and older · All sexes · Updated May 13, 2025 · NCT04978168

About Opioid Overdose

Opioid overdose leads to slowing or stopping of breathing and sometimes death. You can take steps to help prevent an overdose, and respond to one with naloxone.

More about Opioid Overdose on MedlinePlus

Opioid Overdose trials in other cities

Other studies in Philadelphia

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.